Table of Contents

Biological Sciences

• Biochemistry

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    An approach to membrane protein structure without crystals

    Paul L. Sorgen, Yonglin Hu, Lan Guan, H. Ronald Kaback, and Mark E. Girvin

    PNAS October 29, 2002 99 (22) 14037-14040; https://doi.org/10.1073/pnas.182552199
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    Crystal structure of the DNA-binding domain from Ndt80, a transcriptional activator required for meiosis in yeast

    Sherwin P. Montano, Marie L. Coté, Ian Fingerman, Michael Pierce, Andrew K. Vershon, and Millie M. Georgiadis

    PNAS October 29, 2002 99 (22) 14041-14046; https://doi.org/10.1073/pnas.222312199
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    A nucleolar TAR decoy inhibitor of HIV-1 replication

    Alessandro Michienzi, Shirley Li, John A. Zaia, and John J. Rossi

    PNAS October 29, 2002 99 (22) 14047-14052; https://doi.org/10.1073/pnas.212229599
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    Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide

    Logan W. Donaldson, Gerald Gish, Tony Pawson, Lewis E. Kay, and Julie D. Forman-Kay

    PNAS October 29, 2002 99 (22) 14053-14058; https://doi.org/10.1073/pnas.212518799
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    Three-dimensional model of the human platelet integrin α_IIbβ₃ based on electron cryomicroscopy and x-ray crystallography

    Brian D. Adair and Mark Yeager

    PNAS October 29, 2002 99 (22) 14059-14064; https://doi.org/10.1073/pnas.212498199
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    Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor

    Arienne N. Poux, Marek Cebrat, Cheol M. Kim, Philip A. Cole, and Ronen Marmorstein

    PNAS October 29, 2002 99 (22) 14065-14070; https://doi.org/10.1073/pnas.222373899
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    Small molecule modulation of Smoothened activity

    James K. Chen, Jussi Taipale, Keith E. Young, Tapan Maiti, and Philip A. Beachy

    PNAS October 29, 2002 99 (22) 14071-14076; https://doi.org/10.1073/pnas.182542899
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    Promiscuity in ligand-binding: The three-dimensional structure of a Piromyces carbohydrate-binding module, CBM29-2, in complex with cello- and mannohexaose

    Simon J. Charnock, David N. Bolam, Didier Nurizzo, Lóránd Szabó, Vincent A. McKie, Harry J. Gilbert, and Gideon J. Davies

    PNAS October 29, 2002 99 (22) 14077-14082; https://doi.org/10.1073/pnas.212516199
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    Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases

    Dirk Schwarzer, Henning D. Mootz, Uwe Linne, and Mohamed A. Marahiel

    PNAS October 29, 2002 99 (22) 14083-14088; https://doi.org/10.1073/pnas.212382199
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    Does RNA polymerase help drive chromosome segregation in bacteria?

    Jonathan Dworkin and Richard Losick

    PNAS October 29, 2002 99 (22) 14089-14094; https://doi.org/10.1073/pnas.182539899
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    φ value analysis of heterogeneity in pathways of allosteric transitions: Evidence for parallel pathways of ATP-induced conformational changes in a GroEL ring

    Amnon Horovitz, Amnon Amir, Oded Danziger, and Galit Kafri

    PNAS October 29, 2002 99 (22) 14095-14097; https://doi.org/10.1073/pnas.222303299
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    Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer

    Tohru Yamada, Masatoshi Goto, Vasu Punj, Olga Zaborina, Mei Ling Chen, Kazuhide Kimbara, Dibyen Majumdar, Elizabeth Cunningham, Tapas K. Das Gupta, and Ananda M. Chakrabarty

    PNAS October 29, 2002 99 (22) 14098-14103; https://doi.org/10.1073/pnas.222539699
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    Tubulin is the endogenous inhibitor of the glyceraldehyde 3-phosphate dehydrogenase isoform that catalyzes membrane fusion: Implications for the coordinated regulation of glycolysis and membrane fusion

    Paul E. Glaser, Xianlin Han, and Richard W. Gross

    PNAS October 29, 2002 99 (22) 14104-14109; https://doi.org/10.1073/pnas.222542999

• Biophysics

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    Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain

    Fangyong Du, Federico Navarro-Garcia, Zanxian Xia, Takafumi Tasaki, and Alexander Varshavsky

    PNAS October 29, 2002 99 (22) 14110-14115; https://doi.org/10.1073/pnas.172527399
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    A simple physical model for binding energy hot spots in protein–protein complexes

    Tanja Kortemme and David Baker

    PNAS October 29, 2002 99 (22) 14116-14121; https://doi.org/10.1073/pnas.202485799
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    On the simulation of protein folding by short time scale molecular dynamics and distributed computing

    Alan R. Fersht

    PNAS October 29, 2002 99 (22) 14122-14125; https://doi.org/10.1073/pnas.182542699
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    Stabilities and conformations of Alzheimer's β-amyloid peptide oligomers (Aβ_16–22, Aβ_16–35, and Aβ_10–35): Sequence effects

    Buyong Ma and Ruth Nussinov

    PNAS October 29, 2002 99 (22) 14126-14131; https://doi.org/10.1073/pnas.212206899
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    Expanding protein universe and its origin from the biological Big Bang

    Nikolay V. Dokholyan, Boris Shakhnovich, and Eugene I. Shakhnovich

    PNAS October 29, 2002 99 (22) 14132-14136; https://doi.org/10.1073/pnas.202497999
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    Common features in structures and sequences of sandwich-like proteins

    Alexander E. Kister, Alexei V. Finkelstein, and Israel M. Gelfand

    PNAS October 29, 2002 99 (22) 14137-14141; https://doi.org/10.1073/pnas.212511499
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    Electronic detection of DNA by its intrinsic molecular charge

    Jürgen Fritz, Emily B. Cooper, Suzanne Gaudet, Peter K. Sorger, and Scott R. Manalis

    PNAS October 29, 2002 99 (22) 14142-14146; https://doi.org/10.1073/pnas.232276699
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    Molecular topography imaging by intermembrane fluorescence resonance energy transfer

    Amy P. Wong and Jay T. Groves

    PNAS October 29, 2002 99 (22) 14147-14152; https://doi.org/10.1073/pnas.212392599
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    Identification of macromolecular complexes in cryoelectron tomograms of phantom cells

    Achilleas S. Frangakis, Jochen Böhm, Friedrich Förster, Stephan Nickell, Daniela Nicastro, Dieter Typke, Reiner Hegerl, and Wolfgang Baumeister

    PNAS October 29, 2002 99 (22) 14153-14158; https://doi.org/10.1073/pnas.172520299
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    Role of the lever arm in the processive stepping of myosin V

    Thomas J. Purcell, Carl Morris, James A. Spudich, and H. Lee Sweeney

    PNAS October 29, 2002 99 (22) 14159-14164; https://doi.org/10.1073/pnas.182539599
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    Effect of polyethylene glycol on the liquid–liquid phase transition in aqueous protein solutions

    Onofrio Annunziata, Neer Asherie, Aleksey Lomakin, Jayanti Pande, Olutayo Ogun, and George B. Benedek

    PNAS October 29, 2002 99 (22) 14165-14170; https://doi.org/10.1073/pnas.212507199
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    Measurement of microsecond dynamic motion in the intestinal fatty acid binding protein by using fluorescence correlation spectroscopy

    Krishnananda Chattopadhyay, Saveez Saffarian, Elliot L. Elson, and Carl Frieden

    PNAS October 29, 2002 99 (22) 14171-14176; https://doi.org/10.1073/pnas.172524899

• Cell Biology

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    Glucose is toxic to glycosome-deficient trypanosomes

    Tetsuya Furuya, Peter Kessler, Armando Jardim, Achim Schnaufer, Christopher Crudder, and Marilyn Parsons

    PNAS October 29, 2002 99 (22) 14177-14182; https://doi.org/10.1073/pnas.222454899
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    Cell surface polarization during yeast mating

    Michel Bagnat and Kai Simons

    PNAS October 29, 2002 99 (22) 14183-14188; https://doi.org/10.1073/pnas.172517799
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    JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors

    Clement M. Lee, Djamila Onésime, C. Damodara Reddy, N. Dhanasekaran, and E. Premkumar Reddy

    PNAS October 29, 2002 99 (22) 14189-14194; https://doi.org/10.1073/pnas.232310199
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    Karyopherin β2B participates in mRNA export from the nucleus

    Monee K. Shamsher, Jonathan Ploski, and Aurelian Radu

    PNAS October 29, 2002 99 (22) 14195-14199; https://doi.org/10.1073/pnas.212518199
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    RB activation defect in tumor cell lines

    Cristina Broceño, Scott Wilkie, and Sibylle Mittnacht

    PNAS October 29, 2002 99 (22) 14200-14205; https://doi.org/10.1073/pnas.212519499
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    Inositol pyrophosphates regulate endocytic trafficking

    Adolfo Saiardi, Catherine Sciambi, J. Michael McCaffery, Beverly Wendland, and Solomon H. Snyder

    PNAS October 29, 2002 99 (22) 14206-14211; https://doi.org/10.1073/pnas.212527899
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    Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-κB-repressing factor (NRF) in basal repression of the hiNOS gene

    Xuesheng Feng, Zhong Guo, Mahtab Nourbakhsh, Hansjorg Hauser, Ray Ganster, Lifang Shao, and David A. Geller

    PNAS October 29, 2002 99 (22) 14212-14217; https://doi.org/10.1073/pnas.212306199

• Developmental Biology

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    The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development

    Ho-Yon Hwang and H. Robert Horvitz

    PNAS October 29, 2002 99 (22) 14218-14223; https://doi.org/10.1073/pnas.172522199
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    The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated

    Ho-Yon Hwang and H. Robert Horvitz

    PNAS October 29, 2002 99 (22) 14224-14229; https://doi.org/10.1073/pnas.172522499
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    Efficient production by sperm-mediated gene transfer of human decay accelerating factor (hDAF) transgenic pigs for xenotransplantation

    Marialuisa Lavitrano, Maria Laura Bacci, Monica Forni, Davide Lazzereschi, Carla Di Stefano, Daniela Fioretti, Paola Giancotti, Gabriella Marfé, Loredana Pucci, Luigina Renzi, Hongjun Wang, Antonella Stoppacciaro, Giorgio Stassi, Massimo Sargiacomo, Paola Sinibaldi, Valeria Turchi, Roberto Giovannoni, Giacinto Della Casa, Eraldo Seren, and Giancarlo Rossi

    PNAS October 29, 2002 99 (22) 14230-14235; https://doi.org/10.1073/pnas.222550299
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    Tissue-specific RNA interference in postimplantation mouse embryos with endoribonuclease-prepared short interfering RNA

    Federico Calegari, Wulf Haubensak, Dun Yang, Wieland B. Huttner, and Frank Buchholz

    PNAS October 29, 2002 99 (22) 14236-14240; https://doi.org/10.1073/pnas.192559699
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    The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium

    Cathrin Brisken, Merav Socolovsky, Harvey F. Lodish, and Robert Weinberg

    PNAS October 29, 2002 99 (22) 14241-14245; https://doi.org/10.1073/pnas.222549599

• Ecology

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    Bioactive alkaloids of frog skin: Combinatorial bioprospecting reveals that pumiliotoxins have an arthropod source

    John W. Daly, Tetsuo Kaneko, Jason Wilham, H. Martin Garraffo, Thomas F. Spande, Alex Espinosa, and Maureen A. Donnelly

    PNAS October 29, 2002 99 (22) 13996-14001; https://doi.org/10.1073/pnas.222551599
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    A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

    Jörn Piel

    PNAS October 29, 2002 99 (22) 14002-14007; https://doi.org/10.1073/pnas.222481399
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    Interactions of climate change with biological invasions and land use in the Hawaiian Islands: Modeling the fate of endemic birds using a geographic information system

    Tracy L. Benning, Dennis LaPointe, Carter T. Atkinson, and Peter M. Vitousek

    PNAS October 29, 2002 99 (22) 14246-14249; https://doi.org/10.1073/pnas.162372399
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    Genomic analysis of uncultured marine viral communities

    Mya Breitbart, Peter Salamon, Bjarne Andresen, Joseph M. Mahaffy, Anca M. Segall, David Mead, Farooq Azam, and Forest Rohwer

    PNAS October 29, 2002 99 (22) 14250-14255; https://doi.org/10.1073/pnas.202488399
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    Carbon emissions from tropical deforestation and regrowth based on satellite observations for the 1980s and 1990s

    Ruth S. DeFries, Richard A. Houghton, Matthew C. Hansen, Christopher B. Field, David Skole, and John Townshend

    PNAS October 29, 2002 99 (22) 14256-14261; https://doi.org/10.1073/pnas.182560099

• Evolution

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    Expanding protein universe and its origin from the biological Big Bang

    Nikolay V. Dokholyan, Boris Shakhnovich, and Eugene I. Shakhnovich

    PNAS October 29, 2002 99 (22) 14132-14136; https://doi.org/10.1073/pnas.202497999
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    Modularity, individuality, and evo-devo in butterfly wings

    Patrícia Beldade, Kees Koops, and Paul M. Brakefield

    PNAS October 29, 2002 99 (22) 14262-14267; https://doi.org/10.1073/pnas.222236199
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    Solving the freeloaders paradox: Genetic associations and frequency-dependent selection in the evolution of cooperation among nonrelatives

    Leticia Avilés

    PNAS October 29, 2002 99 (22) 14268-14273; https://doi.org/10.1073/pnas.212408299
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    Experimental evolution of learning ability in fruit flies

    Frederic Mery and Tadeusz J. Kawecki

    PNAS October 29, 2002 99 (22) 14274-14279; https://doi.org/10.1073/pnas.222371199
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    Genome fragment of Wolbachia endosymbiont transferred to X chromosome of host insect

    Natsuko Kondo, Naruo Nikoh, Nobuyuki Ijichi, Masakazu Shimada, and Takema Fukatsu

    PNAS October 29, 2002 99 (22) 14280-14285; https://doi.org/10.1073/pnas.222228199
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    A test of evolutionary theories of aging

    Kimberly A. Hughes, Julie A. Alipaz, Jenny M. Drnevich, and Rose M. Reynolds

    PNAS October 29, 2002 99 (22) 14286-14291; https://doi.org/10.1073/pnas.222326199
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    Molecular evidence of HIV-1 transmission in a criminal case

    Michael L. Metzker, David P. Mindell, Xiao-Mei Liu, Roger G. Ptak, Richard A. Gibbs, and David M. Hillis

    PNAS October 29, 2002 99 (22) 14292-14297; https://doi.org/10.1073/pnas.222522599

• Genetics

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    Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals

    • From the Cover

    Seiko Ishida, Jaekwon Lee, Dennis J. Thiele, and Ira Herskowitz

    PNAS October 29, 2002 99 (22) 14298-14302; https://doi.org/10.1073/pnas.162491399

    See companion article:

    • A copper connection to the uptake of platinum anticancer drugs

      - Oct 21, 2002
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    The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossification

    Liesbeth Van Wesenbeeck, Paul R. Odgren, Carole A. MacKay, Marina D'Angelo, Fayez F. Safadi, Steven N. Popoff, Wim Van Hul, and Sandy C. Marks Jr.

    PNAS October 29, 2002 99 (22) 14303-14308; https://doi.org/10.1073/pnas.202332999
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    Hematopoietic-specific activators establish an overlapping pattern of histone acetylation and methylation within a mammalian chromatin domain

    Carol M. Kiekhaefer, Jeffrey A. Grass, Kirby D. Johnson, Meghan E. Boyer, and Emery H. Bresnick

    PNAS October 29, 2002 99 (22) 14309-14314; https://doi.org/10.1073/pnas.212389499
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    Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy

    Felix Knauf, Blanka Rogina, Zhirong Jiang, Peter S. Aronson, and Stephen L. Helfand

    PNAS October 29, 2002 99 (22) 14315-14319; https://doi.org/10.1073/pnas.222531899
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    Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development

    Lan Chen, Daniel Segal, Neil A. Hukriede, Alexandre V. Podtelejnikov, Dashzeveg Bayarsaihan, James A. Kennison, Vasily V. Ogryzko, Igor B. Dawid, and Heiner Westphal

    PNAS October 29, 2002 99 (22) 14320-14325; https://doi.org/10.1073/pnas.212532399
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    A computational/functional genomics approach for the enrichment of the retinal transcriptome and the identification of positional candidate retinopathy genes

    Nicholas Katsanis, Kim C. Worley, Guillermo Gonzalez, Stephen J. Ansley, and James R. Lupski

    PNAS October 29, 2002 99 (22) 14326-14331; https://doi.org/10.1073/pnas.222409099
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    Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin

    Christopher D. Shaffer, Gena E. Stephens, Brandi A. Thompson, Levi Funches, John A. Bernat, Carolyn A. Craig, and Sarah C. R. Elgin

    PNAS October 29, 2002 99 (22) 14332-14337; https://doi.org/10.1073/pnas.212458899

• Immunology

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    Protection of the intestinal mucosa by intraepithelial γδ T cells

    Yaping Chen, Kevin Chou, Elaine Fuchs, Wendy L. Havran, and Richard Boismenu

    PNAS October 29, 2002 99 (22) 14338-14343; https://doi.org/10.1073/pnas.212290499
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    PI31 is a modulator of proteasome formation and antigen processing

    Dietmar M. W. Zaiss, Sybille Standera, Peter-M. Kloetzel, and Alice J. A. M. Sijts

    PNAS October 29, 2002 99 (22) 14344-14349; https://doi.org/10.1073/pnas.212257299
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    Isolation and characterization of lymphocyte-like cells from a lamprey

    Werner E. Mayer, Tatiana Uinuk-ool, Herbert Tichy, Lanier A. Gartland, Jan Klein, and Max D. Cooper

    PNAS October 29, 2002 99 (22) 14350-14355; https://doi.org/10.1073/pnas.212527499
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    Lamprey lymphocyte-like cells express homologs of genes involved in immunologically relevant activities of mammalian lymphocytes

    Tatiana Uinuk-ool, Werner E. Mayer, Akie Sato, Roman Dongak, Max D. Cooper, and Jan Klein

    PNAS October 29, 2002 99 (22) 14356-14361; https://doi.org/10.1073/pnas.212527699
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    Glycosaminoglycans are a potential cause of rheumatoid arthritis

    Julia Y. Wang and Michael H. Roehrl

    PNAS October 29, 2002 99 (22) 14362-14367; https://doi.org/10.1073/pnas.222536599
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    Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph node

    Laura Mandik-Nayak, Brian T. Wipke, Fei F. Shih, Emil R. Unanue, and Paul M. Allen

    PNAS October 29, 2002 99 (22) 14368-14373; https://doi.org/10.1073/pnas.182549099

• Medical Sciences

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    Molecular sequelae of proteasome inhibition in human multiple myeloma cells

    Nicholas Mitsiades, Constantine S. Mitsiades, Vassiliki Poulaki, Dharminder Chauhan, Galinos Fanourakis, Xuesong Gu, Charles Bailey, Marie Joseph, Towia A. Libermann, Steven P. Treon, Nikhil C. Munshi, Paul G. Richardson, Teru Hideshima, and Kenneth C. Anderson

    PNAS October 29, 2002 99 (22) 14374-14379; https://doi.org/10.1073/pnas.202445099
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    Permanent and panerythroid correction of murine β thalassemia by multiple lentiviral integration in hematopoietic stem cells

    Suzan Imren, Emmanuel Payen, Karen A. Westerman, Robert Pawliuk, Mary E. Fabry, Connie J. Eaves, Benjamin Cavilla, Louis D. Wadsworth, Yves Beuzard, Eric E. Bouhassira, Robert Russell, Irving M. London, Ronald L. Nagel, Philippe Leboulch, and R. Keith Humphries

    PNAS October 29, 2002 99 (22) 14380-14385; https://doi.org/10.1073/pnas.212507099
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    Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways

    Cheryl Twu, Nancy Q. Liu, Waldemar Popik, Michael Bukrinsky, James Sayre, Jaclyn Roberts, Shammas Rania, Vishnu Bramhandam, Kenneth P. Roos, W. Robb MacLellan, and Milan Fiala

    PNAS October 29, 2002 99 (22) 14386-14391; https://doi.org/10.1073/pnas.212327899
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    Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma

    Katrina K. Hoyer, Samuel W. French, Devin E. Turner, Mai T. N. Nguyen, Mathilde Renard, Cindy S. Malone, Sonja Knoetig, Chen-Feng Qi, Thomas T. Su, Hilde Cheroutre, Randolph Wall, David J. Rawlings, Herbert C. Morse III, and Michael A. Teitell

    PNAS October 29, 2002 99 (22) 14392-14397; https://doi.org/10.1073/pnas.212410199
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    Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells

    Juran Kato-Stankiewicz, Irina Hakimi, Gang Zhi, Jie Zhang, Ilya Serebriiskii, Lea Guo, Hironori Edamatsu, Hiroshi Koide, Sanjay Menon, Robert Eckl, Sukumar Sakamuri, Yingchun Lu, Quin-Zene Chen, Seema Agarwal, William R. Baumbach, Erica A. Golemis, Fuyuhiko Tamanoi, and Vladimir Khazak

    PNAS October 29, 2002 99 (22) 14398-14403; https://doi.org/10.1073/pnas.222222699
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    Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression

    Hisamitsu Ide, David B. Seligson, Sanaz Memarzadeh, Li Xin, Steve Horvath, Purnima Dubey, Maryann B. Flick, Barry M. Kacinski, Aarno Palotie, and Owen N. Witte

    PNAS October 29, 2002 99 (22) 14404-14409; https://doi.org/10.1073/pnas.222537099
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    Structure of HIV-2 reverse transcriptase at 2.35-Å resolution and the mechanism of resistance to non-nucleoside inhibitors

    J. Ren, L. E. Bird, P. P. Chamberlain, G. B. Stewart-Jones, D. I. Stuart, and D. K. Stammers

    PNAS October 29, 2002 99 (22) 14410-14415; https://doi.org/10.1073/pnas.222366699
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    Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees

    Jens Bukh, Thomas Pietschmann, Volker Lohmann, Nicole Krieger, Kristina Faulk, Ronald E. Engle, Sugantha Govindarajan, Max Shapiro, Marisa St. Claire, and Ralf Bartenschlager

    PNAS October 29, 2002 99 (22) 14416-14421; https://doi.org/10.1073/pnas.212532699

• Microbiology

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    The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract

    Mark A. Schell, Maria Karmirantzou, Berend Snel, David Vilanova, Bernard Berger, Gabriella Pessi, Marie-Camille Zwahlen, Frank Desiere, Peer Bork, Michele Delley, R. David Pridmore, and Fabrizio Arigoni

    PNAS October 29, 2002 99 (22) 14422-14427; https://doi.org/10.1073/pnas.212527599
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    Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

    Hideaki Higashi, Ryouhei Tsutsumi, Akiko Fujita, Shiho Yamazaki, Masahiro Asaka, Takeshi Azuma, and Masanori Hatakeyama

    PNAS October 29, 2002 99 (22) 14428-14433; https://doi.org/10.1073/pnas.222375399
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    Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen

    Dragana Ajdić, William M. McShan, Robert E. McLaughlin, Gorana Savić, Jin Chang, Matthew B. Carson, Charles Primeaux, Runying Tian, Steve Kenton, Honggui Jia, Shaoping Lin, Yudong Qian, Shuling Li, Hua Zhu, Fares Najar, Hongshing Lai, Jim White, Bruce A. Roe, and Joseph J. Ferretti

    PNAS October 29, 2002 99 (22) 14434-14439; https://doi.org/10.1073/pnas.172501299
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    A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export

    Dirk Daelemans, Elena Afonina, Jakob Nilsson, Gudrun Werner, Jørgen Kjems, Erik De Clercq, George N. Pavlakis, and Anne-Mieke Vandamme

    PNAS October 29, 2002 99 (22) 14440-14445; https://doi.org/10.1073/pnas.212285299
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    Bradyoxetin, a unique chemical signal involved in symbiotic gene regulation

    John Loh, Russell W. Carlson, William S. York, and Gary Stacey

    PNAS October 29, 2002 99 (22) 14446-14451; https://doi.org/10.1073/pnas.222336799

• Neuroscience

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    Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

    Richard Rozmahel, Howard T. J. Mount, Fusheng Chen, Van Nguyen, Jean Huang, Serap Erdebil, Jennifer Liauw, Gang Yu, Hiroshe Hasegawa, YongJun Gu, You-Qiang Song, Stephen D. Schmidt, Ralph A. Nixon, Paul M. Mathews, Catherine Bergeron, Paul Fraser, David Westaway, and Peter St George-Hyslop

    PNAS October 29, 2002 99 (22) 14452-14457; https://doi.org/10.1073/pnas.222413999
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    Multiple spatiotemporal modes of actin reorganization by NMDA receptors and voltage-gated Ca²⁺ channels

    Tomoyuki Furuyashiki, Yoshiki Arakawa, Sayaka Takemoto-Kimura, Haruhiko Bito, and Shuh Narumiya

    PNAS October 29, 2002 99 (22) 14458-14463; https://doi.org/10.1073/pnas.212148999
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    A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones

    Yun Wang, Xinran Liu, Thomas Biederer, and Thomas C. Südhof

    PNAS October 29, 2002 99 (22) 14464-14469; https://doi.org/10.1073/pnas.182532999
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    Internalization and recycling of 5-HT_2A receptors activated by serotonin and protein kinase C-mediated mechanisms

    Samarjit Bhattacharyya, Sapna Puri, Ricardo Miledi, and Mitradas M. Panicker

    PNAS October 29, 2002 99 (22) 14470-14475; https://doi.org/10.1073/pnas.212517999
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    Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton

    Oleg Shupliakov, Ona Bloom, Jenny S. Gustafsson, Ole Kjaerulff, Peter Löw, Nikolay Tomilin, Vincent A. Pieribone, Paul Greengard, and Lennart Brodin

    PNAS October 29, 2002 99 (22) 14476-14481; https://doi.org/10.1073/pnas.212381799
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    A probabilistic explanation of brightness scaling

    Surajit Nundy and Dale Purves

    PNAS October 29, 2002 99 (22) 14482-14487; https://doi.org/10.1073/pnas.172520399
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    The identification of vesicular glutamate transporter 3 suggests novel modes of signaling by glutamate

    Robert T. Fremeau Jr., Jonathon Burman, Tayyaba Qureshi, Cindy H. Tran, John Proctor, Juliette Johnson, Hui Zhang, David Sulzer, David R. Copenhagen, Jon Storm-Mathisen, Richard J. Reimer, Farrukh A. Chaudhry, and Robert H. Edwards

    PNAS October 29, 2002 99 (22) 14488-14493; https://doi.org/10.1073/pnas.222546799
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    Two different inward rectifier K⁺ channels are effectors for transmitter-induced slow excitation in brain neurons

    D. Bajic, M. Koike, A. M. Albsoul-Younes, S. Nakajima, and Y. Nakajima

    PNAS October 29, 2002 99 (22) 14494-14499; https://doi.org/10.1073/pnas.222379999
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    Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice

    Richard Wing-Chuen Wong, Mitsutoshi Setou, Junlin Teng, Yosuke Takei, and Nobutaka Hirokawa

    PNAS October 29, 2002 99 (22) 14500-14505; https://doi.org/10.1073/pnas.222371099
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    Neural stem cell heterogeneity demonstrated by molecular phenotyping of clonal neurospheres

    Oleg N. Suslov, Valery G. Kukekov, Tatyana N. Ignatova, and Dennis A. Steindler

    PNAS October 29, 2002 99 (22) 14506-14511; https://doi.org/10.1073/pnas.212525299
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    Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons

    Gaël Daoudal, Yasuhiro Hanada, and Dominique Debanne

    PNAS October 29, 2002 99 (22) 14512-14517; https://doi.org/10.1073/pnas.222546399
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    The role of ipsilateral premotor cortex in hand movement after stroke

    Heidi Johansen-Berg, Matthew F. S. Rushworth, Marko D. Bogdanovic, Udo Kischka, Sunil Wimalaratna, and Paul M. Matthews

    PNAS October 29, 2002 99 (22) 14518-14523; https://doi.org/10.1073/pnas.222536799
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    Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP

    • From the Cover

    William Dauer, Nikolai Kholodilov, Miquel Vila, Anne-Cecile Trillat, Rose Goodchild, Kristin E. Larsen, Roland Staal, Kim Tieu, Yvonne Schmitz, Chao Annie Yuan, Marcelo Rocha, Vernice Jackson-Lewis, Steven Hersch, David Sulzer, Serge Przedborski, Robert Burke, and Rene Hen

    PNAS October 29, 2002 99 (22) 14524-14529; https://doi.org/10.1073/pnas.172514599

    See companion article:

    • Etiology of Parkinson's disease: Genetics and environment revisited

      - Oct 21, 2002
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    Control of lactotrop proliferation by dopamine: Essential role of signaling through D2 receptors and ERKs

    Ciro Iaccarino, Tarek A. Samad, Carole Mathis, Henri Kercret, Roberto Picetti, and Emiliana Borrelli

    PNAS October 29, 2002 99 (22) 14530-14535; https://doi.org/10.1073/pnas.222319599
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    A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses

    Kazuhiko Yamaguchi, Miki Tanaka, Akira Mizoguchi, Yoshihiro Hirata, Hiroyoshi Ishizaki, Kumi Kaneko, Jun Miyoshi, and Yoshimi Takai

    PNAS October 29, 2002 99 (22) 14536-14541; https://doi.org/10.1073/pnas.212511399
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    Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-d-aspartate (NMDA) receptor coagonist d-serine

    Joari de Miranda, Rogerio Panizzutti, Veronika N. Foltyn, and Herman Wolosker

    PNAS October 29, 2002 99 (22) 14542-14547; https://doi.org/10.1073/pnas.222421299

• Pharmacology

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    Selenomethionine regulation of p53 by a ref1-dependent redox mechanism

    • From the Cover

    Young R. Seo, Mark R. Kelley, and Martin L. Smith

    PNAS October 29, 2002 99 (22) 14548-14553; https://doi.org/10.1073/pnas.212319799

    See companion article:

    • New careers for antioxidants

      - Oct 21, 2002
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    A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants

    Mark G. Hearn, Yong Ren, Edward W. McBride, Isabelle Reveillaud, Martin Beinborn, and Alan S. Kopin

    PNAS October 29, 2002 99 (22) 14554-14559; https://doi.org/10.1073/pnas.202498299

• Physiology

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    Coupling of c-Src to large conductance voltage- and Ca²⁺-activated K⁺ channels as a new mechanism of agonist-induced vasoconstriction

    Abderrahmane Alioua, Aman Mahajan, Kazuhide Nishimaru, Masoud M. Zarei, Enrico Stefani, and Ligia Toro

    PNAS October 29, 2002 99 (22) 14560-14565; https://doi.org/10.1073/pnas.222348099
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    Nicotinic acid-adenine dinucleotide phosphate-sensitive calcium stores initiate insulin signaling in human beta cells

    James D. Johnson and Stanley Misler

    PNAS October 29, 2002 99 (22) 14566-14571; https://doi.org/10.1073/pnas.222099799
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    Na pump isoforms in human erythroid progenitor cells and mature erythrocytes

    Joseph F. Hoffman, Amittha Wickrema, Olga Potapova, Mark Milanick, and Douglas R. Yingst

    PNAS October 29, 2002 99 (22) 14572-14577; https://doi.org/10.1073/pnas.222539999

• Plant Biology

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    Bottlenecks for metabolic engineering of isoflavone glycoconjugates in Arabidopsis

    Chang-Jun Liu, Jack W. Blount, Christopher L. Steele, and Richard A. Dixon

    PNAS October 29, 2002 99 (22) 14578-14583; https://doi.org/10.1073/pnas.212522099
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    Interphase chromosomes in Arabidopsis are organized as well defined chromocenters from which euchromatin loops emanate

    Paul Fransz, J. Hans de Jong, Martin Lysak, Monica Ruffini Castiglione, and Ingo Schubert

    PNAS October 29, 2002 99 (22) 14584-14589; https://doi.org/10.1073/pnas.212325299

• Population Biology

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    Wind-dispersed pollen mediates postglacial gene flow among refugia

    Sascha Liepelt, Ronald Bialozyt, and Birgit Ziegenhagen

    PNAS October 29, 2002 99 (22) 14590-14594; https://doi.org/10.1073/pnas.212285399

• Psychology (Biological Sciences)

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    Fractionating the neural substrate of cognitive control processes

    Jean-Claude Dreher and Karen Faith Berman

    PNAS October 29, 2002 99 (22) 14595-14600; https://doi.org/10.1073/pnas.222193299
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    Auditory system: Peripheral nonlinearity and central additivity, as revealed in the human stapedius-muscle reflex

    Jozef J. Zwislocki

    PNAS October 29, 2002 99 (22) 14601-14606; https://doi.org/10.1073/pnas.222543199