The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

^*Cancer Immunology Division, The Peter MacCallum Cancer Institute, Trescowthick Research Laboratories, Saint Andrews Place, East Melbourne, Victoria 3002, Australia; and ^‡Tyrolean Cancer Research Institute and Institute for General and Experimental Pathology, University of Innsbruck Medical School, A-6020 Innsbruck, Austria

Edited by Paul A. Marks, Memorial Sloan–Kettering Cancer Center, New York, NY, and approved July 11, 2001 (received for review April 27, 2001)

Footnotes

This paper was submitted directly (Track II) to the PNAS office.
‡ To whom reprint requests should be addressed. E-mail: r.johnstone{at}pmci.unimelb.edu.au.

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Article usage

Article usage: September 2001 to January 2021

	Abstract	Full	Pdf
Sep 2001	254	130	401
Oct 2001	21	73	145
Nov 2001	8	108	120
Dec 2001	18	56	50
Total 2001	301	367	716
Jan 2002	2	63	63
Feb 2002	5	53	35
Mar 2002	6	40	39
Apr 2002	2	49	52
May 2002	1	44	44
Jun 2002	17	24	21
Jul 2002	11	39	45
Aug 2002	7	24	22
Sep 2002	2	24	31
Oct 2002	3	30	36
Nov 2002	2	36	26
Dec 2002	1	23	18
Total 2002	59	449	432
Jan 2003	7	23	29
Feb 2003	4	35	48
Mar 2003	0	28	32
Apr 2003	4	27	20
May 2003	3	27	24
Jun 2003	2	21	32
Jul 2003	6	27	25
Aug 2003	10	22	51
Sep 2003	27	29	64
Oct 2003	15	29	64
Nov 2003	11	29	64
Dec 2003	19	25	48
Total 2003	108	322	501
Jan 2004	12	37	43
Feb 2004	9	30	47
Mar 2004	15	55	66
Apr 2004	11	45	44
May 2004	22	47	50
Jun 2004	31	47	21
Jul 2004	43	66	9
Aug 2004	36	55	28
Sep 2004	18	33	14
Oct 2004	15	39	23
Nov 2004	21	36	32
Dec 2004	25	20	13
Total 2004	258	510	390
Jan 2005	25	33	27
Feb 2005	11	32	32
Mar 2005	15	50	31
Apr 2005	5	39	32
May 2005	11	16	15
Jun 2005	15	22	15
Jul 2005	11	29	21
Aug 2005	15	31	25
Sep 2005	13	29	21
Oct 2005	18	30	19
Nov 2005	20	43	27
Dec 2005	21	29	24
Total 2005	180	383	289
Jan 2006	15	31	17
Feb 2006	34	56	15
Mar 2006	24	57	21
Apr 2006	17	29	19
May 2006	20	26	26
Jun 2006	17	22	17
Jul 2006	22	20	16
Aug 2006	21	24	10
Sep 2006	24	27	32
Oct 2006	32	36	31
Nov 2006	31	49	45
Dec 2006	18	31	26
Total 2006	275	408	275
Jan 2007	54	38	43
Feb 2007	17	24	26
Mar 2007	46	36	46
Apr 2007	38	24	21
May 2007	27	42	34
Jun 2007	24	23	22
Jul 2007	23	23	21
Aug 2007	28	27	20
Sep 2007	15	20	25
Oct 2007	40	24	16
Nov 2007	28	14	23
Dec 2007	15	9	13
Total 2007	355	304	310
Jan 2008	23	26	37
Feb 2008	29	12	28
Mar 2008	53	17	42
Apr 2008	27	19	27
May 2008	63	24	32
Jun 2008	20	19	31
Jul 2008	52	10	22
Aug 2008	60	20	22
Sep 2008	64	22	22
Oct 2008	42	7	10
Nov 2008	80	26	25
Dec 2008	41	15	11
Total 2008	554	217	309
Jan 2009	45	15	19
Feb 2009	55	15	17
Mar 2009	20	12	17
Apr 2009	19	24	15
May 2009	55	24	19
Jun 2009	25	21	17
Jul 2009	32	27	22
Aug 2009	31	30	28
Sep 2009	31	15	14
Oct 2009	39	13	15
Nov 2009	32	17	11
Dec 2009	36	11	11
Total 2009	420	224	205
Jan 2010	38	11	12
Feb 2010	36	10	20
Mar 2010	43	21	26
Apr 2010	30	7	13
May 2010	39	10	19
Jun 2010	36	12	15
Jul 2010	39	15	17
Aug 2010	46	12	12
Sep 2010	45	16	13
Oct 2010	39	28	22
Nov 2010	38	25	19
Dec 2010	35	22	11
Total 2010	464	189	199
Jan 2011	18	25	13
Feb 2011	12	23	8
Mar 2011	29	11	12
Apr 2011	29	14	13
May 2011	42	17	28
Jun 2011	18	9	8
Jul 2011	29	21	16
Aug 2011	24	14	9
Sep 2011	37	14	14
Oct 2011	33	19	16
Nov 2011	66	18	9
Dec 2011	42	18	13
Total 2011	379	203	159
Jan 2012	35	17	16
Feb 2012	59	25	23
Mar 2012	30	11	10
Apr 2012	22	17	12
May 2012	22	18	10
Jun 2012	20	24	12
Jul 2012	23	19	20
Aug 2012	22	11	9
Sep 2012	21	11	5
Oct 2012	23	8	17
Nov 2012	20	13	8
Dec 2012	20	25	10
Total 2012	317	199	152
Jan 2013	29	29	18
Feb 2013	24	22	16
Mar 2013	46	24	16
Apr 2013	23	17	13
May 2013	30	21	12
Jun 2013	37	28	11
Jul 2013	21	26	11
Aug 2013	23	15	12
Sep 2013	17	17	14
Oct 2013	22	12	9
Nov 2013	19	22	8
Dec 2013	15	12	14
Total 2013	306	245	154
Jan 2014	20	9	14
Feb 2014	16	22	8
Mar 2014	22	21	15
Apr 2014	36	46	19
May 2014	33	15	12
Jun 2014	14	8	9
Jul 2014	28	14	9
Aug 2014	30	29	9
Sep 2014	38	39	10
Oct 2014	27	58	11
Nov 2014	34	33	9
Dec 2014	26	30	5
Total 2014	324	324	130
Jan 2015	19	40	6
Feb 2015	20	30	10
Mar 2015	29	16	7
Apr 2015	24	24	13
May 2015	29	6	4
Jun 2015	16	9	10
Jul 2015	16	5	12
Aug 2015	16	16	20
Sep 2015	56	10	8
Oct 2015	35	10	7
Nov 2015	23	10	4
Dec 2015	26	14	4
Total 2015	309	190	105
Jan 2016	39	12	11
Feb 2016	22	32	2
Mar 2016	26	15	11
Apr 2016	18	11	7
May 2016	21	5	11
Jun 2016	33	15	6
Jul 2016	36	12	7
Aug 2016	25	8	13
Sep 2016	33	18	10
Oct 2016	53	12	12
Nov 2016	30	9	3
Dec 2016	30	9	11
Total 2016	366	158	104
Jan 2017	31	15	10
Feb 2017	28	13	2
Mar 2017	32	19	5
Apr 2017	21	6	7
May 2017	13	9	8
Jun 2017	15	9	5
Jul 2017	24	10	6
Aug 2017	23	14	11
Sep 2017	18	19	12
Oct 2017	30	9	8
Nov 2017	25	25	13
Dec 2017	20	9	8
Total 2017	280	157	95
Jan 2018	20	15	13
Feb 2018	18	19	8
Mar 2018	25	26	9
Apr 2018	28	31	7
May 2018	24	33	10
Jun 2018	41	42	15
Jul 2018	35	39	12
Aug 2018	51	48	6
Sep 2018	22	24	4
Oct 2018	11	35	10
Nov 2018	10	53	31
Dec 2018	7	29	14
Total 2018	292	394	139
Jan 2019	5	26	11
Feb 2019	5	23	5
Mar 2019	7	27	8
Apr 2019	5	42	12
May 2019	11	27	8
Jun 2019	2	23	4
Jul 2019	7	22	22
Aug 2019	3	26	11
Sep 2019	4	109	5
Oct 2019	7	128	17
Nov 2019	5	13	6
Dec 2019	1	20	6
Total 2019	62	486	115
Jan 2020	5	26	6
Feb 2020	6	21	8
Mar 2020	7	123	14
Apr 2020	3	8	5
May 2020	0	17	6
Jun 2020	3	6	4
Jul 2020	3	19	4
Aug 2020	4	14	12
Sep 2020	8	32	8
Oct 2020	13	20	11
Nov 2020	9	21	9
Dec 2020	16	29	14
Total 2020	77	336	101
Jan 2021	2	7	3
Total 2021	2	7	3
Total	5688	6072	4883