Skip to main content
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Accessibility Statement
    • Rights and Permissions
    • Site Map
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian
  • Log in
  • My Cart

Main menu

  • Home
  • Articles
    • Current
    • Special Feature Articles - Most Recent
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • List of Issues
  • Front Matter
  • News
    • For the Press
    • This Week In PNAS
    • PNAS in the News
  • Podcasts
  • Authors
    • Information for Authors
    • Editorial and Journal Policies
    • Submission Procedures
    • Fees and Licenses
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Accessibility Statement
    • Rights and Permissions
    • Site Map
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Home
Home

Advanced Search

  • Home
  • Articles
    • Current
    • Special Feature Articles - Most Recent
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • List of Issues
  • Front Matter
  • News
    • For the Press
    • This Week In PNAS
    • PNAS in the News
  • Podcasts
  • Authors
    • Information for Authors
    • Editorial and Journal Policies
    • Submission Procedures
    • Fees and Licenses

New Research In

Physical Sciences

Featured Portals

  • Physics
  • Chemistry
  • Sustainability Science

Articles by Topic

  • Applied Mathematics
  • Applied Physical Sciences
  • Astronomy
  • Computer Sciences
  • Earth, Atmospheric, and Planetary Sciences
  • Engineering
  • Environmental Sciences
  • Mathematics
  • Statistics

Social Sciences

Featured Portals

  • Anthropology
  • Sustainability Science

Articles by Topic

  • Economic Sciences
  • Environmental Sciences
  • Political Sciences
  • Psychological and Cognitive Sciences
  • Social Sciences

Biological Sciences

Featured Portals

  • Sustainability Science

Articles by Topic

  • Agricultural Sciences
  • Anthropology
  • Applied Biological Sciences
  • Biochemistry
  • Biophysics and Computational Biology
  • Cell Biology
  • Developmental Biology
  • Ecology
  • Environmental Sciences
  • Evolution
  • Genetics
  • Immunology and Inflammation
  • Medical Sciences
  • Microbiology
  • Neuroscience
  • Pharmacology
  • Physiology
  • Plant Biology
  • Population Biology
  • Psychological and Cognitive Sciences
  • Sustainability Science
  • Systems Biology
Research Article

Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells

G. M. Pitari, M. D. Di Guglielmo, J. Park, S. Schulz, and S. A. Waldman
PNAS July 3, 2001 98 (14) 7846-7851; https://doi.org/10.1073/pnas.141124698
G. M. Pitari
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. D. Di Guglielmo
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Park
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Schulz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. A. Waldman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  1. Edited by Robert F. Furchgott, State University of New York Downstate Medical Center, Brooklyn, NY, and approved May 8, 2001 (received for review March 13, 2001)

  • Article
  • Figures & SI
  • Info & Metrics
  • PDF
Loading

Online Impact

 

Article Information

vol. 98 no. 14 7846-7851
DOI: 
https://doi.org/10.1073/pnas.141124698
PubMed: 
11438734

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Received March 13, 2001
  • Published July 3, 2001.

Copyright & Usage: 
Copyright © 2001, The National Academy of Sciences

Author Information

  1. G. M. Pitari*†‡,
  2. M. D. Di Guglielmo*,
  3. J. Park*,
  4. S. Schulz*, and
  5. S. A. Waldman*
  1. *Division of Clinical Pharmacology, Departments of Medicine, and Biochemistry and Molecular Pharmacology, Thomas Jefferson University, 132 South 10th Street, 1170 Main, Philadelphia, PA 19107; and †Department of Pharmacology, University of Catania Medical School, 96125 Catania, Italy
  1. Edited by Robert F. Furchgott, State University of New York Downstate Medical Center, Brooklyn, NY, and approved May 8, 2001 (received for review March 13, 2001)

Footnotes

    • ↵‡ To whom reprint requests should be addressed at: Division of Clinical Pharmacology, Thomas Jefferson University, 1100 Walnut Street, 811 Medical Office Building, Philadelphia, PA 19107. E-mail: gmpitari{at}yahoo.com.

    • This paper was submitted directly (Track II) to the PNAS office.

    Cited By...

    • 120 Citations
    • 111 Citations
    • Google Scholar

    This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

    • Guanylyl cyclase structure, function and regulation
      Lincoln R. Potter
      Cellular Signalling 2011 23 12
    • Clinical and Molecular Genetics of the Phosphodiesterases (PDEs)
      Monalisa F. Azevedo, Fabio R. Faucz, Eirini Bimpaki, Anelia Horvath, Isaac Levy, Rodrigo B. de Alexandre, Faiyaz Ahmad, Vincent Manganiello, Constantine A. Stratakis
      Endocrine Reviews 2014 35 2
    • Bacterial enterotoxins are associated with resistance to colon cancer
      G. M. Pitari, L. V. Zingman, D. M. Hodgson, A. E. Alekseev, S. Kazerounian, M. Bienengraeber, G. Hajnoczky, A. Terzic, S. A. Waldman
      Proceedings of the National Academy of Sciences 2003 100 5
    • The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment
      Alexandra Fajardo, Gary Piazza, Heather Tinsley
      Cancers 2014 6 1
    • Guanylyl Cyclase C Suppresses Intestinal Tumorigenesis by Restricting Proliferation and Maintaining Genomic Integrity
      Peng Li, Stephanie Schulz, Alessandro Bombonati, Juan P. Palazzo, Terry M. Hyslop, Yihuan Xu, Amy A. Baran, Linda D. Siracusa, Giovanni M. Pitari, Scott A. Waldman
      Gastroenterology 2007 133 2
    • Targeting cancer with phosphodiesterase inhibitors
      Rajkumar Savai, Soni Savai Pullamsetti, Gamal-Andre Banat, Norbert Weissmann, Hossein Ardeschir Ghofrani, Friedrich Grimminger, Ralph Theo Schermuly
      Expert Opinion on Investigational Drugs 2010 19 1
    • Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract
      Ruth Birbe, Juan P. Palazzo, Rhonda Walters, David Weinberg, Stephanie Schulz, Scott A. Waldman
      Human Pathology 2005 36 2
    • Homeostatic Control of the Crypt-Villus Axis by the Bacterial Enterotoxin Receptor Guanylyl Cyclase C Restricts the Proliferating Compartment in Intestine
      Peng Li, Jieru E. Lin, Inna Chervoneva, Stephanie Schulz, Scott A. Waldman, Giovanni M. Pitari
      The American Journal of Pathology 2007 171 6
    • Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells
      Bing Zhu, Lakshmi Vemavarapu, W. Joseph Thompson, Samuel J. Strada
      Journal of Cellular Biochemistry 2005 94 2
    • Targeted Inactivation of the Mouse Guanylin Gene Results in Altered Dynamics of Colonic Epithelial Proliferation
      Kris A. Steinbrecher, Steve A. Wowk, Jeffrey A. Rudolph, David P. Witte, Mitchell B. Cohen
      The American Journal of Pathology 2002 161 6
    • The Hormone Receptor GUCY2C Suppresses Intestinal Tumor Formation by Inhibiting AKT Signaling
      Jieru Egeria Lin, Peng Li, Adam Eugene Snook, Stephanie Schulz, Abhijit Dasgupta, Terry Marie Hyslop, Ahmara Vivian Gibbons, Glen Marszlowicz, Giovanni Mario Pitari, Scott Arthur Waldman
      Gastroenterology 2010 138 1
    • Bile Acids Induce Ectopic Expression of Intestinal Guanylyl Cyclase C Through Nuclear Factor-κB and Cdx2 in Human Esophageal Cells
      Philip R. Debruyne, Matthew Witek, Li Gong, Ruth Birbe, Inna Chervoneva, Tianru Jin, Claire Domon–Cell, Juan P. Palazzo, Jean–Noel Freund, Peng Li, Giovanni M. Pitari, Stephanie Schulz, Scott A. Waldman
      Gastroenterology 2006 130 4
    • Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets
      F Ahmad, T Murata, K Shimizu, E Degerman, D Maurice, V Manganiello
      Oral Diseases 2015 21 1
    • A Validated Quantitative Assay to Detect Occult Micrometastases by Reverse Transcriptase-Polymerase Chain Reaction of Guanylyl Cyclase C in Patients with Colorectal Cancer
      Stephanie Schulz, Terry Hyslop, Janis Haaf, Christine Bonaccorso, Karl Nielsen, Matthew E. Witek, Ruth Birbe, Juan Palazzo, David Weinberg, Scott A. Waldman
      Clinical Cancer Research 2006 12 15
    • Benzethonium Chloride: A Novel Anticancer Agent Identified by Using a Cell-Based Small-Molecule Screen
      Kenneth W. Yip, Xinliang Mao, P.Y. Billie Au, David W. Hedley, Sue Chow, Shadi Dalili, Joseph D. Mocanu, Carlo Bastianutto, Aaron Schimmer, Fei-Fei Liu
      Clinical Cancer Research 2006 12 18
    • cGMP: Generators, Effectors and Therapeutic Implications
      Michaela Kuhn
      2009 191
    • The Putative Tumor Suppressor Cdx2 Is Overexpressed by Human Colorectal Adenocarcinomas
      Matthew E. Witek, Karl Nielsen, Rhonda Walters, Terry Hyslop, Juan Palazzo, Stephanie Schulz, Scott A. Waldman
      Clinical Cancer Research 2005 11 24
    • Cellular Effects of Guanylin and Uroguanylin
      Aleksandra Sinđić, Eberhard Schlatter
      Journal of the American Society of Nephrology 2006 17 3
    • Receptor guanylyl cyclase C (GC-C): regulation and signal transduction
      Nirmalya Basu, Najla Arshad, Sandhya S. Visweswariah
      Molecular and Cellular Biochemistry 2010 334 1-2
    • PKG inhibits TCF signaling in colon cancer cells by blocking β-catenin expression and activating FOXO4
      I-K Kwon, R Wang, M Thangaraju, H Shuang, K Liu, R Dashwood, N Dulin, V Ganapathy, D D Browning
      Oncogene 2010 29 23
    • Guanylyl cyclase C: a molecular marker for staging and postoperative surveillance of patients with colorectal cancer
      Glen S Frick, Giovanni M Pitari, David S Weinberg, Terry Hyslop, Stephanie Schulz, Scott A Waldman
      Expert Review of Molecular Diagnostics 2005 5 5
    • The multiple and enigmatic roles of guanylyl cyclase C in intestinal homeostasis
      Najla Arshad, Sandhya S. Visweswariah
      FEBS Letters 2012 586 18
    • The Paracrine Hormone Hypothesis of Colorectal Cancer
      G M Pitari, P Li, J E Lin, D Zuzga, A V Gibbons, A E Snook, S Schulz, S A Waldman
      Clinical Pharmacology & Therapeutics 2007 82 4
    • Murine Guanylate Cyclase C Regulates Colonic Injury and Inflammation
      Kris A. Steinbrecher, Eleana Harmel-Laws, Monica P. Garin-Laflam, Elizabeth A. Mann, Lucas D. Bezerra, Simon P. Hogan, Mitchell B. Cohen
      The Journal of Immunology 2011 186 12
    • Natriuretic Hormones in Brain Function
      Anastasia Hodes, David Lichtstein
      Frontiers in Endocrinology 2014 5
    • Intestinal Cell Proliferation and Senescence Are Regulated by Receptor Guanylyl Cyclase C and p21
      Nirmalya Basu, Sayanti Saha, Imran Khan, Subbaraya G. Ramachandra, Sandhya S. Visweswariah
      Journal of Biological Chemistry 2014 289 1
    • Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity
      N Li, K Lee, Y Xi, B Zhu, B D Gary, V Ramírez-Alcántara, E Gurpinar, J C Canzoneri, A Fajardo, S Sigler, J T Piazza, X Chen, J Andrews, M Thomas, W Lu, Y Li, D J Laan, M P Moyer, S Russo, B T Eberhardt, L Yet, A B Keeton, W E Grizzle, G A Piazza
      Oncogene 2015 34 12
    • Cure and Curse: E. coli Heat-Stable Enterotoxin and Its Receptor Guanylyl Cyclase C
      Philipp R. Weiglmeier, Paul Rösch, Hanna Berkner
      Toxins 2010 2 9
    • The Paracrine Hormone for the GUCY2C Tumor Suppressor, Guanylin, Is Universally Lost in Colorectal Cancer
      Chantell Wilson, Jieru E. Lin, Peng Li, Adam E. Snook, Jianping Gong, Takahiro Sato, Chengbao Liu, Melanie A. Girondo, Hallgeir Rui, Terry Hyslop, Scott A. Waldman
      Cancer Epidemiology Biomarkers & Prevention 2014 23 11
    • cGMP-dependent protein kinases as potential targets for colon cancer prevention and treatment
      Darren D Browning, In-Kiu Kwon, Rui Wang
      Future Medicinal Chemistry 2010 2 1
    • Activation of guanylate cyclase C signaling pathway protects intestinal epithelial cells from acute radiation-induced apoptosis
      M. P. Garin-Laflam, K. A. Steinbrecher, J. A. Rudolph, J. Mao, M. B. Cohen
      American Journal of Physiology-Gastrointestinal and Liver Physiology 2009 296 4
    • Cross Talk between Receptor Guanylyl Cyclase C and c-src Tyrosine Kinase Regulates Colon Cancer Cell Cytostasis
      Nirmalya Basu, Rashna Bhandari, Vivek T. Natarajan, Sandhya S. Visweswariah
      Molecular and Cellular Biology 2009 29 19
    • Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer
      David S. Zuzga, Joshua Pelta-Heller, Peng Li, Alessandro Bombonati, Scott A. Waldman, Giovanni M. Pitari
      International Journal of Cancer 2012 130 11
    • Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice
      Bianca N. Islam, Sarah K. Sharman, Yali Hou, Allison E. Bridges, Nagendra Singh, Sangmi Kim, Ravindra Kolhe, Jimena Trillo-Tinoco, Paulo C. Rodriguez, Franklin G. Berger, Subbaramiah Sridhar, Darren D. Browning
      Cancer Prevention Research 2017 10 7
    • Guanylyl Cyclase C Prevents Colon Cancer Metastasis by Regulating Tumor Epithelial Cell Matrix Metalloproteinase-9
      Wilhelm J. Lubbe, David S. Zuzga, Zengyi Zhou, Weili Fu, Joshua Pelta-Heller, Ruth J. Muschel, Scott A. Waldman, Giovanni M. Pitari
      Cancer Research 2009 69 8
    • Type 2 cGMP-dependent protein kinase regulates proliferation and differentiation in the colonic mucosa
      Rui Wang, In-Kiu Kwon, Muthusamy Thangaraju, Nagendra Singh, Kebin Liu, Philippe Jay, Franz Hofmann, Vadivel Ganapathy, Darren D. Browning
      American Journal of Physiology-Gastrointestinal and Liver Physiology 2012 303 2
    • Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders
      Scott A Waldman, Michael Camilleri
      Gut 2018 67 8
    • Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics
      Jieru E. Lin, Michael Valentino, Glen Marszalowicz, Michael S. Magee, Peng Li, Adam E. Snook, Brian A. Stoecker, Chang Chang, Scott A. Waldman
      Toxins 2010 2 8
    • Interruption of Homologous Desensitization in Cyclic Guanosine 3′,5′-Monophosphate Signaling Restores Colon Cancer Cytostasis by Bacterial Enterotoxins
      Giovanni M. Pitari, Ronnie I. Baksh, David M. Harris, Peng Li, Shiva Kazerounian, Scott A. Waldman
      Cancer Research 2005 65 23
    • Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis
      In-Kiu Kwon, Patricia V. Schoenlein, Jennifer Delk, Kebin Liu, Muthusmy Thangaraju, Nickolai O. Dulin, Vadivel Ganapathy, Franklin G. Berger, Darren D. Browning
      Cancer 2008 112 7
    • Proliferative Signaling by Store-Operated Calcium Channels Opposes Colon Cancer Cell Cytostasis Induced by Bacterial Enterotoxins
      Shiva Kazerounian, Giovanni M. Pitari, Fawad J. Shah, Glen S. Frick, Muniswamy Madesh, Inez Ruiz-Stewart, Stephanie Schulz, Gyorgy Hajnóczky, Scott A. Waldman
      Journal of Pharmacology and Experimental Therapeutics 2005 314 3
    • Guanylin and Functional Coupling Proteins in the Human Salivary Glands and Gland Tumors
      Hasan Kulaksiz, Elisabeth Rehberg, Wolfgang Stremmel, Yalcin Cetin
      The American Journal of Pathology 2002 161 2
    • Involvement of Quorum Sensing and Heat-Stable Enterotoxin a in Cell Damage Caused by a Porcine EnterotoxigenicEscherichia coliStrain
      Jing Zhu, Xianhua Yin, Hai Yu, Liping Zhao, Parviz Sabour, Joshua Gong, S. M. Payne
      Infection and Immunity 2011 79 4
    • Effect of Guanylate Cyclase-C Activity on Energy and Glucose Homeostasis
      Denovan P. Begg, Kris A. Steinbrecher, Joram D. Mul, Adam P. Chambers, Rohit Kohli, April Haller, Mitchell B. Cohen, Stephen C. Woods, Randy J. Seeley
      Diabetes 2014 63 11
    • Guanylate cyclase C limits systemic dissemination of a murine enteric pathogen
      Elizabeth A Mann, Eleana Harmel-Laws, Mitchell B Cohen, Kris A Steinbrecher
      BMC Gastroenterology 2013 13 1
    • Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target
      Jieru E Lin, Peng Li, Giovanni M Pitari, Stephanie Schulz, Scott A Waldman
      Future Oncology 2009 5 4
    • Linaclotide - a secretagogue and antihyperalgesic agent - what next?
      a. e. bharucha, d. r. linden
      Neurogastroenterology & Motility 2010 22 3
    • Enterotoxin preconditioning restores calcium-sensing receptor-mediated cytostasis in colon cancer cells
      Giovanni M. Pitari, Jieru E. Lin, Fawad J. Shah, Wilhelm J. Lubbe, David S. Zuzga, Peng Li, Stephanie Schulz, Scott A. Waldman
      Carcinogenesis 2008 29 8
    • Enterotoxigenic Escherichia coli Modulates Host Intestinal Cell Membrane Asymmetry and Metabolic Activity
      Amber M. Johnson, Radhey S. Kaushik, Nicholas J. Rotella, Philip R. Hardwidge
      Infection and Immunity 2009 77 1
    • The cGMP-binding, cGMP-specific phosphodiesterase (PDE5): intestinal cell expression, regulation and role in fluid secretion
      Shailaja Sopory, Tanvir Kaur, Sandhya S. Visweswariah
      Cellular Signalling 2004 16 6
    • Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention
      David S. Weinberg, Jieru E. Lin, Nathan R. Foster, Gary Della'Zanna, Asad Umar, Drew Seisler, Walter K. Kraft, David M. Kastenberg, Leo C. Katz, Paul J. Limburg, Scott A. Waldman
      Cancer Prevention Research 2017 10 6
    • Computational analyses and prediction of guanylin deleterious SNPs
      William F. Porto, Octávio L. Franco, Sérgio A. Alencar
      Peptides 2015 69
    • Diarrhea or colorectal cancer: Can bacterial toxins serve as a treatment for colon cancer?
      S. L. Carrithers
      Proceedings of the National Academy of Sciences 2003 100 6
    • Protein kinase G as a therapeutic target for the treatment of metastatic colorectal cancer
      Darren D Browning
      Expert Opinion on Therapeutic Targets 2008 12 3
    • Transmembrane guanylate cyclase in intestinal pathophysiology
      Kris A Steinbrecher, Mitchell B Cohen
      Current Opinion in Gastroenterology 2011 27 2
    • Colorectal Cancer Is a Paracrine Deficiency Syndrome Amenable to Oral Hormone Replacement Therapy
      Peng Li, Jieru E. Lin, Adam E. Snook, Ahmara V. Gibbons, David S. Zuzga, Stephanie Schulz, Giovanni M. Pitari, Scott A. Waldman
      Clinical and Translational Science 2008 1 2
    • Lack of guanylyl cyclase C, the receptor forEscherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model
      Elizabeth A. Mann, Kris A. Steinbrecher, Carmen Stroup, David P. Witte, Mitchell B. Cohen, Ralph A. Giannella
      International Journal of Cancer 2005 116 4
    • Site-specific N-Linked Glycosylation of Receptor Guanylyl Cyclase C Regulates Ligand Binding, Ligand-mediated Activation and Interaction with Vesicular Integral Membrane Protein 36, VIP36
      Najla Arshad, Suhas Ballal, Sandhya S. Visweswariah
      Journal of Biological Chemistry 2013 288 6
    • Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C
      Yashoda Ghanekar, Akhila Chandrashaker, Sandhya S. Visweswariah
      European Journal of Biochemistry 2003 270 18
    • Current Understanding of Guanylin Peptides Actions
      Aleksandra Sindic
      ISRN Nephrology 2013 2013
    • Intestinal GUCY2C Prevents TGF-β Secretion Coordinating Desmoplasia and Hyperproliferation in Colorectal Cancer
      Ahmara V. Gibbons, Jieru E. Lin, Gilbert W. Kim, Glen P. Marszalowicz, Peng Li, Brian A. Stoecker, Erik S. Blomain, Satish Rattan, Adam E. Snook, Stephanie Schulz, Scott A. Waldman
      Cancer Research 2013 73 22
    • Molecular staging individualizing cancer management
      Alex Mejia, Stephanie Schulz, Terry Hyslop, David S. Weinberg, Scott A. Waldman
      Journal of Surgical Oncology 2012 105 5
    • The Guanylate Cyclase C—cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia
      Jeffrey A. Rappaport, Scott A. Waldman
      Frontiers in Oncology 2018 8
    • Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer
      Allison A. Aka, Jeff A. Rappaport, Amanda M. Pattison, Takami Sato, Adam E. Snook, Scott A. Waldman
      Expert Review of Clinical Pharmacology 2017 10 5
    • GUCY2C: at the intersection of obesity and cancer
      Gilbert W. Kim, Jieru E. Lin, Scott A. Waldman
      Trends in Endocrinology & Metabolism 2013 24 4
    • Serine phosphorylation of vasodilator-stimulated phosphoprotein (VASP) regulates colon cancer cell survival and apoptosis
      Mehboob Ali, Lynette K. Rogers, Giovanni M. Pitari
      Life Sciences 2015 123
    • The Permissive Effect of Zinc Deficiency on Uroguanylin and Inducible Nitric Oxide Synthase Gene Upregulation in Rat Intestine Induced by Interleukin 1α Is Rapidly Reversed by Zinc Repletion
      Li Cui, Raymond K. Blanchard, Robert J. Cousins
      The Journal of Nutrition 2003 133 1
    • Cyclic-GMP–Elevating Agents Suppress Polyposis in ApcMin Mice by Targeting the Preneoplastic Epithelium
      Sarah K. Sharman, Bianca N. Islam, Yali Hou, Nagendra Singh, Franklin G. Berger, Subbaramiah Sridhar, Wonsuk Yoo, Darren D. Browning
      Cancer Prevention Research 2018 11 2
    • Uroguanylin inhibits proliferation of pancreatic cancer cells
      Oliver Kloeters, Helmut Friess, Nathalia Giese, Markus W. Buechler, Yalcin Cetin, Hasan Kulaksiz
      Scandinavian Journal of Gastroenterology 2008 43 4
    • Emerging treatments in Neurogastroenterology: Perspectives of guanylyl cyclase C agonists use in functional gastrointestinal disorders and inflammatory bowel diseases
      A. Jarmuż, M. Zielińska, M. Storr, J. Fichna
      Neurogastroenterology & Motility 2015 27 8
    • Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells
      Giovanni Mario Pitari, Tong Li, Ronnie I. Baksh, Scott A. Waldman
      Molecular Cancer Therapeutics 2006 5 5
    • Guanylin peptides and colorectal cancer (CRC)
      Marcello Camici
      Biomedicine & Pharmacotherapy 2008 62 2
    • Hepatocyte Growth Factor from a Clinical Perspective: A Pancreatic Cancer Challenge
      Wasia Rizwani, Amanda Allen, Jose Trevino
      Cancers 2015 7 3
    • Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCCmice
      Wen-Chi L Chang, Shet Masih, Anusha Thadi, Viren Patwa, Apoorva Joshi, Harry S Cooper, Vaseem A Palejwala, Margie L Clapper, Kunwar Shailubhai
      World Journal of Gastrointestinal Pharmacology and Therapeutics 2017 8 1
    • Mucosally restricted antigens as novel immunological targets for antitumor therapy
      Adam E Snook, Benjamin J Stafford, Laurence C Eisenlohr, Jay L Rothstein, Scott A Waldman
      Biomarkers in Medicine 2007 1 1
    • Enterotoxin/Guanylin Receptor Type Guanylyl Cyclases in Non-Mammalian Vertebrates
      Mina Nakauchi, Norio Suzuki
      Zoological Science 2005 22 5
    • GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patients
      Alex Mejia, Stephanie Schulz, Terry Hyslop, David S Weinberg, Scott A Waldman
      Expert Review of Molecular Diagnostics 2009 9 8
    • Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis
      Erik S Blomain, Jieru E Lin, Crystal L Kraft, Urszula T Trela, Justin M Rock, Amanda S Aing, Adam E Snook, Scott A Waldman
      Expert Review of Clinical Pharmacology 2013 6 5
    • GUCY2C ligand replacement to prevent colorectal cancer
      Erik S. Blomain, Amanda M. Pattison, Scott A. Waldman
      Cancer Biology & Therapy 2016 17 7
    • Lack of Guanylate Cyclase C results in increased mortality in mice following liver injury
      Elizabeth A Mann, Kumar Shanmukhappa, Mitchell B Cohen
      BMC Gastroenterology 2010 10 1
    • From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones
      A.A.M. Lima, M.C. Fonteles
      Brazilian Journal of Medical and Biological Research 2014 47 3
    • Phosphodiesterase Type 5 as a Candidate Therapeutic Target in Cancers
      Ines Barone, Cinzia Giordano, Daniela Bonofiglio, Stefania Catalano, Sebastiano Andò
      Current Pathobiology Reports 2015 3 3
    • Targeting the paracrine hormone-dependent guanylate cyclase/cGMP/phosphodiesterases signaling pathway for colorectal cancer prevention
      N.S. Yarla, H. Gali, G. Pathuri, S. Smriti, M. Farooqui, J. Panneerselvam, G. Kumar, V. Madka, C.V. Rao
      Seminars in Cancer Biology 2019 56
    • Increased efficacy of inactivated vaccine candidates prepared with Salmonella enterica serovar Typhimurium strains of predominant genotypes in ducks
      S.Y. Youn, Y.K. Kwon, C.S. Song, H.J. Lee, O.M. Jeong, B.K. Choi, S.C. Jung, M.S. Kang
      Poultry Science 2016 95 8
    • Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases
      Heather N. Tinsley, Gary A. Piazza
      Current Colorectal Cancer Reports 2012 8 4
    • Phosphodiesterase 5 (PDE5) Is Highly Expressed in Cancer-Associated Fibroblasts and Enhances Breast Tumor Progression
      Catalano, Panza, Augimeri, Giordano, Malivindi, Gelsomino, Marsico, Giordano, Győrffy, Bonofiglio, Andò, Barone
      Cancers 2019 11 11
    • ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice
      Peng Li, Jieru Lin, Adam Snook, Scott Waldman
      Toxins 2017 9 9
    • GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress
      Crystal L. Kraft, Jeffrey A. Rappaport, Adam E. Snook, Amanda M. Pattison, John P. Lynch, Scott A. Waldman
      Oncotarget 2017 8 61
    • PDE2 Is a Novel Target for Attenuating Tumor Formation in a Mouse Model of UVB-Induced Skin Carcinogenesis
      Jamie J. Bernard, You-Rong Lou, Qing-Yun Peng, Tao Li, Yao-Ping Lu, Andrzej T. Slominski
      PLoS ONE 2014 9 10
    • Update on COX-2 inhibitor patents with a focus on optimised formulation and therapeutic scope of drug combinations making use of COX-2 inhibitors
      Ulrike Puhlmann, Dirk Schäfer, Christina Ziemann
      Expert Opinion on Therapeutic Patents 2006 16 4
    • Alex Mejia, Stephanie Schulz, Terry Hyslop, David S. Weinberg, Scott A. Waldman
      2010 52
    • A two step method to identify clinical outcome relevant genes with microarray data
      Bin Han, Lihua Li, Yan Chen, Lei Zhu, Qi Dai
      Journal of Biomedical Informatics 2011 44 2
    • APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis
      Erik S. Blomain, Jeffrey A. Rappaport, Amanda M. Pattison, Babar Bashir, Ellen Caparosa, Jonathan Stem, Adam E. Snook, Scott A. Waldman
      Cancer Biology & Therapy 2020 21 5
    • Expression of guanylyl cyclase C in tissue samples and the circulation of rectal cancer patients
      Yong Liu, Guoping Cheng, Jun Qian, HaiXing Ju, YuPing Zhu, Meucci Stefano, Ulrich Keilholz, DeChuan Li
      Oncotarget 2017 8 24
    • GUCY2C molecular staging personalizes colorectal cancer patient management
      Jian P Gong, Stephanie Schulz, Terry Hyslop, Scott A Waldman
      Biomarkers in Medicine 2012 6 3
    • Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms
      Vincenzo Ciocca, Alessandro Bombonati, Juan P Palazzo, Stephanie Schulz, Scott A Waldman
      Histopathology 2009 55 2
    • The prognostic and therapeutic role of hormones in colorectal cancer: a review
      Stella Nikolaou, Shengyang Qiu, Francesca Fiorentino, Shahnawaz Rasheed, Paris Tekkis, Christos Kontovounisios
      Molecular Biology Reports 2019 46 1
    • Satish R Tiyyagura, Shiva Kazerounian, Stephanie Schulz, Scott A Waldman, Giovanni M Pitari
      2004 69
    • Biophysiology of natriuretic peptides in the evolutionary varieties of vertebrate osmoregulatory systems from shark rectal to mammalian salivary glands
      Masahiko Mori, Tadakatsu Kasai, Yoshiaki Takai, Michio Shikimori
      Oral Medicine & Pathology 2010 15 1
    • Guanylyl cyclase receptor C
      Sandhya Visweswariah
      AfCS-Nature Molecule Pages 2006
    • Handbook of Cell Signaling
      Lincoln R. Potter
      2010
    • Les cyclostatines bactériennes ou comment les bactéries manipulent le cycle cellulaire eucaryote
      Jean De Rycke, Bernard Ducommun
      médecine/sciences 2003 19 11
    • Radiolabeled Escherichia coli heat-stable enterotoxin analogs for in vivo imaging of colorectal cancer
      M.F. Giblin, G.L. Sieckman, N.K. Owen, T.J. Hoffman, L.R. Forte, W.A. Volkert
      Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 2005 241 1-4
    • An update on guanylyl cyclase C in the diagnosis, chemoprevention, and treatment of colorectal cancer
      Jeffrey A. Rappaport, Scott A. Waldman
      Expert Review of Clinical Pharmacology 2020 13 10
    • Bacterial Protein Toxins
      Bernard Ducommun, Jean De Rycke
      2005
    • Behandeling van darmschade door beïnvloeding van intestinale genexpressie
      E. H. H. M. Rings
      Tijdschrift voor kindergeneeskunde 2005 73 5
    • Guanylyl cyclase C as a biomarker for immunotherapies for the treatment of gastrointestinal malignancies
      John C Flickinger, Jeffrey A Rappaport, Joshua R Barton, Trevor R Baybutt, Amanda M Pattison, Adam E Snook, Scott A Waldman
      Biomarkers in Medicine 2021
    • Guanylyl cyclase C ligands confer resistance to colorectal cancer
      Scott A Waldman, Leonid V Zingman, Denice M Hodgson, Alexey E Alekseev, Shiva Kazerounian, Martin Bienengraeber, Gyorgy Hajnóczky, Andre Terzic, Giovanni M Pitari
      BMC News and views 2003 3 S2
    • Nanoformulations in Human Health
      Biswajit Mukherjee, Samrat Chakraborty, Iman Ehsan, Apala Chakraborty, Leena Kumari, Alankar Mukherjee, Shounak Sarkhel
      2020
    • Sex Modulates Intestinal Transformation by the Tumor-Suppressor GCC
      Peng Li, Stephanie Schulz, Giovanni M. Pitari, Scott A. Waldman
      Clinical and Translational Science 2008 1 2
    • WITHDRAWN: Expression and functional characterization of guanylyl cyclase C receptor in HepG2 cells: Two-step regulation by dexamethasone and hepatocyte nuclear factor 4 (HNF4)
      Arindam Basu
      The Journal of Steroid Biochemistry and Molecular Biology 2012

    Article usage

    Article usage: July 2001 to January 2021

    AbstractFullPdf
    Jul 2001336267314
    Aug 200116114103
    Sep 2001146546
    Oct 200167064
    Nov 200196850
    Dec 2001115634
    Total 2001392640611
    Jan 200255627
    Feb 200263527
    Mar 200295934
    Apr 200263735
    May 200253135
    Jun 2002263639
    Jul 200263320
    Aug 200282439
    Sep 200251712
    Oct 200242019
    Nov 200282920
    Dec 200231611
    Total 200291393318
    Jan 200352212
    Feb 20034988151
    Mar 2003183443
    Apr 2003183022
    May 200392831
    Jun 200352517
    Jul 2003153331
    Aug 2003213219
    Sep 2003224131
    Oct 2003252621
    Nov 2003183930
    Dec 2003243038
    Total 2003229428446
    Jan 2004212619
    Feb 2004143312
    Mar 2004243229
    Apr 2004213038
    May 2004264324
    Jun 2004325419
    Jul 2004183519
    Aug 2004213113
    Sep 2004243222
    Oct 2004253511
    Nov 2004223011
    Dec 2004264011
    Total 2004274421228
    Jan 2005104710
    Feb 2005122312
    Mar 200583015
    Apr 200511237
    May 200582319
    Jun 2005101414
    Jul 20058288
    Aug 2005102812
    Sep 200571813
    Oct 200510188
    Nov 2005143319
    Dec 2005181711
    Total 2005126302148
    Jan 200616235
    Feb 200620437
    Mar 200622112
    Apr 20066229
    May 200641210
    Jun 200681510
    Jul 200651511
    Aug 20063148
    Sep 200613105
    Oct 2006142215
    Nov 200612178
    Dec 2006191710
    Total 2006122231110
    Jan 200712137
    Feb 200762310
    Mar 2007121715
    Apr 200771915
    May 200712711
    Jun 20075710
    Jul 20077711
    Aug 2007191212
    Sep 20077138
    Oct 20074128
    Nov 200712810
    Dec 200714169
    Total 2007117154126
    Jan 20087189
    Feb 2008687
    Mar 2008979
    Apr 2008211110
    May 2008784
    Jun 2008251712
    Jul 200824810
    Aug 200821195
    Sep 20083796
    Oct 2008381414
    Nov 20085736
    Dec 200833107
    Total 200828513299
    Jan 20091847
    Feb 20092995
    Mar 2009261212
    Apr 2009221613
    May 20091655
    Jun 200936138
    Jul 20099208
    Aug 20091474
    Sep 200915149
    Oct 20092498
    Nov 20091377
    Dec 20091543
    Total 200923712089
    Jan 20102975
    Feb 20102387
    Mar 20101646
    Apr 2010933
    May 20101754
    Jun 20101531
    Jul 201014126
    Aug 20101655
    Sep 201025126
    Oct 201018149
    Nov 20101764
    Dec 20101442
    Total 20102138358
    Jan 20111584
    Feb 201116134
    Mar 201118511
    Apr 2011961
    May 201114313
    Jun 20112267
    Jul 20113619
    Aug 20112439
    Sep 20111875
    Oct 20113482
    Nov 20114067
    Dec 20111852
    Total 20112647174
    Jan 20122134
    Feb 20123379
    Mar 20124586
    Apr 20124564
    May 20124152
    Jun 20124547
    Jul 20123125
    Aug 20122322
    Sep 201240113
    Oct 20122185
    Nov 20122637
    Dec 20122397
    Total 20123946861
    Jan 20133198
    Feb 201326520
    Mar 201325517
    Apr 20134896
    May 2013431010
    Jun 201333112
    Jul 201326154
    Aug 2013272816
    Sep 201319134
    Oct 20131774
    Nov 201324316
    Dec 20133485
    Total 2013353151102
    Jan 20144078
    Feb 201421819
    Mar 201411512
    Apr 201415487
    May 20142429
    Jun 2014151128
    Jul 20143747
    Aug 201424234
    Sep 201440288
    Oct 201435268
    Nov 20141086
    Dec 201413127
    Total 2014285182123
    Jan 2015735
    Feb 2015837
    Mar 20152889
    Apr 20151519
    May 201515615
    Jun 201521013
    Jul 20151845
    Aug 201512215
    Sep 201530110
    Oct 20151103
    Nov 2015919
    Dec 201521310
    Total 201519532110
    Jan 20162198
    Feb 20161306
    Mar 20161335
    Apr 20161344
    May 2016832
    Jun 20161928
    Jul 20162044
    Aug 20161604
    Sep 20161232
    Oct 20162625
    Nov 20161423
    Dec 20162136
    Total 20161963557
    Jan 201722112
    Feb 20171243
    Mar 20171615
    Apr 2017811
    May 20171454
    Jun 20172394
    Jul 20171164
    Aug 201720102
    Sep 20171056
    Oct 2017779
    Nov 20171244
    Dec 2017261
    Total 20171575955
    Jan 2018833
    Feb 2018554
    Mar 201814193
    Apr 201812112
    May 201814154
    Jun 201819153
    Jul 201811228
    Aug 201814152
    Sep 201813133
    Oct 20185157
    Nov 20184225
    Dec 20181134
    Total 201812016848
    Jan 20193132
    Feb 2019585
    Mar 20194198
    Apr 20195158
    May 20192103
    Jun 20192148
    Jul 201931310
    Aug 20190109
    Sep 20193134
    Oct 20194188
    Nov 20192139
    Dec 201942010
    Total 20193716684
    Jan 20203155
    Feb 2020174
    Mar 20201205
    Apr 20205444
    May 2020387
    Jun 2020163
    Jul 2020293
    Aug 20201810
    Sep 202031917
    Oct 20209205
    Nov 2020985
    Dec 2020131611
    Total 20205118079
    Jan 202111310
    Total 202111310
    Total413940293036
    PreviousNext
    Back to top
    Article Alerts
    Email Article

    Thank you for your interest in spreading the word on PNAS.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells
    (Your Name) has sent you a message from PNAS
    (Your Name) thought you would like to see the PNAS web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Citation Tools
    Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells
    G. M. Pitari, M. D. Di Guglielmo, J. Park, S. Schulz, S. A. Waldman
    Proceedings of the National Academy of Sciences Jul 2001, 98 (14) 7846-7851; DOI: 10.1073/pnas.141124698

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Request Permissions
    Share
    Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells
    G. M. Pitari, M. D. Di Guglielmo, J. Park, S. Schulz, S. A. Waldman
    Proceedings of the National Academy of Sciences Jul 2001, 98 (14) 7846-7851; DOI: 10.1073/pnas.141124698
    Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
    • Tweet Widget
    • Facebook Like
    • Mendeley logo Mendeley
    Proceedings of the National Academy of Sciences: 98 (14)
    Table of Contents

    Submit

    Sign up for Article Alerts

    Jump to section

    • Article
      • Abstract
      • Materials and Methods
      • Results
      • Discussion
      • Acknowledgments
      • Footnotes
      • Abbreviations
      • References
    • Figures & SI
    • Info & Metrics
    • PDF

    You May Also be Interested in

    Abstract depiction of a guitar and musical note
    Science & Culture: At the nexus of music and medicine, some see disease treatments
    Although the evidence is still limited, a growing body of research suggests music may have beneficial effects for diseases such as Parkinson’s.
    Image credit: Shutterstock/agsandrew.
    Large piece of gold
    News Feature: Tracing gold's cosmic origins
    Astronomers thought they’d finally figured out where gold and other heavy elements in the universe came from. In light of recent results, they’re not so sure.
    Image credit: Science Source/Tom McHugh.
    Dancers in red dresses
    Journal Club: Friends appear to share patterns of brain activity
    Researchers are still trying to understand what causes this strong correlation between neural and social networks.
    Image credit: Shutterstock/Yeongsik Im.
    White and blue bird
    Hazards of ozone pollution to birds
    Amanda Rodewald, Ivan Rudik, and Catherine Kling talk about the hazards of ozone pollution to birds.
    Listen
    Past PodcastsSubscribe
    Goats standing in a pin
    Transplantation of sperm-producing stem cells
    CRISPR-Cas9 gene editing can improve the effectiveness of spermatogonial stem cell transplantation in mice and livestock, a study finds.
    Image credit: Jon M. Oatley.

    Similar Articles

    Site Logo
    Powered by HighWire
    • Submit Manuscript
    • Twitter
    • Facebook
    • RSS Feeds
    • Email Alerts

    Articles

    • Current Issue
    • Special Feature Articles – Most Recent
    • List of Issues

    PNAS Portals

    • Anthropology
    • Chemistry
    • Classics
    • Front Matter
    • Physics
    • Sustainability Science
    • Teaching Resources

    Information

    • Authors
    • Editorial Board
    • Reviewers
    • Librarians
    • Press
    • Site Map
    • PNAS Updates

    Feedback    Privacy/Legal

    Copyright © 2021 National Academy of Sciences. Online ISSN 1091-6490