Table of Contents

Biological Sciences

• Agricultural Sciences

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    Optimizing grain yields reduces CH₄ emissions from rice paddy fields

    • From the Cover

    H. A. C. Denier van der Gon, M. J. Kropff, N. van Breemen, R. Wassmann, R. S. Lantin, E. Aduna, T. M. Corton, and H. H. van Laar

    PNAS September 17, 2002 99 (19) 12021-12024; https://doi.org/10.1073/pnas.192276599

    See companion article:

    • Photosynthate allocations in rice plants: Food production or atmospheric methane?

      - Sep 09, 2002
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    The mechanism of type IA topoisomerases

    • From the Cover

    N. H. Dekker, V. V. Rybenkov, M. Duguet, N. J. Crisona, N. R. Cozzarelli, D. Bensimon, and V. Croquette

    PNAS September 17, 2002 99 (19) 12126-12131; https://doi.org/10.1073/pnas.132378799

    See companion article:

    • Type IA DNA topoisomerases: Strictly one step at a time

      - Sep 09, 2002

• Applied Biological Sciences

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    Engineering growing tissues

    Eben Alsberg, Kenneth W. Anderson, Amru Albeiruti, Jon A. Rowley, and David J. Mooney

    PNAS September 17, 2002 99 (19) 12025-12030; https://doi.org/10.1073/pnas.192291499

• Biochemistry

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    The ribosome filter hypothesis

    Vincent P. Mauro and Gerald M. Edelman

    PNAS September 17, 2002 99 (19) 12031-12036; https://doi.org/10.1073/pnas.192442499
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    Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexes

    Qing Huai, Hwa-Young Kim, Yudong Liu, Yingdong Zhao, Angelo Mondragon, Jun O. Liu, and Hengming Ke

    PNAS September 17, 2002 99 (19) 12037-12042; https://doi.org/10.1073/pnas.192206699
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    Crosslinking of membrane-embedded cysteines reveals contact points in the EmrE oligomer

    Misha Soskine, Sonia Steiner-Mordoch, and Shimon Schuldiner

    PNAS September 17, 2002 99 (19) 12043-12048; https://doi.org/10.1073/pnas.192392899
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    G_βγ-independent constitutive association of G_αs with SHP-1 and angiotensin II receptor AT₂ is essential in AT₂-mediated ITIM-independent activation of SHP-1

    Ying-Hong Feng, Yan Sun, and Janice G. Douglas

    PNAS September 17, 2002 99 (19) 12049-12054; https://doi.org/10.1073/pnas.192404199
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    The binding protein of corticotropin-releasing factor: Ligand-binding site and subunit structure

    Olaf Jahn, Klaus Eckart, Olaf Brauns, Hossein Tezval, and Joachim Spiess

    PNAS September 17, 2002 99 (19) 12055-12060; https://doi.org/10.1073/pnas.192449299
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    Inhibition of hypochlorous acid-induced cellular toxicity by nitrite

    Matthew Whiteman, D. Craig Hooper, Gwen S. Scott, Hilary Koprowski, and Barry Halliwell

    PNAS September 17, 2002 99 (19) 12061-12066; https://doi.org/10.1073/pnas.152462399
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    Convergent evolution sheds light on the anti-β-elimination mechanism common to family 1 and 10 polysaccharide lyases

    Simon J. Charnock, Ian E. Brown, Johan P. Turkenburg, Gary W. Black, and Gideon J. Davies

    PNAS September 17, 2002 99 (19) 12067-12072; https://doi.org/10.1073/pnas.182431199
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    Molecular cloning and functional expression of the first insect FMRFamide receptor

    Giuseppe Cazzamali and Cornelis J. P. Grimmelikhuijzen

    PNAS September 17, 2002 99 (19) 12073-12078; https://doi.org/10.1073/pnas.192442799
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    Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest

    Rebecca L. Read, Rui G. Martinho, Shao-Win Wang, Antony M. Carr, and Chris J. Norbury

    PNAS September 17, 2002 99 (19) 12079-12084; https://doi.org/10.1073/pnas.192467799
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    The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG

    Jennifer Aurandt, Haris G. Vikis, J. Silvio Gutkind, Natalie Ahn, and Kun-Liang Guan

    PNAS September 17, 2002 99 (19) 12085-12090; https://doi.org/10.1073/pnas.142433199
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    RecX protein abrogates ATP hydrolysis and strand exchange promoted by RecA: Insights into negative regulation of homologous recombination

    R. Venkatesh, N. Ganesh, N. Guhan, M. Sreedhar Reddy, T. Chandrasekhar, and K. Muniyappa

    PNAS September 17, 2002 99 (19) 12091-12096; https://doi.org/10.1073/pnas.192178999
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    Revisiting the kinetics of nitric oxide (NO) binding to soluble guanylate cyclase: The simple NO-binding model is incorrect

    David P. Ballou, Yunde Zhao, Philip E. Brandish, and Michael A. Marletta

    PNAS September 17, 2002 99 (19) 12097-12101; https://doi.org/10.1073/pnas.192209799
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    8-Oxoguanine rearranges the active site of human topoisomerase I

    Diem-Thu Thieu Lesher, Yves Pommier, Lance Stewart, and Matthew R. Redinbo

    PNAS September 17, 2002 99 (19) 12102-12107; https://doi.org/10.1073/pnas.192282699
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    Biosynthesis of terpenes: Studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase

    Petra Adam, Stefan Hecht, Wolfgang Eisenreich, Johannes Kaiser, Tobias Gräwert, Duilio Arigoni, Adelbert Bacher, and Felix Rohdich

    PNAS September 17, 2002 99 (19) 12108-12113; https://doi.org/10.1073/pnas.182412599
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    Dual localization of human DNA topoisomerase IIIα to mitochondria and nucleus

    Yong Wang, Yi Lisa Lyu, and James C. Wang

    PNAS September 17, 2002 99 (19) 12114-12119; https://doi.org/10.1073/pnas.192449499
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    Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases

    Jürgen J. May, Nadine Kessler, Mohamed A. Marahiel, and Milton T. Stubbs

    PNAS September 17, 2002 99 (19) 12120-12125; https://doi.org/10.1073/pnas.182156699

• Biophysics

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    Physical constraints and functional characteristics of transcription factor–DNA interaction

    Ulrich Gerland, J. David Moroz, and Terence Hwa

    PNAS September 17, 2002 99 (19) 12015-12020; https://doi.org/10.1073/pnas.192693599
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    The mechanism of type IA topoisomerases

    • From the Cover

    N. H. Dekker, V. V. Rybenkov, M. Duguet, N. J. Crisona, N. R. Cozzarelli, D. Bensimon, and V. Croquette

    PNAS September 17, 2002 99 (19) 12126-12131; https://doi.org/10.1073/pnas.132378799

    See companion article:

    • Type IA DNA topoisomerases: Strictly one step at a time

      - Sep 09, 2002
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    Application of charge density methods to a protein model compound: Calculation of Coulombic intermolecular interaction energies from the experimental charge density

    Xue Li, Guang Wu, Yuriy A. Abramov, Anatoliy V. Volkov, and Philip Coppens

    PNAS September 17, 2002 99 (19) 12132-12137; https://doi.org/10.1073/pnas.192438999
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    The structural basis for the transition from Ras-GTP to Ras-GDP

    Brian E. Hall, Dafna Bar-Sagi, and Nicolas Nassar

    PNAS September 17, 2002 99 (19) 12138-12142; https://doi.org/10.1073/pnas.192453199
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    A simple method for probing the mechanical unfolding pathway of proteins in detail

    Robert B. Best, Susan B. Fowler, José L. Toca-Herrera, and Jane Clarke

    PNAS September 17, 2002 99 (19) 12143-12148; https://doi.org/10.1073/pnas.192351899
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    Protein assembly and heat stability in developing thylakoid membranes during greening

    Zoltán Kóta, László I. Horváth, Magdolna Droppa, Gábor Horváth, Tibor Farkas, and Tibor Páli

    PNAS September 17, 2002 99 (19) 12149-12154; https://doi.org/10.1073/pnas.192463899
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    The skeletal muscle Ca²⁺ release channel has an oxidoreductase-like domain

    Matthew L. Baker, Irina I. Serysheva, Serap Sencer, Yili Wu, Steven J. Ludtke, Wen Jiang, Susan L. Hamilton, and Wah Chiu

    PNAS September 17, 2002 99 (19) 12155-12160; https://doi.org/10.1073/pnas.182058899
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    A protease assay for two-photon crosscorrelation and FRET analysis based solely on fluorescent proteins

    Tobias Kohl, Katrin G. Heinze, Rene Kuhlemann, Andre Koltermann, and Petra Schwille

    PNAS September 17, 2002 99 (19) 12161-12166; https://doi.org/10.1073/pnas.192433499
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    M-FISH analysis shows that complex chromosome aberrations induced by α-particle tracks are cumulative products of localized rearrangements

    Rhona M. Anderson, David L. Stevens, and Dudley T. Goodhead

    PNAS September 17, 2002 99 (19) 12167-12172; https://doi.org/10.1073/pnas.182426799
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    Cytochrome c folding pathway: Kinetic native-state hydrogen exchange

    Linh Hoang, Sabrina Bédard, Mallela M. G. Krishna, Yan Lin, and S. Walter Englander

    PNAS September 17, 2002 99 (19) 12173-12178; https://doi.org/10.1073/pnas.152439199
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    Mechanism by which 2,2,2-trifluoroethanol/water mixtures stabilize secondary-structure formation in peptides: A molecular dynamics study

    Danilo Roccatano, Giorgio Colombo, Marco Fioroni, and Alan E. Mark

    PNAS September 17, 2002 99 (19) 12179-12184; https://doi.org/10.1073/pnas.182199699

• Cell Biology

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    Singularity in budding: A role for the evolutionarily conserved small GTPase Cdc42p

    Juliane P. Caviston, Serguei E. Tcheperegine, and Erfei Bi

    PNAS September 17, 2002 99 (19) 12185-12190; https://doi.org/10.1073/pnas.182370299
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    Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors

    Kaisa Haglund, Noriaki Shimokawa, Iwona Szymkiewicz, and Ivan Dikic

    PNAS September 17, 2002 99 (19) 12191-12196; https://doi.org/10.1073/pnas.192462299
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    Inhibition of amyloid-β aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761

    Yuan Luo, Julie V. Smith, Vijaykumar Paramasivam, Adam Burdick, Kenneth J. Curry, Justin P. Buford, Ikhlas Khan, William J. Netzer, Huaxi Xu, and Peter Butko

    PNAS September 17, 2002 99 (19) 12197-12202; https://doi.org/10.1073/pnas.182425199
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    Purification and electron microscopic visualization of functional human spliceosomes

    Zhaolan Zhou, Jeonggu Sim, Jack Griffith, and Robin Reed

    PNAS September 17, 2002 99 (19) 12203-12207; https://doi.org/10.1073/pnas.182427099
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    A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes

    Marco Gallio, Gwen Sturgill, Philip Rather, and Per Kylsten

    PNAS September 17, 2002 99 (19) 12208-12213; https://doi.org/10.1073/pnas.192138799
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    Nitrogen monoxide-mediated control of ferritin synthesis: Implications for macrophage iron homeostasis

    Sangwon Kim and Prem Ponka

    PNAS September 17, 2002 99 (19) 12214-12219; https://doi.org/10.1073/pnas.192316099
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    Mutagenesis and repair by low doses of α radiation in mammalian cells

    Theodore T. Puck, Robert Johnson, Patricia Webb, Helen Cui, Joseph G. Valdez, and Harry Crissman

    PNAS September 17, 2002 99 (19) 12220-12223; https://doi.org/10.1073/pnas.152433699
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    The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosin

    Jing-Chuan Zhang, Fernando Doñate, Xiaoping Qi, Nicholas P. Ziats, Jose C. Juarez, Andrew P. Mazar, Yuan-Ping Pang, and Keith R. McCrae

    PNAS September 17, 2002 99 (19) 12224-12229; https://doi.org/10.1073/pnas.192668299

• Developmental Biology

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    Multiple thyroid hormone-induced muscle growth and death programs during metamorphosis in Xenopus laevis

    Biswajit Das, Alexander M. Schreiber, Haochu Huang, and Donald D. Brown

    PNAS September 17, 2002 99 (19) 12230-12235; https://doi.org/10.1073/pnas.182430599
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    Experimental control of pancreatic development and maintenance

    Andrew M. Holland, Michael A. Hale, Hideaki Kagami, Robert E. Hammer, and Raymond J. MacDonald

    PNAS September 17, 2002 99 (19) 12236-12241; https://doi.org/10.1073/pnas.192255099

• Evolution

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    Directional selection is the primary cause of phenotypic diversification

    Loren H. Rieseberg, Alex Widmer, A. Michele Arntz, and John M. Burke

    PNAS September 17, 2002 99 (19) 12242-12245; https://doi.org/10.1073/pnas.192360899
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    Evolutionary analysis of Arabidopsis, cyanobacterial, and chloroplast genomes reveals plastid phylogeny and thousands of cyanobacterial genes in the nucleus

    • From the Cover

    William Martin, Tamas Rujan, Erik Richly, Andrea Hansen, Sabine Cornelsen, Thomas Lins, Dario Leister, Bettina Stoebe, Masami Hasegawa, and David Penny

    PNAS September 17, 2002 99 (19) 12246-12251; https://doi.org/10.1073/pnas.182432999

    See companion article:

    • The genomics of symbiosis: Hosts keep the baby and the bath water

      - Sep 09, 2002
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    Evidence for van der Waals adhesion in gecko setae

    • From the Cover

    Kellar Autumn, Metin Sitti, Yiching A. Liang, Anne M. Peattie, Wendy R. Hansen, Simon Sponberg, Thomas W. Kenny, Ronald Fearing, Jacob N. Israelachvili, and Robert J. Full

    PNAS September 17, 2002 99 (19) 12252-12256; https://doi.org/10.1073/pnas.192252799
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    Type III secretion systems and the evolution of mutualistic endosymbiosis

    Colin Dale, Gordon R. Plague, Ben Wang, Howard Ochman, and Nancy A. Moran

    PNAS September 17, 2002 99 (19) 12397-12402; https://doi.org/10.1073/pnas.182213299

• Genetics

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    Identifying novel transcripts and novel genes in the human genome by using novel SAGE tags

    Jianjun Chen, Miao Sun, Sanggyu Lee, Guolin Zhou, Janet D. Rowley, and San Ming Wang

    PNAS September 17, 2002 99 (19) 12257-12262; https://doi.org/10.1073/pnas.192436499
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    A functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer risk

    Immaculata De Vivo, Gordon S. Huggins, Susan E. Hankinson, Pamela J. Lescault, Marike Boezen, Graham A. Colditz, and David J. Hunter

    PNAS September 17, 2002 99 (19) 12263-12268; https://doi.org/10.1073/pnas.192172299
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    MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer

    Michiho Nishioka, Takashi Kohno, Masachika Tani, Nozomu Yanaihara, Yoshio Tomizawa, Ayaka Otsuka, Shigeru Sasaki, Keiko Kobayashi, Toshiro Niki, Arafumi Maeshima, Yoshitaka Sekido, John D. Minna, Saburo Sone, and Jun Yokota

    PNAS September 17, 2002 99 (19) 12269-12274; https://doi.org/10.1073/pnas.192445899

• Immunology

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    Identification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cells

    Javier Hernández, Francisco García-Pons, Yu Chun Lone, Huseyin Firat, Joseph D. Schmidt, Pierre Langlade-Demoyen, and Maurizio Zanetti

    PNAS September 17, 2002 99 (19) 12275-12280; https://doi.org/10.1073/pnas.182418399
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    STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation

    Akio Morinobu, Massimo Gadina, Warren Strober, Roberta Visconti, Albert Fornace, Cristina Montagna, Gerald M. Feldman, Ryuta Nishikomori, and John J. O'Shea

    PNAS September 17, 2002 99 (19) 12281-12286; https://doi.org/10.1073/pnas.182618999
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    Tumor necrosis factor-α regulation of CD4⁺C25⁺ T cell levels in NOD mice

    Ava J. Wu, Hong Hua, Sibyl H. Munson, and Hugh O. McDevitt

    PNAS September 17, 2002 99 (19) 12287-12292; https://doi.org/10.1073/pnas.172382999
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    Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

    Yoshiko Iwai, Masayoshi Ishida, Yoshimasa Tanaka, Taku Okazaki, Tasuku Honjo, and Nagahiro Minato

    PNAS September 17, 2002 99 (19) 12293-12297; https://doi.org/10.1073/pnas.192461099
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    Role of the C-terminal propeptide in the activity and maturation of γ-interferon-inducible lysosomal thiol reductase (GILT)

    Uyen T. Phan, Rebecca L. Lackman, and Peter Cresswell

    PNAS September 17, 2002 99 (19) 12298-12303; https://doi.org/10.1073/pnas.182430499
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    Somatic hypermutation of the AID transgene in B and non-B cells

    Alberto Martin and Matthew D. Scharff

    PNAS September 17, 2002 99 (19) 12304-12308; https://doi.org/10.1073/pnas.192442899
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    Regulation of V(D)J recombination: A dominant role for promoter positioning in gene segment accessibility

    Michael L. Sikes, Amber Meade, Rajkamal Tripathi, Michael S. Krangel, and Eugene M. Oltz

    PNAS September 17, 2002 99 (19) 12309-12314; https://doi.org/10.1073/pnas.182166699

• Medical Sciences

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    Ubiquitination of inducible nitric oxide synthase is required for its degradation

    Pawel J. Kolodziejski, Aleksandra Musial, Ja-Seok Koo, and N. Tony Eissa

    PNAS September 17, 2002 99 (19) 12315-12320; https://doi.org/10.1073/pnas.192345199
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    Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: Evidence that Yfh1p affects Fe-S cluster synthesis

    Opal S. Chen, Shawn Hemenway, and Jerry Kaplan

    PNAS September 17, 2002 99 (19) 12321-12326; https://doi.org/10.1073/pnas.192449599
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    Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis

    Derrick J. Rossi, Antti Ylikorkala, Nina Korsisaari, Reijo Salovaara, Keijo Luukko, Virpi Launonen, Mark Henkemeyer, Ari Ristimäki, Lauri A. Aaltonen, and Tomi P. Mäkelä

    PNAS September 17, 2002 99 (19) 12327-12332; https://doi.org/10.1073/pnas.192301399
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    Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

    Gianluigi Condorelli, Alessandra Drusco, Giorgio Stassi, Alfonso Bellacosa, Roberta Roncarati, Guido Iaccarino, Matteo A. Russo, Yusu Gu, Nancy Dalton, Clarence Chung, Michael V. G. Latronico, Claudio Napoli, Junichi Sadoshima, Carlo M. Croce, and John Ross Jr.

    PNAS September 17, 2002 99 (19) 12333-12338; https://doi.org/10.1073/pnas.172376399
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    Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo

    Sheng Zhou, John J. Morris, Yuxiao Barnes, Lubin Lan, John D. Schuetz, and Brian P. Sorrentino

    PNAS September 17, 2002 99 (19) 12339-12344; https://doi.org/10.1073/pnas.192276999
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    Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function

    Nadia Hubert and Matthias W. Hentze

    PNAS September 17, 2002 99 (19) 12345-12350; https://doi.org/10.1073/pnas.192423399
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    Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation

    Luis Ulloa, Mahendar Ochani, Huan Yang, Mahira Tanovic, Daniel Halperin, Runkuan Yang, Christopher J. Czura, Mitchell P. Fink, and Kevin J. Tracey

    PNAS September 17, 2002 99 (19) 12351-12356; https://doi.org/10.1073/pnas.192222999
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    Integrated classification of lung tumors and cell lines by expression profiling

    Carl Virtanen, Yuichi Ishikawa, Daisuke Honjoh, Mami Kimura, Miyuki Shimane, Tatsu Miyoshi, Hitoshi Nomura, and Michael H. Jones

    PNAS September 17, 2002 99 (19) 12357-12362; https://doi.org/10.1073/pnas.192240599
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    A role for glutathione peroxidase in protecting pancreatic β cells against oxidative stress in a model of glucose toxicity

    Yoshito Tanaka, Phuong Oanh T. Tran, Jamie Harmon, and R. Paul Robertson

    PNAS September 17, 2002 99 (19) 12363-12368; https://doi.org/10.1073/pnas.192445199

• Microbiology

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    A global pH sensor: Agrobacterium sensor protein ChvG regulates acid-inducible genes on its two chromosomes and Ti plasmid

    Luoping Li, Yonghui Jia, Qingming Hou, Trevor C. Charles, Eugene W. Nester, and Shen Q. Pan

    PNAS September 17, 2002 99 (19) 12369-12374; https://doi.org/10.1073/pnas.192439499
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    The two-component system BvrR/BvrS essential for Brucella abortus virulence regulates the expression of outer membrane proteins with counterparts in members of the Rhizobiaceae

    C. Guzmán-Verri, L. Manterola, A. Sola-Landa, A. Parra, A. Cloeckaert, J. Garin, J.-P. Gorvel, I. Moriyón, E. Moreno, and I. López-Goñi

    PNAS September 17, 2002 99 (19) 12375-12380; https://doi.org/10.1073/pnas.192439399
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    A p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19

    Nicola J. Philpott, Janette Gomos, Kenneth I. Berns, and Erik Falck-Pedersen

    PNAS September 17, 2002 99 (19) 12381-12385; https://doi.org/10.1073/pnas.182430299
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    Mouse transferrin receptor 1 is the cell entry receptor for mouse mammary tumor virus

    Susan R. Ross, Jason J. Schofield, Christine J. Farr, and Maja Bucan

    PNAS September 17, 2002 99 (19) 12386-12390; https://doi.org/10.1073/pnas.192360099
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    Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae

    Hervé Tettelin, Vega Masignani, Michael J. Cieslewicz, Jonathan A. Eisen, Scott Peterson, Michael R. Wessels, Ian T. Paulsen, Karen E. Nelson, Immaculada Margarit, Timothy D. Read, Lawrence C. Madoff, Alex M. Wolf, Maureen J. Beanan, Lauren M. Brinkac, Sean C. Daugherty, Robert T. DeBoy, A. Scott Durkin, James F. Kolonay, Ramana Madupu, Matthew R. Lewis, Diana Radune, Nadezhda B. Fedorova, David Scanlan, Hoda Khouri, Stephanie Mulligan, Heather A. Carty, Robin T. Cline, Susan E. Van Aken, John Gill, Maria Scarselli, Marirosa Mora, Emilia T. Iacobini, Cecilia Brettoni, Giuliano Galli, Massimo Mariani, Filippo Vegni, Domenico Maione, Daniela Rinaudo, Rino Rappuoli, John L. Telford, Dennis L. Kasper, Guido Grandi, and Claire M. Fraser

    PNAS September 17, 2002 99 (19) 12391-12396; https://doi.org/10.1073/pnas.182380799
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    Type III secretion systems and the evolution of mutualistic endosymbiosis

    Colin Dale, Gordon R. Plague, Ben Wang, Howard Ochman, and Nancy A. Moran

    PNAS September 17, 2002 99 (19) 12397-12402; https://doi.org/10.1073/pnas.182213299
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    Whole-genome comparative analysis of three phytopathogenic Xylella fastidiosa strains

    Anamitra Bhattacharyya, Stephanie Stilwagen, Natalia Ivanova, Mark D'Souza, Axel Bernal, Athanasios Lykidis, Vinayak Kapatral, Iain Anderson, Niels Larsen, Tamara Los, Gary Reznik, Eugene Selkov Jr., Theresa L. Walunas, Helene Feil, William S. Feil, Alexander Purcell, Jean-Louis Lassez, Trevor L. Hawkins, Robert Haselkorn, Ross Overbeek, Paul F. Predki, and Nikos C. Kyrpides

    PNAS September 17, 2002 99 (19) 12403-12408; https://doi.org/10.1073/pnas.132393999
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    Genomic profiles of clinical and environmental isolates of Vibrio cholerae O1 in cholera-endemic areas of Bangladesh

    Young-Gun Zo, Irma N. G. Rivera, Estelle Russek-Cohen, M. Sirajul Islam, A. K. Siddique, M. Yunus, R. Bradley Sack, Anwar Huq, and Rita R. Colwell

    PNAS September 17, 2002 99 (19) 12409-12414; https://doi.org/10.1073/pnas.192426499
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    Cloning the vaccinia virus genome as a bacterial artificial chromosome in Escherichia coli and recovery of infectious virus in mammalian cells

    Arban Domi and Bernard Moss

    PNAS September 17, 2002 99 (19) 12415-12420; https://doi.org/10.1073/pnas.192420599

• Neuroscience

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    Act locally and think globally: Intracerebral testosterone implants induce seasonal-like growth of adult avian song control circuits

    Eliot A. Brenowitz and Karin Lent

    PNAS September 17, 2002 99 (19) 12421-12426; https://doi.org/10.1073/pnas.192308799
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    Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19

    Nina Irwin, Steven Chao, Luda Goritchenko, Atsuko Horiuchi, Paul Greengard, Angus C. Nairn, and Larry I. Benowitz

    PNAS September 17, 2002 99 (19) 12427-12431; https://doi.org/10.1073/pnas.152457399
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    Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor mice

    Simona Capsoni, Sabina Giannotta, and Antonino Cattaneo

    PNAS September 17, 2002 99 (19) 12432-12437; https://doi.org/10.1073/pnas.192442999
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    Electrical and chemical synapses among parvalbumin fast-spiking GABAergic interneurons in adult mouse neocortex

    Mario Galarreta and Shaul Hestrin

    PNAS September 17, 2002 99 (19) 12438-12443; https://doi.org/10.1073/pnas.192159599
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    Cortical representation of first and second pain sensation in humans

    Markus Ploner, Joachim Gross, Lars Timmermann, and Alfons Schnitzler

    PNAS September 17, 2002 99 (19) 12444-12448; https://doi.org/10.1073/pnas.182272899
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    Serotonin mediates food-odor associative learning in the nematode Caenorhabditis elegans

    William M. Nuttley, Karen P. Atkinson-Leadbeater, and Derek van der Kooy

    PNAS September 17, 2002 99 (19) 12449-12454; https://doi.org/10.1073/pnas.192101699

• Pharmacology

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    Topical applications of caffeine or (−)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice

    Yao-Ping Lu, You-Rong Lou, Jian-Guo Xie, Qing-Yun Peng, Jie Liao, Chung S. Yang, Mou-Tuan Huang, and Allan H. Conney

    PNAS September 17, 2002 99 (19) 12455-12460; https://doi.org/10.1073/pnas.182429899
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    Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels

    Jun Chen, Guiscard Seebohm, and Michael C. Sanguinetti

    PNAS September 17, 2002 99 (19) 12461-12466; https://doi.org/10.1073/pnas.192367299
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    Chronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic mice

    Claudio Napoli, Eric Ackah, Filomena de Nigris, Piero Del Soldato, Francesco P. D'Armiento, Ettore Crimi, Mario Condorelli, and William C. Sessa

    PNAS September 17, 2002 99 (19) 12467-12470; https://doi.org/10.1073/pnas.192244499
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    Heterozygous α_2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists

    Christopher M. Tan, Matthew H. Wilson, Leigh B. MacMillan, Brian K. Kobilka, and Lee E. Limbird

    PNAS September 17, 2002 99 (19) 12471-12476; https://doi.org/10.1073/pnas.122368499

• Physiology

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    CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex

    Estelle Cormet-Boyaka, Anke Di, Steven Y. Chang, Anjaparavanda P. Naren, Albert Tousson, Deborah J. Nelson, and Kevin L. Kirk

    PNAS September 17, 2002 99 (19) 12477-12482; https://doi.org/10.1073/pnas.192203899
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    Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis

    Karin Müller-Decker, Gitta Neufang, Irina Berger, Melanie Neumann, Friedrich Marks, and Gerhard Fürstenberger

    PNAS September 17, 2002 99 (19) 12483-12488; https://doi.org/10.1073/pnas.192323799

• Plant Biology

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    Folate synthesis in plants: The first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I

    Gilles Basset, Eoin P. Quinlivan, Michael J. Ziemak, Rocío Díaz de la Garza, Markus Fischer, Susi Schiffmann, Adelbert Bacher, Jesse F. Gregory III, and Andrew D. Hanson

    PNAS September 17, 2002 99 (19) 12489-12494; https://doi.org/10.1073/pnas.192278499
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    Isolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesis

    Svetlana Porfirova, Eveline Bergmüller, Susanne Tropf, Rainer Lemke, and Peter Dörmann

    PNAS September 17, 2002 99 (19) 12495-12500; https://doi.org/10.1073/pnas.182330899