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Sex differences in the neural basis of emotional memories

Turhan Canli, John E. Desmond, Zuo Zhao, and John D. E. Gabrieli
PNAS August 6, 2002 99 (16) 10789-10794; https://doi.org/10.1073/pnas.162356599
Turhan Canli
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John E. Desmond
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Zuo Zhao
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John D. E. Gabrieli
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  1. Communicated by Gordon H. Bower, Stanford University, Stanford, CA (received for review December 18, 2001)

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Abstract

Psychological studies have found better memory in women than men for emotional events, but the neural basis for this difference is unknown. We used event-related functional MRI to assess whether sex differences in memory for emotional stimuli is associated with activation of different neural systems in men and women. Brain activation in 12 men and 12 women was recorded while they rated their experience of emotional arousal in response to neutral and emotionally negative pictures. In a recognition memory test 3 weeks after scanning, highly emotional pictures were remembered best, and remembered better by women than by men. Men and women activated different neural circuits to encode stimuli effectively into memory even when the analysis was restricted to pictures rated equally arousing by both groups. Men activated significantly more structures than women in a network that included the right amygdala, whereas women activated significantly fewer structures in a network that included the left amygdala. Women had significantly more brain regions where activation correlated with both ongoing evaluation of emotional experience and with subsequent memory for the most emotionally arousing pictures. Greater overlap in brain regions sensitive to current emotion and contributing to subsequent memory may be a neural mechanism for emotions to enhance memory more powerfully in women than in men.

Footnotes

    • ↵‡ To whom reprint requests should be sent at the present address: Department of Psychology, State University of New York, Stony Brook, NY 11794-2500. E-mail: turhan.canli{at}sunysb.edu.

  • Abbreviations

    • BA, Brodmann area

    • Received December 18, 2001.
    • Accepted June 14, 2002.
    • Copyright © 2002, The National Academy of Sciences
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    Sex differences in the neural basis of emotional memories
    Turhan Canli, John E. Desmond, Zuo Zhao, John D. E. Gabrieli
    Proceedings of the National Academy of Sciences Aug 2002, 99 (16) 10789-10794; DOI: 10.1073/pnas.162356599

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    Sex differences in the neural basis of emotional memories
    Turhan Canli, John E. Desmond, Zuo Zhao, John D. E. Gabrieli
    Proceedings of the National Academy of Sciences Aug 2002, 99 (16) 10789-10794; DOI: 10.1073/pnas.162356599
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