ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

^*Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138; ^†Cutaneous Oncology Unit, Dana–Farber Cancer Institute, Boston, MA 02115; and ^‡Cancer Research Center, Boston University, Boston, MA 02118

Contributed by Stuart L. Schreiber

Footnotes

↵§ To whom reprint requests should be addressed. E-mail: sls{at}slsiris.harvard.edu.

Cited By...

Article usage

Article usage: July 2001 to April 2021

	Abstract	Full	Pdf
Jul 2001	91	19	97
Aug 2001	283	331	487
Sep 2001	24	153	180
Oct 2001	33	158	170
Nov 2001	8	95	95
Dec 2001	15	102	59
Total 2001	454	858	1088
Jan 2002	5	69	76
Feb 2002	6	82	82
Mar 2002	7	64	54
Apr 2002	9	97	73
May 2002	6	54	36
Jun 2002	26	66	58
Jul 2002	5	53	51
Aug 2002	12	65	60
Sep 2002	13	54	58
Oct 2002	9	69	69
Nov 2002	9	51	48
Dec 2002	6	62	45
Total 2002	113	786	710
Jan 2003	6	43	35
Feb 2003	16	39	47
Mar 2003	4	40	37
Apr 2003	4	46	43
May 2003	7	36	42
Jun 2003	6	61	54
Jul 2003	18	55	20
Aug 2003	12	61	21
Sep 2003	28	93	40
Oct 2003	24	98	53
Nov 2003	24	82	43
Dec 2003	11	55	30
Total 2003	160	709	465
Jan 2004	27	67	42
Feb 2004	13	82	29
Mar 2004	17	63	40
Apr 2004	16	52	37
May 2004	18	69	31
Jun 2004	19	60	33
Jul 2004	11	69	25
Aug 2004	24	70	27
Sep 2004	10	56	19
Oct 2004	17	64	16
Nov 2004	20	50	45
Dec 2004	13	53	35
Total 2004	205	755	379
Jan 2005	11	48	33
Feb 2005	14	40	26
Mar 2005	6	39	31
Apr 2005	9	42	21
May 2005	7	39	14
Jun 2005	7	35	33
Jul 2005	6	26	12
Aug 2005	12	49	37
Sep 2005	11	36	11
Oct 2005	13	45	26
Nov 2005	18	50	42
Dec 2005	11	45	22
Total 2005	125	494	308
Jan 2006	11	45	18
Feb 2006	15	67	20
Mar 2006	15	53	19
Apr 2006	8	58	26
May 2006	9	45	20
Jun 2006	16	47	24
Jul 2006	14	31	21
Aug 2006	10	24	11
Sep 2006	14	33	26
Oct 2006	18	47	35
Nov 2006	28	54	42
Dec 2006	8	30	28
Total 2006	166	534	290
Jan 2007	12	54	21
Feb 2007	5	44	26
Mar 2007	10	38	32
Apr 2007	13	48	22
May 2007	16	56	30
Jun 2007	9	39	26
Jul 2007	9	46	24
Aug 2007	20	32	27
Sep 2007	15	46	22
Oct 2007	13	42	26
Nov 2007	18	38	17
Dec 2007	13	35	25
Total 2007	153	518	298
Jan 2008	12	41	24
Feb 2008	9	46	33
Mar 2008	14	25	22
Apr 2008	22	37	26
May 2008	21	38	39
Jun 2008	13	44	22
Jul 2008	54	27	30
Aug 2008	43	25	19
Sep 2008	52	30	13
Oct 2008	43	47	23
Nov 2008	57	28	22
Dec 2008	37	23	20
Total 2008	377	411	293
Jan 2009	20	27	15
Feb 2009	38	34	7
Mar 2009	46	52	35
Apr 2009	14	29	15
May 2009	26	28	13
Jun 2009	28	40	17
Jul 2009	23	40	15
Aug 2009	17	37	20
Sep 2009	23	35	24
Oct 2009	29	38	27
Nov 2009	25	39	24
Dec 2009	17	33	13
Total 2009	306	432	225
Jan 2010	17	36	18
Feb 2010	14	38	24
Mar 2010	26	48	26
Apr 2010	26	54	11
May 2010	11	42	14
Jun 2010	20	28	15
Jul 2010	16	43	20
Aug 2010	16	47	21
Sep 2010	13	51	15
Oct 2010	23	61	15
Nov 2010	29	58	22
Dec 2010	10	47	8
Total 2010	221	553	209
Jan 2011	14	38	10
Feb 2011	24	51	21
Mar 2011	16	52	28
Apr 2011	21	47	19
May 2011	16	70	30
Jun 2011	16	51	23
Jul 2011	14	40	20
Aug 2011	18	50	22
Sep 2011	24	63	15
Oct 2011	26	50	19
Nov 2011	22	64	22
Dec 2011	16	38	11
Total 2011	227	614	240
Jan 2012	58	62	18
Feb 2012	31	55	14
Mar 2012	27	65	22
Apr 2012	19	44	22
May 2012	26	50	27
Jun 2012	15	44	18
Jul 2012	23	72	19
Aug 2012	7	56	11
Sep 2012	11	41	11
Oct 2012	16	47	10
Nov 2012	21	28	22
Dec 2012	16	33	21
Total 2012	270	597	215
Jan 2013	12	36	19
Feb 2013	9	51	24
Mar 2013	17	102	45
Apr 2013	17	71	16
May 2013	20	48	25
Jun 2013	13	42	23
Jul 2013	14	27	29
Aug 2013	6	26	31
Sep 2013	23	20	33
Oct 2013	22	56	47
Nov 2013	12	54	31
Dec 2013	25	18	15
Total 2013	190	551	338
Jan 2014	10	25	18
Feb 2014	19	38	35
Mar 2014	27	36	50
Apr 2014	31	63	48
May 2014	18	23	36
Jun 2014	12	24	36
Jul 2014	26	26	26
Aug 2014	37	33	29
Sep 2014	21	28	29
Oct 2014	20	41	27
Nov 2014	10	33	39
Dec 2014	23	29	26
Total 2014	254	399	399
Jan 2015	16	21	29
Feb 2015	26	37	49
Mar 2015	10	28	33
Apr 2015	16	21	21
May 2015	5	20	19
Jun 2015	10	38	28
Jul 2015	5	19	35
Aug 2015	13	11	30
Sep 2015	16	16	23
Oct 2015	21	61	36
Nov 2015	13	32	41
Dec 2015	20	13	32
Total 2015	171	317	376
Jan 2016	25	12	41
Feb 2016	20	10	44
Mar 2016	17	16	56
Apr 2016	15	13	37
May 2016	15	13	27
Jun 2016	27	12	28
Jul 2016	21	19	12
Aug 2016	29	11	24
Sep 2016	19	11	26
Oct 2016	27	9	32
Nov 2016	19	8	35
Dec 2016	36	10	18
Total 2016	270	144	380
Jan 2017	24	10	30
Feb 2017	30	12	26
Mar 2017	30	16	5
Apr 2017	18	5	6
May 2017	16	9	4
Jun 2017	26	7	4
Jul 2017	20	20	4
Aug 2017	27	23	7
Sep 2017	14	18	6
Oct 2017	17	17	8
Nov 2017	14	5	4
Dec 2017	22	3	6
Total 2017	258	145	110
Jan 2018	16	13	4
Feb 2018	21	20	4
Mar 2018	36	40	10
Apr 2018	25	26	16
May 2018	44	38	11
Jun 2018	32	30	8
Jul 2018	38	41	9
Aug 2018	38	40	6
Sep 2018	24	25	8
Oct 2018	2	64	6
Nov 2018	3	75	21
Dec 2018	0	47	17
Total 2018	279	459	120
Jan 2019	4	52	8
Feb 2019	2	44	11
Mar 2019	7	35	21
Apr 2019	6	49	21
May 2019	6	44	16
Jun 2019	11	27	8
Jul 2019	10	41	15
Aug 2019	4	19	16
Sep 2019	6	46	10
Oct 2019	8	39	7
Nov 2019	4	18	15
Dec 2019	5	35	10
Total 2019	73	449	158
Jan 2020	5	32	11
Feb 2020	5	20	5
Mar 2020	1	42	7
Apr 2020	3	18	11
May 2020	2	16	4
Jun 2020	6	13	7
Jul 2020	5	21	4
Aug 2020	0	22	6
Sep 2020	5	55	16
Oct 2020	6	38	11
Nov 2020	6	31	18
Dec 2020	7	26	8
Total 2020	51	334	108
Jan 2021	6	19	13
Feb 2021	4	19	15
Mar 2021	8	40	23
Apr 2021	10	26	7
Total 2021	28	104	58
Total	4351	10163	6767