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Table of Contents
September 17, 2002; vol. 99 no. 19
Physical Sciences
Applied Physical Sciences
- You have accessTrojan particles: Large porous carriers of nanoparticles for drug deliveryN. Tsapis, D. Bennett, B. Jackson, D. A. Weitz, and D. A. Edwards
- You have accessFriction traced to the single atomFranz J. Giessibl, Markus Herz, and Jochen Mannhart
Geology
- You have accessRapid atmospheric CO2 changes associated with the 8,200-years-B.P. cooling eventFriederike Wagner, Bent Aaby, and Henk Visscher
Physics
- You have accessPhysical constraints and functional characteristics of transcription factor–DNA interactionUlrich Gerland, J. David Moroz, and Terence Hwa
Biological Sciences
Agricultural Sciences
- You have accessOptimizing grain yields reduces CH4 emissions from rice paddy fields
- From the Cover
H. A. C. Denier van der Gon, M. J. Kropff, N. van Breemen, R. Wassmann, R. S. Lantin, E. Aduna, T. M. Corton, and H. H. van LaarSee companion article:
- You have accessThe mechanism of type IA topoisomerases
- From the Cover
N. H. Dekker, V. V. Rybenkov, M. Duguet, N. J. Crisona, N. R. Cozzarelli, D. Bensimon, and V. CroquetteSee companion article:
- Type IA DNA topoisomerases: Strictly one step at a time- Sep 09, 2002
Applied Biological Sciences
- You have accessEngineering growing tissuesEben Alsberg, Kenneth W. Anderson, Amru Albeiruti, Jon A. Rowley, and David J. Mooney
Biochemistry
- You have accessCrystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin–drug complexesQing Huai, Hwa-Young Kim, Yudong Liu, Yingdong Zhao, Angelo Mondragon, Jun O. Liu, and Hengming Ke
- You have accessCrosslinking of membrane-embedded cysteines reveals contact points in the EmrE oligomerMisha Soskine, Sonia Steiner-Mordoch, and Shimon Schuldiner
- You have accessGβγ-independent constitutive association of Gαs with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-1Ying-Hong Feng, Yan Sun, and Janice G. Douglas
- You have accessThe binding protein of corticotropin-releasing factor: Ligand-binding site and subunit structureOlaf Jahn, Klaus Eckart, Olaf Brauns, Hossein Tezval, and Joachim Spiess
- You have accessInhibition of hypochlorous acid-induced cellular toxicity by nitriteMatthew Whiteman, D. Craig Hooper, Gwen S. Scott, Hilary Koprowski, and Barry Halliwell
- You have accessConvergent evolution sheds light on the anti-β-elimination mechanism common to family 1 and 10 polysaccharide lyasesSimon J. Charnock, Ian E. Brown, Johan P. Turkenburg, Gary W. Black, and Gideon J. Davies
- You have accessMolecular cloning and functional expression of the first insect FMRFamide receptorGiuseppe Cazzamali and Cornelis J. P. Grimmelikhuijzen
- You have accessCytoplasmic poly(A) polymerases mediate cellular responses to S phase arrestRebecca L. Read, Rui G. Martinho, Shao-Win Wang, Antony M. Carr, and Chris J. Norbury
- You have accessThe semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARGJennifer Aurandt, Haris G. Vikis, J. Silvio Gutkind, Natalie Ahn, and Kun-Liang Guan
- You have accessRecX protein abrogates ATP hydrolysis and strand exchange promoted by RecA: Insights into negative regulation of homologous recombinationR. Venkatesh, N. Ganesh, N. Guhan, M. Sreedhar Reddy, T. Chandrasekhar, and K. Muniyappa
- You have accessRevisiting the kinetics of nitric oxide (NO) binding to soluble guanylate cyclase: The simple NO-binding model is incorrectDavid P. Ballou, Yunde Zhao, Philip E. Brandish, and Michael A. Marletta
- You have access8-Oxoguanine rearranges the active site of human topoisomerase IDiem-Thu Thieu Lesher, Yves Pommier, Lance Stewart, and Matthew R. Redinbo
- You have accessBiosynthesis of terpenes: Studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductasePetra Adam, Stefan Hecht, Wolfgang Eisenreich, Johannes Kaiser, Tobias Gräwert, Duilio Arigoni, Adelbert Bacher, and Felix Rohdich
- You have accessDual localization of human DNA topoisomerase IIIα to mitochondria and nucleusYong Wang, Yi Lisa Lyu, and James C. Wang
- You have accessCrystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetasesJürgen J. May, Nadine Kessler, Mohamed A. Marahiel, and Milton T. Stubbs
Biophysics
- You have accessPhysical constraints and functional characteristics of transcription factor–DNA interactionUlrich Gerland, J. David Moroz, and Terence Hwa
- You have accessThe mechanism of type IA topoisomerases
- From the Cover
N. H. Dekker, V. V. Rybenkov, M. Duguet, N. J. Crisona, N. R. Cozzarelli, D. Bensimon, and V. CroquetteSee companion article:
- Type IA DNA topoisomerases: Strictly one step at a time- Sep 09, 2002
- You have accessApplication of charge density methods to a protein model compound: Calculation of Coulombic intermolecular interaction energies from the experimental charge densityXue Li, Guang Wu, Yuriy A. Abramov, Anatoliy V. Volkov, and Philip Coppens
- You have accessThe structural basis for the transition from Ras-GTP to Ras-GDPBrian E. Hall, Dafna Bar-Sagi, and Nicolas Nassar
- You have accessA simple method for probing the mechanical unfolding pathway of proteins in detailRobert B. Best, Susan B. Fowler, José L. Toca-Herrera, and Jane Clarke
- You have accessProtein assembly and heat stability in developing thylakoid membranes during greeningZoltán Kóta, László I. Horváth, Magdolna Droppa, Gábor Horváth, Tibor Farkas, and Tibor Páli
- You have accessThe skeletal muscle Ca2+ release channel has an oxidoreductase-like domainMatthew L. Baker, Irina I. Serysheva, Serap Sencer, Yili Wu, Steven J. Ludtke, Wen Jiang, Susan L. Hamilton, and Wah Chiu
- You have accessA protease assay for two-photon crosscorrelation and FRET analysis based solely on fluorescent proteinsTobias Kohl, Katrin G. Heinze, Rene Kuhlemann, Andre Koltermann, and Petra Schwille
- You have accessM-FISH analysis shows that complex chromosome aberrations induced by α-particle tracks are cumulative products of localized rearrangementsRhona M. Anderson, David L. Stevens, and Dudley T. Goodhead
- You have accessCytochrome c folding pathway: Kinetic native-state hydrogen exchangeLinh Hoang, Sabrina Bédard, Mallela M. G. Krishna, Yan Lin, and S. Walter Englander
- You have accessMechanism by which 2,2,2-trifluoroethanol/water mixtures stabilize secondary-structure formation in peptides: A molecular dynamics studyDanilo Roccatano, Giorgio Colombo, Marco Fioroni, and Alan E. Mark
Cell Biology
- You have accessSingularity in budding: A role for the evolutionarily conserved small GTPase Cdc42pJuliane P. Caviston, Serguei E. Tcheperegine, and Erfei Bi
- You have accessCbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptorsKaisa Haglund, Noriaki Shimokawa, Iwona Szymkiewicz, and Ivan Dikic
- You have accessInhibition of amyloid-β aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761Yuan Luo, Julie V. Smith, Vijaykumar Paramasivam, Adam Burdick, Kenneth J. Curry, Justin P. Buford, Ikhlas Khan, William J. Netzer, Huaxi Xu, and Peter Butko
- You have accessPurification and electron microscopic visualization of functional human spliceosomesZhaolan Zhou, Jeonggu Sim, Jack Griffith, and Robin Reed
- You have accessA conserved mechanism for extracellular signaling in eukaryotes and prokaryotesMarco Gallio, Gwen Sturgill, Philip Rather, and Per Kylsten
- You have accessNitrogen monoxide-mediated control of ferritin synthesis: Implications for macrophage iron homeostasisSangwon Kim and Prem Ponka
- You have accessMutagenesis and repair by low doses of α radiation in mammalian cellsTheodore T. Puck, Robert Johnson, Patricia Webb, Helen Cui, Joseph G. Valdez, and Harry Crissman
- You have accessThe antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosinJing-Chuan Zhang, Fernando Doñate, Xiaoping Qi, Nicholas P. Ziats, Jose C. Juarez, Andrew P. Mazar, Yuan-Ping Pang, and Keith R. McCrae
Developmental Biology
- You have accessMultiple thyroid hormone-induced muscle growth and death programs during metamorphosis in Xenopus laevisBiswajit Das, Alexander M. Schreiber, Haochu Huang, and Donald D. Brown
- You have accessExperimental control of pancreatic development and maintenanceAndrew M. Holland, Michael A. Hale, Hideaki Kagami, Robert E. Hammer, and Raymond J. MacDonald
Evolution
- You have accessDirectional selection is the primary cause of phenotypic diversificationLoren H. Rieseberg, Alex Widmer, A. Michele Arntz, and John M. Burke
- You have accessEvolutionary analysis of Arabidopsis, cyanobacterial, and chloroplast genomes reveals plastid phylogeny and thousands of cyanobacterial genes in the nucleus
- From the Cover
William Martin, Tamas Rujan, Erik Richly, Andrea Hansen, Sabine Cornelsen, Thomas Lins, Dario Leister, Bettina Stoebe, Masami Hasegawa, and David PennySee companion article:
- You have accessEvidence for van der Waals adhesion in gecko setae
- From the Cover
Kellar Autumn, Metin Sitti, Yiching A. Liang, Anne M. Peattie, Wendy R. Hansen, Simon Sponberg, Thomas W. Kenny, Ronald Fearing, Jacob N. Israelachvili, and Robert J. Full - You have accessType III secretion systems and the evolution of mutualistic endosymbiosisColin Dale, Gordon R. Plague, Ben Wang, Howard Ochman, and Nancy A. Moran
Genetics
- You have accessIdentifying novel transcripts and novel genes in the human genome by using novel SAGE tagsJianjun Chen, Miao Sun, Sanggyu Lee, Guolin Zhou, Janet D. Rowley, and San Ming Wang
- You have accessA functional polymorphism in the promoter of the progesterone receptor gene associated with endometrial cancer riskImmaculata De Vivo, Gordon S. Huggins, Susan E. Hankinson, Pamela J. Lescault, Marike Boezen, Graham A. Colditz, and David J. Hunter
- You have accessMYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancerMichiho Nishioka, Takashi Kohno, Masachika Tani, Nozomu Yanaihara, Yoshio Tomizawa, Ayaka Otsuka, Shigeru Sasaki, Keiko Kobayashi, Toshiro Niki, Arafumi Maeshima, Yoshitaka Sekido, John D. Minna, Saburo Sone, and Jun Yokota
Immunology
- You have accessIdentification of a human telomerase reverse transcriptase peptide of low affinity for HLA A2.1 that induces cytotoxic T lymphocytes and mediates lysis of tumor cellsJavier Hernández, Francisco García-Pons, Yu Chun Lone, Huseyin Firat, Joseph D. Schmidt, Pierre Langlade-Demoyen, and Maurizio Zanetti
- You have accessSTAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferationAkio Morinobu, Massimo Gadina, Warren Strober, Roberta Visconti, Albert Fornace, Cristina Montagna, Gerald M. Feldman, Ryuta Nishikomori, and John J. O'Shea
- You have accessTumor necrosis factor-α regulation of CD4+C25+ T cell levels in NOD miceAva J. Wu, Hong Hua, Sibyl H. Munson, and Hugh O. McDevitt
- You have accessInvolvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockadeYoshiko Iwai, Masayoshi Ishida, Yoshimasa Tanaka, Taku Okazaki, Tasuku Honjo, and Nagahiro Minato
- You have accessRole of the C-terminal propeptide in the activity and maturation of γ-interferon-inducible lysosomal thiol reductase (GILT)Uyen T. Phan, Rebecca L. Lackman, and Peter Cresswell
- You have accessSomatic hypermutation of the AID transgene in B and non-B cellsAlberto Martin and Matthew D. Scharff
- You have accessRegulation of V(D)J recombination: A dominant role for promoter positioning in gene segment accessibilityMichael L. Sikes, Amber Meade, Rajkamal Tripathi, Michael S. Krangel, and Eugene M. Oltz
Medical Sciences
- You have accessUbiquitination of inducible nitric oxide synthase is required for its degradationPawel J. Kolodziejski, Aleksandra Musial, Ja-Seok Koo, and N. Tony Eissa
- You have accessInhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: Evidence that Yfh1p affects Fe-S cluster synthesisOpal S. Chen, Shawn Hemenway, and Jerry Kaplan
- You have accessInduction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposisDerrick J. Rossi, Antti Ylikorkala, Nina Korsisaari, Reijo Salovaara, Keijo Luukko, Virpi Launonen, Mark Henkemeyer, Ari Ristimäki, Lauri A. Aaltonen, and Tomi P. Mäkelä
- You have accessAkt induces enhanced myocardial contractility and cell size in vivo in transgenic miceGianluigi Condorelli, Alessandra Drusco, Giorgio Stassi, Alfonso Bellacosa, Roberta Roncarati, Guido Iaccarino, Matteo A. Russo, Yusu Gu, Nancy Dalton, Clarence Chung, Michael V. G. Latronico, Claudio Napoli, Junichi Sadoshima, Carlo M. Croce, and John Ross Jr.
- You have accessBcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivoSheng Zhou, John J. Morris, Yuxiao Barnes, Lubin Lan, John D. Schuetz, and Brian P. Sorrentino
- You have accessPreviously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular functionNadia Hubert and Matthias W. Hentze
- You have accessEthyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammationLuis Ulloa, Mahendar Ochani, Huan Yang, Mahira Tanovic, Daniel Halperin, Runkuan Yang, Christopher J. Czura, Mitchell P. Fink, and Kevin J. Tracey
- You have accessIntegrated classification of lung tumors and cell lines by expression profilingCarl Virtanen, Yuichi Ishikawa, Daisuke Honjoh, Mami Kimura, Miyuki Shimane, Tatsu Miyoshi, Hitoshi Nomura, and Michael H. Jones
- You have accessA role for glutathione peroxidase in protecting pancreatic β cells against oxidative stress in a model of glucose toxicityYoshito Tanaka, Phuong Oanh T. Tran, Jamie Harmon, and R. Paul Robertson
Microbiology
- You have accessA global pH sensor: Agrobacterium sensor protein ChvG regulates acid-inducible genes on its two chromosomes and Ti plasmidLuoping Li, Yonghui Jia, Qingming Hou, Trevor C. Charles, Eugene W. Nester, and Shen Q. Pan
- You have accessThe two-component system BvrR/BvrS essential for Brucella abortus virulence regulates the expression of outer membrane proteins with counterparts in members of the RhizobiaceaeC. Guzmán-Verri, L. Manterola, A. Sola-Landa, A. Parra, A. Cloeckaert, J. Garin, J.-P. Gorvel, I. Moriyón, E. Moreno, and I. López-Goñi
- You have accessA p5 integration efficiency element mediates Rep-dependent integration into AAVS1 at chromosome 19Nicola J. Philpott, Janette Gomos, Kenneth I. Berns, and Erik Falck-Pedersen
- You have accessMouse transferrin receptor 1 is the cell entry receptor for mouse mammary tumor virusSusan R. Ross, Jason J. Schofield, Christine J. Farr, and Maja Bucan
- You have accessComplete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiaeHervé Tettelin, Vega Masignani, Michael J. Cieslewicz, Jonathan A. Eisen, Scott Peterson, Michael R. Wessels, Ian T. Paulsen, Karen E. Nelson, Immaculada Margarit, Timothy D. Read, Lawrence C. Madoff, Alex M. Wolf, Maureen J. Beanan, Lauren M. Brinkac, Sean C. Daugherty, Robert T. DeBoy, A. Scott Durkin, James F. Kolonay, Ramana Madupu, Matthew R. Lewis, Diana Radune, Nadezhda B. Fedorova, David Scanlan, Hoda Khouri, Stephanie Mulligan, Heather A. Carty, Robin T. Cline, Susan E. Van Aken, John Gill, Maria Scarselli, Marirosa Mora, Emilia T. Iacobini, Cecilia Brettoni, Giuliano Galli, Massimo Mariani, Filippo Vegni, Domenico Maione, Daniela Rinaudo, Rino Rappuoli, John L. Telford, Dennis L. Kasper, Guido Grandi, and Claire M. Fraser
- You have accessType III secretion systems and the evolution of mutualistic endosymbiosisColin Dale, Gordon R. Plague, Ben Wang, Howard Ochman, and Nancy A. Moran
- You have accessWhole-genome comparative analysis of three phytopathogenic Xylella fastidiosa strainsAnamitra Bhattacharyya, Stephanie Stilwagen, Natalia Ivanova, Mark D'Souza, Axel Bernal, Athanasios Lykidis, Vinayak Kapatral, Iain Anderson, Niels Larsen, Tamara Los, Gary Reznik, Eugene Selkov Jr., Theresa L. Walunas, Helene Feil, William S. Feil, Alexander Purcell, Jean-Louis Lassez, Trevor L. Hawkins, Robert Haselkorn, Ross Overbeek, Paul F. Predki, and Nikos C. Kyrpides
- You have accessGenomic profiles of clinical and environmental isolates of Vibrio cholerae O1 in cholera-endemic areas of BangladeshYoung-Gun Zo, Irma N. G. Rivera, Estelle Russek-Cohen, M. Sirajul Islam, A. K. Siddique, M. Yunus, R. Bradley Sack, Anwar Huq, and Rita R. Colwell
- You have accessCloning the vaccinia virus genome as a bacterial artificial chromosome in Escherichia coli and recovery of infectious virus in mammalian cellsArban Domi and Bernard Moss
Neuroscience
- You have accessAct locally and think globally: Intracerebral testosterone implants induce seasonal-like growth of adult avian song control circuitsEliot A. Brenowitz and Karin Lent
- You have accessNerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19Nina Irwin, Steven Chao, Luda Goritchenko, Atsuko Horiuchi, Paul Greengard, Angus C. Nairn, and Larry I. Benowitz
- You have accessNerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor miceSimona Capsoni, Sabina Giannotta, and Antonino Cattaneo
- You have accessElectrical and chemical synapses among parvalbumin fast-spiking GABAergic interneurons in adult mouse neocortexMario Galarreta and Shaul Hestrin
- You have accessCortical representation of first and second pain sensation in humansMarkus Ploner, Joachim Gross, Lars Timmermann, and Alfons Schnitzler
- You have accessSerotonin mediates food-odor associative learning in the nematode Caenorhabditis elegansWilliam M. Nuttley, Karen P. Atkinson-Leadbeater, and Derek van der Kooy
Pharmacology
- You have accessTopical applications of caffeine or (−)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in miceYao-Ping Lu, You-Rong Lou, Jian-Guo Xie, Qing-Yun Peng, Jie Liao, Chung S. Yang, Mou-Tuan Huang, and Allan H. Conney
- You have accessPosition of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channelsJun Chen, Guiscard Seebohm, and Michael C. Sanguinetti
- You have accessChronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic miceClaudio Napoli, Eric Ackah, Filomena de Nigris, Piero Del Soldato, Francesco P. D'Armiento, Ettore Crimi, Mario Condorelli, and William C. Sessa
- You have accessHeterozygous α2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonistsChristopher M. Tan, Matthew H. Wilson, Leigh B. MacMillan, Brian K. Kobilka, and Lee E. Limbird
Physiology
- You have accessCFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complexEstelle Cormet-Boyaka, Anke Di, Steven Y. Chang, Anjaparavanda P. Naren, Albert Tousson, Deborah J. Nelson, and Kevin L. Kirk
- You have accessTransgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesisKarin Müller-Decker, Gitta Neufang, Irina Berger, Melanie Neumann, Friedrich Marks, and Gerhard Fürstenberger
Plant Biology
- You have accessFolate synthesis in plants: The first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase IGilles Basset, Eoin P. Quinlivan, Michael J. Ziemak, Rocío Díaz de la Garza, Markus Fischer, Susi Schiffmann, Adelbert Bacher, Jesse F. Gregory III, and Andrew D. Hanson
- You have accessIsolation of an Arabidopsis mutant lacking vitamin E and identification of a cyclase essential for all tocopherol biosynthesisSvetlana Porfirova, Eveline Bergmüller, Susanne Tropf, Rainer Lemke, and Peter Dörmann
Commentaries
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