Table of Contents

Biological Sciences

• Agricultural Sciences

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    A framework for sustainability science: A renovated IPAT identity

    P. E. Waggoner and J. H. Ausubel

    PNAS June 11, 2002 99 (12) 7860-7865; https://doi.org/10.1073/pnas.122235999

• Applied Biological Sciences

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    In vitro and in vivo studies of a VEGF₁₂₁/rGelonin chimeric fusion toxin targeting the neovasculature of solid tumors

    Liesbeth M. Veenendaal, Hangqing Jin, Sophia Ran, Lawrence Cheung, Nora Navone, John W. Marks, Johannes Waltenberger, Philip Thorpe, and Michael G. Rosenblum

    PNAS June 11, 2002 99 (12) 7866-7871; https://doi.org/10.1073/pnas.122157899

• Biochemistry

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    In vitro formation of a c-type cytochrome

    Oliver Daltrop, James W. A. Allen, Anthony C. Willis, and Stuart J. Ferguson

    PNAS June 11, 2002 99 (12) 7872-7876; https://doi.org/10.1073/pnas.132259099
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    A monomeric red fluorescent protein

    Robert E. Campbell, Oded Tour, Amy E. Palmer, Paul A. Steinbach, Geoffrey S. Baird, David A. Zacharias, and Roger Y. Tsien

    PNAS June 11, 2002 99 (12) 7877-7882; https://doi.org/10.1073/pnas.082243699
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    Neuronal loss and brain atrophy in mice lacking cathepsins B and L

    Ute Felbor, Benedikt Kessler, Walther Mothes, Hans H. Goebel, Hidde L. Ploegh, Roderick T. Bronson, and Bjorn R. Olsen

    PNAS June 11, 2002 99 (12) 7883-7888; https://doi.org/10.1073/pnas.112632299
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    Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0

    Ryan Hagglund and Bernard Roizman

    PNAS June 11, 2002 99 (12) 7889-7894; https://doi.org/10.1073/pnas.122246999
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    Domain movements in human fatty acid synthase by quantized elastic deformational model

    Dengming Ming, Yifei Kong, Salih J. Wakil, Jacob Brink, and Jianpeng Ma

    PNAS June 11, 2002 99 (12) 7895-7899; https://doi.org/10.1073/pnas.112222299
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    Shotgun identification of protein modifications from protein complexes and lens tissue

    Michael J. MacCoss, W. Hayes McDonald, Anita Saraf, Rovshan Sadygov, Judy M. Clark, Joseph J. Tasto, Kathleen L. Gould, Dirk Wolters, Michael Washburn, Avery Weiss, John I. Clark, and John R. Yates III

    PNAS June 11, 2002 99 (12) 7900-7905; https://doi.org/10.1073/pnas.122231399
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    RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA

    Daniel P. Morse, P. Joseph Aruscavage, and Brenda L. Bass

    PNAS June 11, 2002 99 (12) 7906-7911; https://doi.org/10.1073/pnas.112704299
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    p38 is essential for the assembly and stability of macromolecular tRNA synthetase complex: Implications for its physiological significance

    Jin Young Kim, Young-Sun Kang, Joong-Won Lee, Hyoung June Kim, Young Ha Ahn, Heonyong Park, Young-Gyu Ko, and Sunghoon Kim

    PNAS June 11, 2002 99 (12) 7912-7916; https://doi.org/10.1073/pnas.122110199
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    The RecA proteins of Deinococcus radiodurans and Escherichia coli promote DNA strand exchange via inverse pathways

    Jong-Il Kim and Michael M. Cox

    PNAS June 11, 2002 99 (12) 7917-7921; https://doi.org/10.1073/pnas.122218499
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    A theoretical examination of the factors controlling the catalytic efficiency of the DNA-(adenine-N⁶)-methyltransferase from Thermus aquaticus

    Zachary E. R. Newby, Edmond Y. Lau, and Thomas C. Bruice

    PNAS June 11, 2002 99 (12) 7922-7927; https://doi.org/10.1073/pnas.122231499
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    TAR RNA loop: A scaffold for the assembly of a regulatory switch in HIV replication

    Sara Richter, Yueh-Hsin Ping, and Tariq M. Rana

    PNAS June 11, 2002 99 (12) 7928-7933; https://doi.org/10.1073/pnas.122119999
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    Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo

    Dipali Sharma and Joseph D. Fondell

    PNAS June 11, 2002 99 (12) 7934-7939; https://doi.org/10.1073/pnas.122004799
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    Coactivator/corepressor ratios modulate PR-mediated transcription by the selective receptor modulator RU486

    Zheng Liu, Didier Auboeuf, Jiemin Wong, J. Don Chen, Sophia Y. Tsai, Ming-Jer Tsai, and Bert W. O'Malley

    PNAS June 11, 2002 99 (12) 7940-7944; https://doi.org/10.1073/pnas.122225699
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    MEKK1 plays a critical role in activating the transcription factor C/EBP-β-dependent gene expression in response to IFN-γ

    Sanjit K. Roy, Junbo Hu, Qingjun Meng, Ying Xia, Paul S. Shapiro, Sekhar P. M. Reddy, Leonidas C. Platanias, Daniel J. Lindner, Peter F. Johnson, Catrin Pritchard, Gilles Pagés, Jacques Pouyssegur, and Dhananjaya V. Kalvakolanu

    PNAS June 11, 2002 99 (12) 7945-7950; https://doi.org/10.1073/pnas.122075799
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    Direct, activating interaction between glycogen synthase kinase-3β and p53 after DNA damage

    Piyajit Watcharasit, Gautam N. Bijur, Jaroslaw W. Zmijewski, Ling Song, Anna Zmijewska, Xinbin Chen, Gail V. W. Johnson, and Richard S. Jope

    PNAS June 11, 2002 99 (12) 7951-7955; https://doi.org/10.1073/pnas.122062299
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    HIV type 1 Gag virus-like particle budding from spheroplasts of Saccharomyces cerevisiae

    Sayuri Sakuragi, Toshiyuki Goto, Kouichi Sano, and Yuko Morikawa

    PNAS June 11, 2002 99 (12) 7956-7961; https://doi.org/10.1073/pnas.082281199
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    Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex

    Joseph N. McLaughlin, Craig D. Thulin, Sarah J. Hart, Katheryn A. Resing, Natalie G. Ahn, and Barry M. Willardson

    PNAS June 11, 2002 99 (12) 7962-7967; https://doi.org/10.1073/pnas.112075699
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    The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum

    Tin-Wein Yu, Linquan Bai, Dorothee Clade, Dietmar Hoffmann, Sabine Toelzer, Khue Q. Trinh, Jun Xu, Steven J. Moss, Eckhard Leistner, and Heinz G. Floss

    PNAS June 11, 2002 99 (12) 7968-7973; https://doi.org/10.1073/pnas.092697199
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    Preferential cleavage of plasmid-based R-loops and D-loops by Drosophila topoisomerase IIIβ

    Tina Wilson-Sali and Tao-shih Hsieh

    PNAS June 11, 2002 99 (12) 7974-7979; https://doi.org/10.1073/pnas.122007999

• Biophysics

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    Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus

    Dong Hae Shin, Hisao Yokota, Rosalind Kim, and Sung-Hou Kim

    PNAS June 11, 2002 99 (12) 7980-7985; https://doi.org/10.1073/pnas.132241399
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    Obligatory heterotetramerization of three previously uncharacterized Kv channel α-subunits identified in the human genome

    N. Ottschytsch, A. Raes, D. Van Hoorick, and D. J. Snyders

    PNAS June 11, 2002 99 (12) 7986-7991; https://doi.org/10.1073/pnas.122617999
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    Ligand binding and protein dynamics in neuroglobin

    Jan M. Kriegl, Aninda J. Bhattacharyya, Karin Nienhaus, Pengchi Deng, Oleksandr Minkow, and G. Ulrich Nienhaus

    PNAS June 11, 2002 99 (12) 7992-7997; https://doi.org/10.1073/pnas.082244399
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    Ultrafast spectroscopy reveals subnanosecond peptide conformational dynamics and validates molecular dynamics simulation

    Sebastian Spörlein, Heiko Carstens, Helmut Satzger, Christian Renner, Raymond Behrendt, Luis Moroder, Paul Tavan, Wolfgang Zinth, and Josef Wachtveitl

    PNAS June 11, 2002 99 (12) 7998-8002; https://doi.org/10.1073/pnas.122238799
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    Crystal structures of the vitamin D-binding protein and its complex with actin: Structural basis of the actin-scavenger system

    Ludovic R. Otterbein, Christophe Cosio, Philip Graceffa, and Roberto Dominguez

    PNAS June 11, 2002 99 (12) 8003-8008; https://doi.org/10.1073/pnas.122126299
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    Reduced-dimensionality NMR spectroscopy for high-throughput protein resonance assignment

    Thomas Szyperski, Deok C. Yeh, Dinesh K. Sukumaran, Hunter N. B. Moseley, and Gaetano T. Montelione

    PNAS June 11, 2002 99 (12) 8009-8014; https://doi.org/10.1073/pnas.122224599
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    Minimal principle for rotor filaments

    Marcel Wellner, Omer Berenfeld, José Jalife, and Arkady M. Pertsov

    PNAS June 11, 2002 99 (12) 8015-8018; https://doi.org/10.1073/pnas.112026199
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    Simulations of β-hairpin folding confined to spherical pores using distributed computing

    D. K. Klimov, D. Newfield, and D. Thirumalai

    PNAS June 11, 2002 99 (12) 8019-8024; https://doi.org/10.1073/pnas.072220699

• Cell Biology

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    Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ₄₂ production

    Tobias Moehlmann, Edith Winkler, Xuefeng Xia, Dieter Edbauer, Jill Murrell, Anja Capell, Christoph Kaether, Hui Zheng, Bernardino Ghetti, Christian Haass, and Harald Steiner

    PNAS June 11, 2002 99 (12) 8025-8030; https://doi.org/10.1073/pnas.112686799
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    Cell surface expression of the HIV-1 envelope glycoproteins is directed from intracellular CTLA-4-containing regulated secretory granules

    Luis R. Miranda, Brian C. Schaefer, Abraham Kupfer, Zixin Hu, and Alex Franzusoff

    PNAS June 11, 2002 99 (12) 8031-8036; https://doi.org/10.1073/pnas.122696599
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    One of the two cytoplasmic actin isoforms in Drosophila is essential

    Cynthia R. Wagner, Anthony P. Mahowald, and Kathryn G. Miller

    PNAS June 11, 2002 99 (12) 8037-8042; https://doi.org/10.1073/pnas.082235499
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    Mutational switch of an IL-6 response to an interferon-γ-like response

    Ana P. Costa-Pereira, Silvia Tininini, Birgit Strobl, Tonino Alonzi, Joerg F. Schlaak, Hayaatun Is'harc, Ida Gesualdo, Sally J. Newman, Ian M. Kerr, and Valeria Poli

    PNAS June 11, 2002 99 (12) 8043-8047; https://doi.org/10.1073/pnas.122236099
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    Integration of Runx and Smad regulatory signals at transcriptionally active subnuclear sites

    Sayyed K. Zaidi, Andrew J. Sullivan, Andre J. van Wijnen, Janet L. Stein, Gary S. Stein, and Jane B. Lian

    PNAS June 11, 2002 99 (12) 8048-8053; https://doi.org/10.1073/pnas.112664499
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    DT40 cells lacking the Ca²⁺-binding protein annexin 5 are resistant to Ca²⁺-dependent apoptosis

    Timothy E. Hawkins, Debipriya Das, Barry Young, and Stephen E. Moss

    PNAS June 11, 2002 99 (12) 8054-8059; https://doi.org/10.1073/pnas.132598099
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    A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: Its role in regulating granulosa cell mitosis

    Fumio Otsuka and Shunichi Shimasaki

    PNAS June 11, 2002 99 (12) 8060-8065; https://doi.org/10.1073/pnas.122066899
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    Proton-motive force stimulates the proteolytic activity of FtsH, a membrane-bound ATP- dependent protease in Escherichia coli

    Yoshinori Akiyama

    PNAS June 11, 2002 99 (12) 8066-8071; https://doi.org/10.1073/pnas.122616899
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    Autoinhibition of the ligand-binding site of GGA1/3 VHS domains by an internal acidic cluster-dileucine motif

    Balraj Doray, Kerry Bruns, Pradipta Ghosh, and Stuart A. Kornfeld

    PNAS June 11, 2002 99 (12) 8072-8077; https://doi.org/10.1073/pnas.082235699

• Developmental Biology

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    In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells

    Lijun Yang, Shiwu Li, Heather Hatch, Kim Ahrens, Janet G. Cornelius, Bryon E. Petersen, and Ammon B. Peck

    PNAS June 11, 2002 99 (12) 8078-8083; https://doi.org/10.1073/pnas.122210699
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    Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate

    Mariela Zirlinger, Liching Lo, Jill McMahon, Andrew P. McMahon, and David J. Anderson

    PNAS June 11, 2002 99 (12) 8084-8089; https://doi.org/10.1073/pnas.122231199
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    Hoxa 11 is upstream of Integrin α8 expression in the developing kidney

    M. Todd Valerius, Larry T. Patterson, Yuxin Feng, and S. Steven Potter

    PNAS June 11, 2002 99 (12) 8090-8095; https://doi.org/10.1073/pnas.122229199

• Ecology

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    Stable isotope signature of philopatry and dispersal in a migratory songbird

    Gary R. Graves, Christopher S. Romanek, and Alejandro Rodriguez Navarro

    PNAS June 11, 2002 99 (12) 8096-8100; https://doi.org/10.1073/pnas.082240899
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    Bioavailability of organic matter in a highly disturbed estuary: The role of detrital and algal resources

    William V. Sobczak, James E. Cloern, Alan D. Jassby, and Anke B. Müller-Solger

    PNAS June 11, 2002 99 (12) 8101-8105; https://doi.org/10.1073/pnas.122614399

• Evolution

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    Documenting a significant relationship between macroevolutionary origination rates and Phanerozoic pCO₂ levels

    James L. Cornette, Bruce S. Lieberman, and Robert H. Goldstein

    PNAS June 11, 2002 99 (12) 7832-7835; https://doi.org/10.1073/pnas.122225499
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    Latitudinal difference in biodiversity caused by higher tropical rate of increase

    Martin A. Buzas, Laurel S. Collins, and Stephen J. Culver

    PNAS June 11, 2002 99 (12) 7841-7843; https://doi.org/10.1073/pnas.122241499
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    Localized expression of a dpp/BMP2/4 ortholog in a coral embryo

    David C. Hayward, Gabrielle Samuel, Patricia C. Pontynen, Julian Catmull, Robert Saint, David J. Miller, and Eldon E. Ball

    PNAS June 11, 2002 99 (12) 8106-8111; https://doi.org/10.1073/pnas.112021499
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    A methodological bias toward overestimation of molecular evolutionary time scales

    Francisco Rodríguez-Trelles, Rosa Tarrío, and Francisco J. Ayala

    PNAS June 11, 2002 99 (12) 8112-8115; https://doi.org/10.1073/pnas.122231299
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    A gene network model accounting for development and evolution of mammalian teeth

    Isaac Salazar-Ciudad and Jukka Jernvall

    PNAS June 11, 2002 99 (12) 8116-8120; https://doi.org/10.1073/pnas.132069499
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    Intron presence–absence polymorphism in Drosophila driven by positive Darwinian selection

    Ana Llopart, Josep M. Comeron, Frédéric G. Brunet, Daniel Lachaise, and Manyuan Long

    PNAS June 11, 2002 99 (12) 8121-8126; https://doi.org/10.1073/pnas.122570299
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    Genetic consequences of sequential founder events by an island-colonizing bird

    • From the Cover

    Sonya M. Clegg, Sandie M. Degnan, Jiro Kikkawa, Craig Moritz, Arnaud Estoup, and Ian P. F. Owens

    PNAS June 11, 2002 99 (12) 8127-8132; https://doi.org/10.1073/pnas.102583399

    See companion article:

    • Founder effects and silvereyes

      - Jun 11, 2002
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    Genes encoding plastid acetyl-CoA carboxylase and 3-phosphoglycerate kinase of the Triticum/Aegilops complex and the evolutionary history of polyploid wheat

    Shaoxing Huang, Anchalee Sirikhachornkit, Xiujuan Su, Justin Faris, Bikram Gill, Robert Haselkorn, and Piotr Gornicki

    PNAS June 11, 2002 99 (12) 8133-8138; https://doi.org/10.1073/pnas.072223799
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    Survival without recovery after mass extinctions

    David Jablonski

    PNAS June 11, 2002 99 (12) 8139-8144; https://doi.org/10.1073/pnas.102163299
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    Adaptive evolution of small heat shock protein/ αB-crystallin promoter activity of the blind subterranean mole rat, Spalax ehrenbergi

    R. B. Hough, A. Avivi, J. Davis, A. Joel, E. Nevo, and J. Piatigorsky

    PNAS June 11, 2002 99 (12) 8145-8150; https://doi.org/10.1073/pnas.122231099
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    Mammalian mitogenomic relationships and the root of the eutherian tree

    Ulfur Arnason, Joseph A. Adegoke, Kristina Bodin, Erik W. Born, Yuzine B. Esa, Anette Gullberg, Maria Nilsson, Roger V. Short, Xiufeng Xu, and Axel Janke

    PNAS June 11, 2002 99 (12) 8151-8156; https://doi.org/10.1073/pnas.102164299
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    Genetic determination of the queen caste in an ant hybrid zone

    Glennis E. Julian, Jennifer H. Fewell, Jürgen Gadau, Robert A. Johnson, and Debbie Larrabee

    PNAS June 11, 2002 99 (12) 8157-8160; https://doi.org/10.1073/pnas.112222099

• Genetics

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    Attenuated APC alleles produce functional protein from internal translation initiation

    Kathleen Heppner Goss, Chris Trzepacz, Thérèse M. F. Tuohy, and Joanna Groden

    PNAS June 11, 2002 99 (12) 8161-8166; https://doi.org/10.1073/pnas.112072199
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    Quantitative prediction of NF-κB DNA– protein interactions

    Irina A. Udalova, Richard Mott, Dawn Field, and Dominic Kwiatkowski

    PNAS June 11, 2002 99 (12) 8167-8172; https://doi.org/10.1073/pnas.102674699
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    Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

    Craig H. Bassing, Katrin F. Chua, JoAnn Sekiguchi, Heikyung Suh, Scott R. Whitlow, James C. Fleming, Brianna C. Monroe, David N. Ciccone, Catherine Yan, Katerina Vlasakova, David M. Livingston, David O. Ferguson, Ralph Scully, and Frederick W. Alt

    PNAS June 11, 2002 99 (12) 8173-8178; https://doi.org/10.1073/pnas.122228699
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    Comparative genomic analysis in the region of a major Plasmodium-refractoriness locus of Anopheles gambiae

    Dana Thomasová, Lucas Q. Ton, Richard R. Copley, Evgeny M. Zdobnov, Xuelan Wang, Young S. Hong, Cheolho Sim, Peer Bork, Fotis C. Kafatos, and Frank H. Collins

    PNAS June 11, 2002 99 (12) 8179-8184; https://doi.org/10.1073/pnas.082235599
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    Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation

    Sebastián Kadener, Juan Pablo Fededa, Michael Rosbash, and Alberto R. Kornblihtt

    PNAS June 11, 2002 99 (12) 8185-8190; https://doi.org/10.1073/pnas.122246099
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    Constitutive telomerase expression promotes mammary carcinomas in aging mice

    Steven E. Artandi, Scott Alson, Maja K. Tietze, Norman E. Sharpless, Siqin Ye, Roger A. Greenberg, Diego H. Castrillon, James W. Horner, Sarah R. Weiler, Ruben D. Carrasco, and Ronald A. DePinho

    PNAS June 11, 2002 99 (12) 8191-8196; https://doi.org/10.1073/pnas.112515399

• Immunology

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    Inhibition of glycolipid shedding rescues recognition of a CD1⁺ T cell lymphoma by natural killer T (NKT) cells

    Venkataraman Sriram, Sungyoo Cho, Ping Li, Patrick W. O'Donnell, Claire Dunn, Kyoko Hayakawa, Janice S. Blum, and Randy R. Brutkiewicz

    PNAS June 11, 2002 99 (12) 8197-8202; https://doi.org/10.1073/pnas.122636199
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    Allogeneic β-islet cells correct diabetes and resist immune rejection

    Marcus Pericin, Alana Althage, Stefan Freigang, Hans Hengartner, Eric Rolland, Philippe Dupraz, Bernard Thorens, Patrick Aebischer, and Rolf M. Zinkernagel

    PNAS June 11, 2002 99 (12) 8203-8206; https://doi.org/10.1073/pnas.122241299
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    Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination

    Hans-Christian von Büdingen, Stephen L. Hauser, Antje Fuhrmann, Cameron B. Nabavi, Joy I. Lee, and Claude P. Genain

    PNAS June 11, 2002 99 (12) 8207-8212; https://doi.org/10.1073/pnas.122092499
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    Specificity requirements for selection and effector functions of CD25⁺4⁺ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice

    Shohei Hori, Matthias Haury, António Coutinho, and Jocelyne Demengeot

    PNAS June 11, 2002 99 (12) 8213-8218; https://doi.org/10.1073/pnas.122224799

• Medical Sciences

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    Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF)

    Richard P. Visconti, Charlene D. Richardson, and Thomas N. Sato

    PNAS June 11, 2002 99 (12) 8219-8224; https://doi.org/10.1073/pnas.122109599
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    X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein

    • From the Cover

    Sylvia G. Lehmann, Enzo Lalli, and Paolo Sassone-Corsi

    PNAS June 11, 2002 99 (12) 8225-8230; https://doi.org/10.1073/pnas.122044099
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    ADP ribosylation of human neutrophil peptide-1 regulates its biological properties

    Gregorino Paone, Akihiro Wada, Linda A. Stevens, Abul Matin, Toshiya Hirayama, Rodney L. Levine, and Joel Moss

    PNAS June 11, 2002 99 (12) 8231-8235; https://doi.org/10.1073/pnas.122238899
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    FLIP switches Fas-mediated glucose signaling in human pancreatic β cells from apoptosis to cell replication

    Kathrin Maedler, Adriano Fontana, Frédéric Ris, Pavel Sergeev, Christian Toso, José Oberholzer, Roger Lehmann, Felix Bachmann, Andrea Tasinato, Giatgen A. Spinas, Philippe A. Halban, and Marc Y. Donath

    PNAS June 11, 2002 99 (12) 8236-8241; https://doi.org/10.1073/pnas.122686299
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    Chromosome translocations and covert leukemic clones are generated during normal fetal development

    Hiroshi Mori, Susan M. Colman, Zhijian Xiao, Anthony M. Ford, Lyn E. Healy, Craig Donaldson, Jill M. Hows, Cristina Navarrete, and Mel Greaves

    PNAS June 11, 2002 99 (12) 8242-8247; https://doi.org/10.1073/pnas.112218799
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    A genetically clamped renin transgene for the induction of hypertension

    Kathleen M. I. Caron, Leighton R. James, Hyung-Suk Kim, Scott G. Morham, Maria Luisa S. Sequeira Lopez, R. Ariel Gomez, Timothy L. Reudelhuber, and Oliver Smithies

    PNAS June 11, 2002 99 (12) 8248-8252; https://doi.org/10.1073/pnas.112222199
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    Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice

    Tatsuaki Tsuruyama, Takuro Nakamura, Guang Jin, Munetaka Ozeki, Yoshihiro Yamada, and Hiroshi Hiai

    PNAS June 11, 2002 99 (12) 8253-8258; https://doi.org/10.1073/pnas.112202899
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    Basic FGF mediates an immediate response of articular cartilage to mechanical injury

    Tonia Vincent, Monika Hermansson, Mark Bolton, Robin Wait, and Jeremy Saklatvala

    PNAS June 11, 2002 99 (12) 8259-8264; https://doi.org/10.1073/pnas.122033199
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    Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation

    Timothy A. Chan, Zhenghe Wang, Long H. Dang, Bert Vogelstein, and Kenneth W. Kinzler

    PNAS June 11, 2002 99 (12) 8265-8270; https://doi.org/10.1073/pnas.082240999
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    Diversity and complexity of HIV-1 drug resistance: A bioinformatics approach to predicting phenotype from genotype

    Niko Beerenwinkel, Barbara Schmidt, Hauke Walter, Rolf Kaiser, Thomas Lengauer, Daniel Hoffmann, Klaus Korn, and Joachim Selbig

    PNAS June 11, 2002 99 (12) 8271-8276; https://doi.org/10.1073/pnas.112177799
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    The endocytic catalysts, Rab5a and Rab7, are tandem regulators of thyroid hormone production

    Karine Croizet-Berger, Chantal Daumerie, Marianne Couvreur, Pierre J. Courtoy, and Marie-France van den Hove

    PNAS June 11, 2002 99 (12) 8277-8282; https://doi.org/10.1073/pnas.122187699
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    PML/RARα and FLT3-ITD induce an APL-like disease in a mouse model

    Louise M. Kelly, Jeffrey L. Kutok, Ifor R. Williams, Christina L. Boulton, Sonia M. Amaral, David P. Curley, Timothy J. Ley, and D. Gary Gilliland

    PNAS June 11, 2002 99 (12) 8283-8288; https://doi.org/10.1073/pnas.122233699
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    A critical concentration of neutrophils is required for effective bacterial killing in suspension

    Yongmei Li, Arthur Karlin, John D. Loike, and Samuel C. Silverstein

    PNAS June 11, 2002 99 (12) 8289-8294; https://doi.org/10.1073/pnas.122244799
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    Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors

    Neil C. Josephson, George Vassilopoulos, Grant D. Trobridge, Greg V. Priestley, Brent L. Wood, Thalia Papayannopoulou, and David W. Russell

    PNAS June 11, 2002 99 (12) 8295-8300; https://doi.org/10.1073/pnas.122131099
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    3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/ p21 signaling pathway: Implications for diabetic nephropathy

    Farhad R. Danesh, Mehran M. Sadeghi, Nail Amro, Carrie Philips, Lixia Zeng, Sun Lin, Atul Sahai, and Yashpal S. Kanwar

    PNAS June 11, 2002 99 (12) 8301-8305; https://doi.org/10.1073/pnas.122228799
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    Identification of the enzymatic mechanism of nitroglycerin bioactivation

    • From the Cover

    Zhiqiang Chen, Jian Zhang, and Jonathan S. Stamler

    PNAS June 11, 2002 99 (12) 8306-8311; https://doi.org/10.1073/pnas.122225199

    See companion article:

    • After 130 years, the molecular mechanism of action of nitroglycerin is revealed

      - Jun 11, 2002

• Microbiology

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    Effects of the twin-arginine translocase on secretion of virulence factors, stress response, and pathogenesis

    Urs A. Ochsner, Aleksandra Snyder, Adriana I. Vasil, and Michael L. Vasil

    PNAS June 11, 2002 99 (12) 8312-8317; https://doi.org/10.1073/pnas.082238299
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    Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection

    Maria Teresa Sciortino, Brunella Taddeo, Alice P. W. Poon, Antonio Mastino, and Bernard Roizman

    PNAS June 11, 2002 99 (12) 8318-8323; https://doi.org/10.1073/pnas.122231699

    See companion article:

    • Might a vanguard of mRNAs prepare cells for the arrival of herpes simplex virus?

      - Jun 25, 2002
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    Novel kingdom-level eukaryotic diversity in anoxic environments

    Scott C. Dawson and Norman R. Pace

    PNAS June 11, 2002 99 (12) 8324-8329; https://doi.org/10.1073/pnas.062169599
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    Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative σ factor, SigH

    Deepak Kaushal, Benjamin G. Schroeder, Sandeep Tyagi, Tetsuyuki Yoshimatsu, Cherise Scott, Chiew Ko, Liane Carpenter, Jyoti Mehrotra, Yukari C. Manabe, Robert D. Fleischmann, and William R. Bishai

    PNAS June 11, 2002 99 (12) 8330-8335; https://doi.org/10.1073/pnas.102055799
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    Direct biochemical evidence for type III secretion-dependent translocation of the AvrBs2 effector protein into plant cells

    Catharina Casper-Lindley, Douglas Dahlbeck, Eszter T. Clark, and Brian J. Staskawicz

    PNAS June 11, 2002 99 (12) 8336-8341; https://doi.org/10.1073/pnas.122220299
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    An expanded view of bacterial DNA replication

    Marie-Françoise Noirot-Gros, Etienne Dervyn, Ling Juan Wu, Peggy Mervelet, Jeffery Errington, S. Dusko Ehrlich, and Philippe Noirot

    PNAS June 11, 2002 99 (12) 8342-8347; https://doi.org/10.1073/pnas.122040799
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    Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: A soluble, secreted CD30 homologue

    Joanne Fanelli Panus, Craig A. Smith, Caroline A. Ray, Terri Davis Smith, Dhavalkumar D. Patel, and David J. Pickup

    PNAS June 11, 2002 99 (12) 8348-8353; https://doi.org/10.1073/pnas.122238599
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    Rapid genetic analysis of Helicobacter pylori gastric mucosal colonization in suckling mice

    Betty P. Guo and John J. Mekalanos

    PNAS June 11, 2002 99 (12) 8354-8359; https://doi.org/10.1073/pnas.122244899

• Neurobiology

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    Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain

    Hua-Sheng Xiao, Qiu-Hua Huang, Fang-Xiong Zhang, Lan Bao, Ying-Jin Lu, Chao Guo, Liang Yang, Wein-Jing Huang, Gang Fu, Shu-Hua Xu, Xi-Ping Cheng, Qing Yan, Zhi-Dong Zhu, Xin Zhang, Zhu Chen, Ze-Guang Han, and Xu Zhang

    PNAS June 11, 2002 99 (12) 8360-8365; https://doi.org/10.1073/pnas.122231899
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    Dendritic K⁺ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons

    Shigeo Watanabe, Dax A. Hoffman, Michele Migliore, and Daniel Johnston

    PNAS June 11, 2002 99 (12) 8366-8371; https://doi.org/10.1073/pnas.122210599
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    All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: A novel role for photoreceptor retinoids in the response to bright light?

    Dylan M. Dean, Wang Nguitragool, Andrew Miri, Sarah L. McCabe, and Anita L. Zimmerman

    PNAS June 11, 2002 99 (12) 8372-8377; https://doi.org/10.1073/pnas.122681899
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    Single-neuron correlates of subjective vision in the human medial temporal lobe

    Gabriel Kreiman, Itzhak Fried, and Christof Koch

    PNAS June 11, 2002 99 (12) 8378-8383; https://doi.org/10.1073/pnas.072194099
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    Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens

    David Robbe, Manfred Kopf, Anne Remaury, Joel Bockaert, and Olivier J. Manzoni

    PNAS June 11, 2002 99 (12) 8384-8388; https://doi.org/10.1073/pnas.122149199
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    A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP

    Varda Lev-Ram, Scott T. Wong, Daniel R. Storm, and Roger Y. Tsien

    PNAS June 11, 2002 99 (12) 8389-8393; https://doi.org/10.1073/pnas.122206399
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    A missense mutation in human fatty acid amide hydrolase associated with problem drug use

    Jack C. Sipe, Kyle Chiang, Alexandra L. Gerber, Ernest Beutler, and Benjamin F. Cravatt

    PNAS June 11, 2002 99 (12) 8394-8399; https://doi.org/10.1073/pnas.082235799
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    An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors

    Susan M. Huang, Tiziana Bisogno, Marcello Trevisani, Abdulmonem Al-Hayani, Luciano De Petrocellis, Filomena Fezza, Michele Tognetto, Timothy J. Petros, Jocelyn F. Krey, Constance J. Chu, Jeffrey D. Miller, Stephen N. Davies, Pierangelo Geppetti, J. Michael Walker, and Vincenzo Di Marzo

    PNAS June 11, 2002 99 (12) 8400-8405; https://doi.org/10.1073/pnas.122196999
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    Cerebellar role in fear-conditioning consolidation

    • From the Cover

    Benedetto Sacchetti, Elisabetta Baldi, Carlo Ambrogi Lorenzini, and Corrado Bucherelli

    PNAS June 11, 2002 99 (12) 8406-8411; https://doi.org/10.1073/pnas.112660399

    See companion article:

    • Chasing “fear memories” to the cerebellum

      - Jun 11, 2002
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    Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration

    • From the Cover

    Alka A. Vyas, Himatkumar V. Patel, Susan E. Fromholt, Marija Heffer-Lauc, Kavita A. Vyas, Jiyoung Dang, Melitta Schachner, and Ronald L. Schnaar

    PNAS June 11, 2002 99 (12) 8412-8417; https://doi.org/10.1073/pnas.072211699

    See companion article:

    • Ganglioside rafts as MAG receptors that mediate blockade of axon growth

      - Jun 11, 2002

• Pharmacology

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    Developmental expression of functional cyclooxygenases in zebrafish

    Tilo Grosser, Shamila Yusuff, Ellina Cheskis, Michael A. Pack, and Garret A. FitzGerald

    PNAS June 11, 2002 99 (12) 8418-8423; https://doi.org/10.1073/pnas.112217799

    See companion article:

    • The COXes of Danio: From mechanistic model to experimental therapeutics

      - Jul 01, 2002

• Physiology

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    Mechanism of calcium/calmodulin inhibition of rod cyclic nucleotide-gated channels

    Matthew C. Trudeau and William N. Zagotta

    PNAS June 11, 2002 99 (12) 8424-8429; https://doi.org/10.1073/pnas.122015999
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    A glutamate residue at the C terminus regulates activity of inward rectifier K⁺ channels: Implication for Andersen's syndrome

    Lei Chen, Takeharu Kawano, Sibinka Bajic, Yoshito Kaziro, Hiroshi Itoh, Jonathan J. Art, Yasuko Nakajima, and Shigehiro Nakajima

    PNAS June 11, 2002 99 (12) 8430-8435; https://doi.org/10.1073/pnas.122682899

• Plant Biology

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    Regulation of SOS1, a plasma membrane Na⁺/H⁺ exchanger in Arabidopsis thaliana, by SOS2 and SOS3

    Quan-Sheng Qiu, Yan Guo, Margaret A. Dietrich, Karen S. Schumaker, and Jian-Kang Zhu

    PNAS June 11, 2002 99 (12) 8436-8441; https://doi.org/10.1073/pnas.122224699

• Population Biology

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    Life-long sustained mortality advantage of siblings of centenarians

    Thomas T. Perls, John Wilmoth, Robin Levenson, Maureen Drinkwater, Melissa Cohen, Hazel Bogan, Erin Joyce, Stephanie Brewster, Louis Kunkel, and Annibale Puca

    PNAS June 11, 2002 99 (12) 8442-8447; https://doi.org/10.1073/pnas.122587599

• Psychology

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    Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder

    Mary Best, J. Michael Williams, and Emil F. Coccaro

    PNAS June 11, 2002 99 (12) 8448-8453; https://doi.org/10.1073/pnas.112604099