Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis

    Dongfang Liu, Zachary Shriver, Ganesh Venkataraman, Yosuf El Shabrawi, and Ram Sasisekharan

    PNAS January 22, 2002 99 (2) 568-573; https://doi.org/10.1073/pnas.012578299

    See companion article:

    • Six blind men and the elephant—the many faces of heparan sulfate

      - Jan 22, 2002
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    High throughput DNA sequencing with a microfabricated 96-lane capillary array electrophoresis bioprocessor

    Brian M. Paegel, Charles A. Emrich, Gary J. Wedemayer, James R. Scherer, and Richard A. Mathies

    PNAS January 22, 2002 99 (2) 574-579; https://doi.org/10.1073/pnas.012608699

• Biochemistry

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    Abietadiene synthase catalysis: Mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement

    Reuben J. Peters and Rodney B. Croteau

    PNAS January 22, 2002 99 (2) 580-584; https://doi.org/10.1073/pnas.022627099
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    Blocking site-to-site translocation of a misactivated amino acid by mutation of a class I tRNA synthetase

    Anthony C. Bishop, Tyzoon K. Nomanbhoy, and Paul Schimmel

    PNAS January 22, 2002 99 (2) 585-590; https://doi.org/10.1073/pnas.012611299
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    Snapshot of a key intermediate in enzymatic thiamin catalysis: Crystal structure of the α-carbanion of (α,β-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae

    • From the Cover

    Erik Fiedler, Stina Thorell, Tatyana Sandalova, Ralph Golbik, Stephan König, and Gunter Schneider

    PNAS January 22, 2002 99 (2) 591-595; https://doi.org/10.1073/pnas.022510999
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    Archaeal dUTPase enhances PCR amplifications with archaeal DNA polymerases by preventing dUTP incorporation

    Holly H. Hogrefe, Connie J. Hansen, Bradley R. Scott, and Kirk B. Nielson

    PNAS January 22, 2002 99 (2) 596-601; https://doi.org/10.1073/pnas.012372799
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    Multiple hematopoietic defects and delayed globin switching in Ikaros null mice

    Rocio A. Lopez, Stuti Schoetz, Kathryn DeAngelis, David O'Neill, and Arthur Bank

    PNAS January 22, 2002 99 (2) 602-607; https://doi.org/10.1073/pnas.022412699
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    Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase

    Jian Wang, Mariliz Ortiz-Maldonado, Barrie Entsch, Vincent Massey, David Ballou, and Domenico L. Gatti

    PNAS January 22, 2002 99 (2) 608-613; https://doi.org/10.1073/pnas.022640199
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    Combinatorial approaches: A new tool to search for highly structured β-hairpin peptides

    Maria Teresa Pastor, Manuela López de la Paz, Emmanuel Lacroix, Luis Serrano, and Enrique Pérez-Payá

    PNAS January 22, 2002 99 (2) 614-619; https://doi.org/10.1073/pnas.012583999
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    Gene characterized for membrane desaturase that produces (E)-11 isomers of mono- and diunsaturated fatty acids

    Weitian Liu, Hongmei Jiao, Nancy C. Murray, Marion O'Connor, and Wendell L. Roelofs

    PNAS January 22, 2002 99 (2) 620-624; https://doi.org/10.1073/pnas.221601498
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    A mutation in the peroxisome proliferator-activated receptor γ-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice

    Yael Olswang, Hannah Cohen, Orit Papo, Hanoch Cassuto, Colleen M. Croniger, Parvin Hakimi, Shirley M. Tilghman, Richard W. Hanson, and Lea Reshef

    PNAS January 22, 2002 99 (2) 625-630; https://doi.org/10.1073/pnas.022616299
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    Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes

    Ryan Hagglund, Charles Van Sant, Pascal Lopez, and Bernard Roizman

    PNAS January 22, 2002 99 (2) 631-636; https://doi.org/10.1073/pnas.022531599
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    mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

    Dong-chul Kang, Rahul V. Gopalkrishnan, Qingping Wu, Eckhard Jankowsky, Anna Marie Pyle, and Paul B. Fisher

    PNAS January 22, 2002 99 (2) 637-642; https://doi.org/10.1073/pnas.022637199
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    Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides

    Lidija Covic, Amy L. Gresser, Joyce Talavera, Steven Swift, and Athan Kuliopulos

    PNAS January 22, 2002 99 (2) 643-648; https://doi.org/10.1073/pnas.022460899
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    Transcription-coupled repair in RNA polymerase I-transcribed genes of yeast

    Antonio Conconi, Vyacheslav A. Bespalov, and Michael J. Smerdon

    PNAS January 22, 2002 99 (2) 649-654; https://doi.org/10.1073/pnas.022373099
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    tRNA elements mediate the assembly of an icosahedral RNA virus

    Yoon Gi Choi, Theo W. Dreher, and A. L. N. Rao

    PNAS January 22, 2002 99 (2) 655-660; https://doi.org/10.1073/pnas.022618199
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    Supervillin associates with androgen receptor and modulates its transcriptional activity

    Huei-Ju Ting, Shuyuan Yeh, Kazuo Nishimura, and Chawnshang Chang

    PNAS January 22, 2002 99 (2) 661-666; https://doi.org/10.1073/pnas.022469899

• Biophysics

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    Self-assembly properties of a model RING domain

    • From the Cover

    Alex Kentsis, Ronald E. Gordon, and Katherine L. B. Borden

    PNAS January 22, 2002 99 (2) 667-672; https://doi.org/10.1073/pnas.012317299
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    Robustness of circadian rhythms with respect to molecular noise

    Didier Gonze, José Halloy, and Albert Goldbeter

    PNAS January 22, 2002 99 (2) 673-678; https://doi.org/10.1073/pnas.022628299
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    Synchronizing genetic relaxation oscillators by intercell signaling

    David McMillen, Nancy Kopell, Jeff Hasty, and J. J. Collins

    PNAS January 22, 2002 99 (2) 679-684; https://doi.org/10.1073/pnas.022642299
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    Protein folding mediated by solvation: Water expulsion and formation of the hydrophobic core occur after the structural collapse

    Margaret S. Cheung, Angel E. García, and José N. Onuchic

    PNAS January 22, 2002 99 (2) 685-690; https://doi.org/10.1073/pnas.022387699
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    Improved recognition of native-like protein structures using a family of designed sequences

    Patrice Koehl and Michael Levitt

    PNAS January 22, 2002 99 (2) 691-696; https://doi.org/10.1073/pnas.022408799
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    Function of the voltage gate of gap junction channels: Selective exclusion of molecules

    Yang Qu and Gerhard Dahl

    PNAS January 22, 2002 99 (2) 697-702; https://doi.org/10.1073/pnas.022324499
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    A stochastic algorithm for global optimization and for best populations: A test case of side chains in proteins

    Meir Glick, Anwar Rayan, and Amiram Goldblum

    PNAS January 22, 2002 99 (2) 703-708; https://doi.org/10.1073/pnas.022418199
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    Real-time and equilibrium ¹⁹F-NMR studies reveal the role of domain–domain interactions in the folding of the chaperone PapD

    James G. Bann, Jerome Pinkner, Scott J. Hultgren, and Carl Frieden

    PNAS January 22, 2002 99 (2) 709-714; https://doi.org/10.1073/pnas.022649599

• Cell Biology

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    Reactive oxygen generated by Nox1 triggers the angiogenic switch

    Jack L. Arbiser, John Petros, Robert Klafter, Baskaran Govindajaran, Elizabeth R. McLaughlin, Lawrence F. Brown, Cynthia Cohen, Marsha Moses, Susan Kilroy, Rebecca S. Arnold, and J. David Lambeth

    PNAS January 22, 2002 99 (2) 715-720; https://doi.org/10.1073/pnas.022630199
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    Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization

    Kiyoshi Suzuma, Noriko Takahara, Izumi Suzuma, Keiji Isshiki, Kohjiro Ueki, Michael Leitges, Lloyd Paul Aiello, and George L. King

    PNAS January 22, 2002 99 (2) 721-726; https://doi.org/10.1073/pnas.022644499
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    Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment

    Paul J. Muchowski, Ke Ning, Crislyn D'Souza-Schorey, and Stanley Fields

    PNAS January 22, 2002 99 (2) 727-732; https://doi.org/10.1073/pnas.022628699
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    Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration

    Huaiyang Chen, Ian C. Duncan, Hormozd Bozorgchami, and Su Hao Lo

    PNAS January 22, 2002 99 (2) 733-738; https://doi.org/10.1073/pnas.022518699
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    Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration

    Joan D. Ferraris, Chester K. Williams, Prita Persaud, Zheng Zhang, Ye Chen, and Maurice B. Burg

    PNAS January 22, 2002 99 (2) 739-744; https://doi.org/10.1073/pnas.241637298
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    Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome

    Minoru Funakoshi, Toru Sasaki, Takeharu Nishimoto, and Hideki Kobayashi

    PNAS January 22, 2002 99 (2) 745-750; https://doi.org/10.1073/pnas.012585199
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    Actin cable dynamics in budding yeast

    Hyeong-Cheol Yang and Liza A. Pon

    PNAS January 22, 2002 99 (2) 751-756; https://doi.org/10.1073/pnas.022462899

• Developmental Biology

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    Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome

    Benjamin P. Berman, Yutaka Nibu, Barret D. Pfeiffer, Pavel Tomancak, Susan E. Celniker, Michael Levine, Gerald M. Rubin, and Michael B. Eisen

    PNAS January 22, 2002 99 (2) 757-762; https://doi.org/10.1073/pnas.231608898

    See companion article:

    • Deciphering genetic regulatory codes: A challenge for functional genomics

      - Jan 22, 2002
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    Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo

    Michele Markstein, Peter Markstein, Vicky Markstein, and Michael S. Levine

    PNAS January 22, 2002 99 (2) 763-768; https://doi.org/10.1073/pnas.012591199

    See companion article:

    • Deciphering genetic regulatory codes: A challenge for functional genomics

      - Jan 22, 2002
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    Evolution of germ-line signals that regulate growth and aging in nematodes

    Mavji N. Patel, Christopher G. Knight, Constantina Karageorgi, and Armand M. Leroi

    PNAS January 22, 2002 99 (2) 769-774; https://doi.org/10.1073/pnas.012511099
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    APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

    Caroline Goutte, Makoto Tsunozaki, Valerie A. Hale, and James R. Priess

    PNAS January 22, 2002 99 (2) 775-779; https://doi.org/10.1073/pnas.022523499
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    Genomic structure and functional control of the Dlx3-7 bigene cluster

    Kenta Sumiyama, Steven Q. Irvine, David W. Stock, Kenneth M. Weiss, Kazuhiko Kawasaki, Nobuyoshi Shimizu, Cooduvalli S. Shashikant, Webb Miller, and Frank H. Ruddle

    PNAS January 22, 2002 99 (2) 780-785; https://doi.org/10.1073/pnas.012584999

• Ecology

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    Chemical warfare between microbes promotes biodiversity

    Tamás L. Czárán, Rolf F. Hoekstra, and Ludo Pagie

    PNAS January 22, 2002 99 (2) 786-790; https://doi.org/10.1073/pnas.012399899

    See companion article:

    • Chemical warfare from an ecological perspective

      - Jan 22, 2002
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    Golden eagles, feral pigs, and insular carnivores: How exotic species turn native predators into prey

    • From the Cover

    Gary W. Roemer, C. Josh Donlan, and Franck Courchamp

    PNAS January 22, 2002 99 (2) 791-796; https://doi.org/10.1073/pnas.012422499

    See companion article:

    • Ecological pork: Novel resources and the trophic reorganization of an ecosystem

      - Jan 22, 2002

• Evolution

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    In silico chromosome staining: Reconstruction of Giemsa bands from the whole human genome sequence

    Yoshihito Niimura and Takashi Gojobori

    PNAS January 22, 2002 99 (2) 797-802; https://doi.org/10.1073/pnas.022437999
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    Mutation rates in mammalian genomes

    Sudhir Kumar and Sankar Subramanian

    PNAS January 22, 2002 99 (2) 803-808; https://doi.org/10.1073/pnas.022629899
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    Recombinatoric exploration of novel folded structures: A heteropolymer-based model of protein evolutionary landscapes

    Yan Cui, Wing Hung Wong, Erich Bornberg-Bauer, and Hue Sun Chan

    PNAS January 22, 2002 99 (2) 809-814; https://doi.org/10.1073/pnas.022240299

• Genetics

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    Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome

    Benjamin P. Berman, Yutaka Nibu, Barret D. Pfeiffer, Pavel Tomancak, Susan E. Celniker, Michael Levine, Gerald M. Rubin, and Michael B. Eisen

    PNAS January 22, 2002 99 (2) 757-762; https://doi.org/10.1073/pnas.231608898

    See companion article:

    • Deciphering genetic regulatory codes: A challenge for functional genomics

      - Jan 22, 2002
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    Molecular analysis of mutations in DNA polymerase η in xeroderma pigmentosum-variant patients

    Bernard C. Broughton, Agnes Cordonnier, Wim J. Kleijer, Nicolaas G. J. Jaspers, Heather Fawcett, Anja Raams, Victor H. Garritsen, Anne Stary, Marie-Françoise Avril, François Boudsocq, Chikahide Masutani, Fumio Hanaoka, Robert P. Fuchs, Alain Sarasin, and Alan R. Lehmann

    PNAS January 22, 2002 99 (2) 815-820; https://doi.org/10.1073/pnas.022473899
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    Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

    David D. Kline, Ying-Jie Peng, Dominador J. Manalo, Gregg L. Semenza, and Nanduri R. Prabhakar

    PNAS January 22, 2002 99 (2) 821-826; https://doi.org/10.1073/pnas.022634199
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    Evaluation of linkage of breast cancer to the putative BRCA3 locus on chromosome 13q21 in 128 multiple case families from the Breast Cancer Linkage Consortium

    • From the Cover

    Deborah Thompson, Csilla I. Szabo, Jon Mangion, Rogier A. Oldenburg, Fabrice Odefrey, Sheila Seal, Rita Barfoot, Karin Kroeze-Jansema, Dawn Teare, Nazneen Rahman, Hélène Renard, KConFab Consortiumef, Graham Mann, John L. Hopper, Saundra S. Buys, Irene L. Andrulis, Ruby Senie, Mary B. Daly, Dee West, Elaine A. Ostrander, Ken Offit, Tamar Peretz, Ana Osorio, J. Benitez, Katherine L. Nathanson, Olga M. Sinilnikova, Edith Olàh, Yves-Jean Bignon, Pablo Ruiz, Michael D. Badzioch, Hans F. A. Vasen, Andrew P. Futreal, Catherine M. Phelan, Steven A. Narod, Henry T. Lynch, Bruce A. J. Ponder, Ros A. Eeles, Hanne Meijers-Heijboer, Dominique Stoppa-Lyonnet, Fergus J. Couch, Diana M. Eccles, D. Gareth Evans, Jenny Chang-Claude, Gilbert Lenoir, Barbara L. Weber, Peter Devilee, Douglas F. Easton, David E. Goldgar, and Michael R. Stratton

    PNAS January 22, 2002 99 (2) 827-831; https://doi.org/10.1073/pnas.012584499
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    Ku86 is essential in human somatic cells

    Gang Li, Caron Nelsen, and Eric A. Hendrickson

    PNAS January 22, 2002 99 (2) 832-837; https://doi.org/10.1073/pnas.022649699
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    Life extension in Drosophila by feeding a drug

    Hyung-Lyun Kang, Seymour Benzer, and Kyung-Tai Min

    PNAS January 22, 2002 99 (2) 838-843; https://doi.org/10.1073/pnas.022631999
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    Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15

    Eugene M. Rinchik, Donald A. Carpenter, and Dabney K. Johnson

    PNAS January 22, 2002 99 (2) 844-849; https://doi.org/10.1073/pnas.022628199
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    Physical and genetic mapping of barley (Hordeum vulgare) germin-like cDNAs

    Arnis Druka, David Kudrna, C. Gamini Kannangara, Diter von Wettstein, and Andris Kleinhofs

    PNAS January 22, 2002 99 (2) 850-855; https://doi.org/10.1073/pnas.022627999
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    Association of human aging with a functional variant of klotho

    Dan E. Arking, Alice Krebsova, Milan Macek Sr., Milan Macek Jr., Albert Arking, I. Saira Mian, Linda Fried, Ada Hamosh, Srabani Dey, Iain McIntosh, and Harry C. Dietz

    PNAS January 22, 2002 99 (2) 856-861; https://doi.org/10.1073/pnas.022484299
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    Evidence for positive selection and population structure at the human MAO-A gene

    Yoav Gilad, Shai Rosenberg, Molly Przeworski, Doron Lancet, and Karl Skorecki

    PNAS January 22, 2002 99 (2) 862-867; https://doi.org/10.1073/pnas.022614799

• Immunology

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    Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation

    Russell E. Vance, Amanda M. Jamieson, Dragana Cado, and David H. Raulet

    PNAS January 22, 2002 99 (2) 868-873; https://doi.org/10.1073/pnas.022500599
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    Grafts of supplementary thymuses injected with allogeneic pancreatic islets protect nonobese diabetic mice against diabetes

    J. Salaün, N. Simmenauer, P. Belo, A. Coutinho, and N. M. Le Douarin

    PNAS January 22, 2002 99 (2) 874-877; https://doi.org/10.1073/pnas.012597499
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    Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice

    Y. Zhang, S. F. Schlossman, R. A. Edwards, Ching-Nan Ou, J. Gu, and Mei X. Wu

    PNAS January 22, 2002 99 (2) 878-883; https://doi.org/10.1073/pnas.022326699
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    Differential role of SLP-76 domains in T cell development and function

    Lalit Kumar, Vadim Pivniouk, Miguel A. de la Fuente, Dhafer Laouini, and Raif S. Geha

    PNAS January 22, 2002 99 (2) 884-889; https://doi.org/10.1073/pnas.022619199

• Medical Sciences

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    Plasminogen activator inhibitor-1 is a major stress-regulated gene: Implications for stress-induced thrombosis in aged individuals

    Koji Yamamoto, Kyosuke Takeshita, Takayoshi Shimokawa, Hong Yi, Ken-ichi Isobe, David J. Loskutoff, and Hidehiko Saito

    PNAS January 22, 2002 99 (2) 890-895; https://doi.org/10.1073/pnas.022608799
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    Heat shock protein 90 catalyzes activation of the prekallikrein-kininogen complex in the absence of factor XII

    Kusumam Joseph, Baby G. Tholanikunnel, and Allen P. Kaplan

    PNAS January 22, 2002 99 (2) 896-900; https://doi.org/10.1073/pnas.022626899
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    Rescue of hereditary form of dilated cardiomyopathy by rAAV-mediated somatic gene therapy: Amelioration of morphological findings, sarcolemmal permeability, cardiac performances, and the prognosis of TO-2 hamsters

    Tomie Kawada, Mikio Nakazawa, Sakura Nakauchi, Ken Yamazaki, Ryoichi Shimamoto, Masashi Urabe, Jumi Nakata, Chieko Hemmi, Fujiko Masui, Toshiaki Nakajima, Jun-Ichi Suzuki, John Monahan, Hiroshi Sato, Tomoh Masaki, Keiya Ozawa, and Teruhiko Toyo-oka

    PNAS January 22, 2002 99 (2) 901-906; https://doi.org/10.1073/pnas.022641799
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    Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo

    Christopher L. Antos, Timothy A. McKinsey, Norbert Frey, William Kutschke, John McAnally, John M. Shelton, James A. Richardson, Joseph A. Hill, and Eric N. Olson

    PNAS January 22, 2002 99 (2) 907-912; https://doi.org/10.1073/pnas.231619298
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    Ca²⁺-desensitizing effect of a deletion mutation ΔK210 in cardiac troponin T that causes familial dilated cardiomyopathy

    S. Morimoto, Q.-W. Lu, K. Harada, F. Takahashi-Yanaga, R. Minakami, M. Ohta, T. Sasaguri, and I. Ohtsuki

    PNAS January 22, 2002 99 (2) 913-918; https://doi.org/10.1073/pnas.022628899
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    Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells

    Marco Prinz, Fabio Montrasio, Michael A. Klein, Petra Schwarz, Josef Priller, Bernhard Odermatt, Klaus Pfeffer, and Adriano Aguzzi

    PNAS January 22, 2002 99 (2) 919-924; https://doi.org/10.1073/pnas.022626399
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    Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer

    Shaun P. Scott, Regina Bendix, Philip Chen, Raymond Clark, Thilo Dörk, and Martin F. Lavin

    PNAS January 22, 2002 99 (2) 925-930; https://doi.org/10.1073/pnas.012329699
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    Tumor lysate-pulsed dendritic cells can elicit an effective antitumor immune response during early lymphoid recovery

    W. Asavaroengchai, Y. Kotera, and J. J. Mulé

    PNAS January 22, 2002 99 (2) 931-936; https://doi.org/10.1073/pnas.022634999
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    A peptide that binds and stabilizes p53 core domain: Chaperone strategy for rescue of oncogenic mutants

    Assaf Friedler, Lars O. Hansson, Dmitry B. Veprintsev, Stefan M. V. Freund, Thomas M. Rippin, Penka V. Nikolova, Mark R. Proctor, Stefan Rüdiger, and Alan R. Fersht

    PNAS January 22, 2002 99 (2) 937-942; https://doi.org/10.1073/pnas.241629998
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    Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)

    Donald Metcalf, Sandra Mifsud, Ladina Di Rago, Nicos A. Nicola, Douglas J. Hilton, and Warren S. Alexander

    PNAS January 22, 2002 99 (2) 943-948; https://doi.org/10.1073/pnas.022628499
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    Tumor necrosis factor-induced modulation of glyoxalase I activities through phosphorylation by PKA results in cell death and is accompanied by the formation of a specific methylglyoxal-derived AGE

    Franky Van Herreweghe, Jianqiang Mao, Frank W. R. Chaplen, Johan Grooten, Kris Gevaert, Joël Vandekerckhove, and Katia Vancompernolle

    PNAS January 22, 2002 99 (2) 949-954; https://doi.org/10.1073/pnas.012432399
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    Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function

    Dimiter G. Demirov, Akira Ono, Jan M. Orenstein, and Eric O. Freed

    PNAS January 22, 2002 99 (2) 955-960; https://doi.org/10.1073/pnas.032511899
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    Changes in subcellular distribution of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) after treatment with the LH-RH antagonist cetrorelix

    Gabor Halmos and Andrew V. Schally

    PNAS January 22, 2002 99 (2) 961-965; https://doi.org/10.1073/pnas.012598399

• Microbiology

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    A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae

    Brian J. Akerley, Eric J. Rubin, Veronica L. Novick, Kensey Amaya, Nicholas Judson, and John J. Mekalanos

    PNAS January 22, 2002 99 (2) 966-971; https://doi.org/10.1073/pnas.012602299
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    Stereotyped and specific gene expression programs in human innate immune responses to bacteria

    Jennifer C. Boldrick, Ash A. Alizadeh, Maximilian Diehn, Sandrine Dudoit, Chih Long Liu, Christopher E. Belcher, David Botstein, Louis M. Staudt, Patrick O. Brown, and David A. Relman

    PNAS January 22, 2002 99 (2) 972-977; https://doi.org/10.1073/pnas.231625398
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    Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice

    Lawrence T. Feldman, Aaron R. Ellison, Cynthia C. Voytek, Li Yang, Philip Krause, and Todd P. Margolis

    PNAS January 22, 2002 99 (2) 978-983; https://doi.org/10.1073/pnas.022301899
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    Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum

    Sorel T. Fitz-Gibbon, Heidi Ladner, Ung-Jin Kim, Karl O. Stetter, Melvin I. Simon, and Jeffrey H. Miller

    PNAS January 22, 2002 99 (2) 984-989; https://doi.org/10.1073/pnas.241636498
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    Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine

    Ritu Banerjee, Jun Liu, Wandy Beatty, Lorraine Pelosof, Michael Klemba, and Daniel E. Goldberg

    PNAS January 22, 2002 99 (2) 990-995; https://doi.org/10.1073/pnas.022630099
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    Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater

    Tohru Shimizu, Kaori Ohtani, Hideki Hirakawa, Kenshiro Ohshima, Atsushi Yamashita, Tadayoshi Shiba, Naotake Ogasawara, Masahira Hattori, Satoru Kuhara, and Hideo Hayashi

    PNAS January 22, 2002 99 (2) 996-1001; https://doi.org/10.1073/pnas.022493799

• Neurobiology

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    Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity

    Ali Khoshnan, Jan Ko, and Paul H. Patterson

    PNAS January 22, 2002 99 (2) 1002-1007; https://doi.org/10.1073/pnas.022631799
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    Role of a locus control region in the mutually exclusive expression of human red and green cone pigment genes

    Philip M. Smallwood, Yanshu Wang, and Jeremy Nathans

    PNAS January 22, 2002 99 (2) 1008-1011; https://doi.org/10.1073/pnas.022629799
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    Synaptophysin regulates activity-dependent synapse formation in cultured hippocampal neurons

    Leila Tarsa and Yukiko Goda

    PNAS January 22, 2002 99 (2) 1012-1016; https://doi.org/10.1073/pnas.022575999
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    Experience-dependent changes in cerebellar contributions to motor sequence learning

    Julien Doyon, Allen W. Song, Avi Karni, François Lalonde, Michelle M. Adams, and Leslie G. Ungerleider

    PNAS January 22, 2002 99 (2) 1017-1022; https://doi.org/10.1073/pnas.022615199
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    Costimulation of N-methyl-d-aspartate and muscarinic neuronal receptors modulates gap junctional communication in striatal astrocytes

    N. Rouach, M. Tencé, J. Glowinski, and C. Giaume

    PNAS January 22, 2002 99 (2) 1023-1028; https://doi.org/10.1073/pnas.022257499
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    The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline

    Luc Jasmin, Duc Tien, David Weinshenker, Richard D. Palmiter, Paul G. Green, Gabriella Janni, and Peter T. Ohara

    PNAS January 22, 2002 99 (2) 1029-1034; https://doi.org/10.1073/pnas.012598599

    See companion article:

    • Substance P, opioid, and catecholamine systems in the mouse central nervous system (CNS)

      - Jan 22, 2002
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    Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain

    Mats H. Holmqvist, Jie Cao, Ricardo Hernandez-Pineda, Michael D. Jacobson, Karen I. Carroll, M. Amy Sung, Maria Betty, Pei Ge, Kevin J. Gilbride, Melissa E. Brown, Mark E. Jurman, Deborah Lawson, Inmaculada Silos-Santiago, Yu Xie, Manuel Covarrubias, Kenneth J. Rhodes, Peter S. Distefano, and W. Frank An

    PNAS January 22, 2002 99 (2) 1035-1040; https://doi.org/10.1073/pnas.022509299
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    Experience-dependent plasticity without long-term depression by type 2 metabotropic glutamate receptors in developing visual cortex

    John J. Renger, Kenichi N. Hartman, Yoshiko Tsuchimoto, Mineto Yokoi, Shigetada Nakanishi, and Takao K. Hensch

    PNAS January 22, 2002 99 (2) 1041-1046; https://doi.org/10.1073/pnas.022618799

• Pharmacology

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    Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin

    Todd A. Huffman, Isabelle Mothe-Satney, and John C. Lawrence Jr.

    PNAS January 22, 2002 99 (2) 1047-1052; https://doi.org/10.1073/pnas.022634399

• Physiology

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    Anti-inflammatory role in septic shock of pituitary adenylate cyclase-activating polypeptide receptor

    Carmen Martinez, Catalina Abad, Mario Delgado, Alicia Arranz, Maria G. Juarranz, Nieves Rodriguez-Henche, Philippe Brabet, Javier Leceta, and Rosa P. Gomariz

    PNAS January 22, 2002 99 (2) 1053-1058; https://doi.org/10.1073/pnas.012367999
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    Decreased pulmonary vascular permeability in aquaporin-1-null humans

    Landon S. King, Søren Nielsen, Peter Agre, and Robert H. Brown

    PNAS January 22, 2002 99 (2) 1059-1063; https://doi.org/10.1073/pnas.022626499

• Plant Biology

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    The tomato Blind gene encodes a MYB transcription factor that controls the formation of lateral meristems

    Gregor Schmitz, Edith Tillmann, Filomena Carriero, Carola Fiore, Francesco Cellini, and Klaus Theres

    PNAS January 22, 2002 99 (2) 1064-1069; https://doi.org/10.1073/pnas.022516199
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    Directed molecular evolution of ADP-glucose pyrophosphorylase

    Peter R. Salamone, I. Halil Kavakli, Casey J. Slattery, and Thomas W. Okita

    PNAS January 22, 2002 99 (2) 1070-1075; https://doi.org/10.1073/pnas.012603799
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    Suppressors of transcriptional transgenic silencing in Chlamydomonas are sensitive to DNA-damaging agents and reactivate transposable elements

    • From the Cover

    Byeong-ryool Jeong, Dancia Wu-Scharf, Chaomei Zhang, and Heriberto Cerutti

    PNAS January 22, 2002 99 (2) 1076-1081; https://doi.org/10.1073/pnas.022392999
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    Recombination rates between adjacent genic and retrotransposon regions in maize vary by 2 orders of magnitude

    Huihua Fu, Zhenwei Zheng, and Hugo K. Dooner

    PNAS January 22, 2002 99 (2) 1082-1087; https://doi.org/10.1073/pnas.022635499

    See companion article:

    • Finding the crosswalks on DNA

      - Apr 30, 2002
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    Impact of folivory on photosynthesis is greater than the sum of its holes

    A. R. Zangerl, J. G. Hamilton, T. J. Miller, A. R. Crofts, K. Oxborough, M. R. Berenbaum, and E. H. de Lucia

    PNAS January 22, 2002 99 (2) 1088-1091; https://doi.org/10.1073/pnas.022647099
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    Evaluation of transgenic tomato plants expressing an additional phytoene synthase in a fruit-specific manner

    Paul D. Fraser, Susanne Romer, Cathie A. Shipton, Philippa B. Mills, Joy W. Kiano, Norihiko Misawa, Rachel G. Drake, Wolfgang Schuch, and Peter M. Bramley

    PNAS January 22, 2002 99 (2) 1092-1097; https://doi.org/10.1073/pnas.241374598