Table of Contents

Biological Sciences

• Agricultural Sciences

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    Bacillus thuringiensis-toxin resistance management: Stable isotope assessment of alternate host use by Helicoverpazea

    F. Gould, N. Blair, M. Reid, T. L. Rennie, J. Lopez, and S. Micinski

    PNAS December 24, 2002 99 (26) 16581-16586; https://doi.org/10.1073/pnas.242382499

• Applied Biological Sciences

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    Directed evolution of a genetic circuit

    • From the Cover

    Yohei Yokobayashi, Ron Weiss, and Frances H. Arnold

    PNAS December 24, 2002 99 (26) 16587-16591; https://doi.org/10.1073/pnas.252535999

    See companion article:

    • Design then mutate

      - Dec 16, 2002
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    Photoresponsive polymer–enzyme switches

    Tsuyoshi Shimoboji, Edmund Larenas, Tim Fowler, Samarth Kulkarni, Allan S. Hoffman, and Patrick S. Stayton

    PNAS December 24, 2002 99 (26) 16592-16596; https://doi.org/10.1073/pnas.262427799

• Biochemistry

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    Chemical complementation: A reaction-independent genetic assay for enzyme catalysis

    • From the Cover

    Kathleen Baker, Colleen Bleczinski, Hening Lin, Gilda Salazar-Jimenez, Debleena Sengupta, Sonja Krane, and Virginia W. Cornish

    PNAS December 24, 2002 99 (26) 16537-16542; https://doi.org/10.1073/pnas.262420099

    See companion article:

    • Gene function: Getting specific, generally speaking

      - Dec 16, 2002
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    Noninvasive real-time imaging of apoptosis

    Bharathi Laxman, Daniel E. Hall, Mahaveer Swaroop Bhojani, Daniel A. Hamstra, Thomas L. Chenevert, Brian D. Ross, and Alnawaz Rehemtulla

    PNAS December 24, 2002 99 (26) 16551-16555; https://doi.org/10.1073/pnas.252644499
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    Ten-nanosecond molecular dynamics simulation of the motions of the horse liver alcohol dehydrogenase⋅PhCH₂O⁻ complex

    Jia Luo and Thomas C. Bruice

    PNAS December 24, 2002 99 (26) 16597-16600; https://doi.org/10.1073/pnas.262667599
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    CUL7: A DOC domain-containing cullin selectively binds Skp1⋅Fbx29 to form an SCF-like complex

    Dora C. Dias, Georgia Dolios, Rong Wang, and Zhen-Qiang Pan

    PNAS December 24, 2002 99 (26) 16601-16606; https://doi.org/10.1073/pnas.252646399
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    Common denominator of Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis: Decreased stability of the apo state

    Mikael J. Lindberg, Lena Tibell, and Mikael Oliveberg

    PNAS December 24, 2002 99 (26) 16607-16612; https://doi.org/10.1073/pnas.262527099
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    A unique molecular chaperone Cosmc required for activity of the mammalian core 1 β3-galactosyltransferase

    Tongzhong Ju and Richard D. Cummings

    PNAS December 24, 2002 99 (26) 16613-16618; https://doi.org/10.1073/pnas.262438199
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    Direct inhibition by nitric oxide of the transcriptional ferric uptake regulation protein via nitrosylation of the iron

    Benoît D'Autréaux, Danièle Touati, Beate Bersch, Jean-Marc Latour, and Isabelle Michaud-Soret

    PNAS December 24, 2002 99 (26) 16619-16624; https://doi.org/10.1073/pnas.252591299
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    Anaerobic enzyme⋅substrate structures provide insight into the reaction mechanism of the copper-dependent quercetin 2,3-dioxygenase

    Roberto A. Steiner, Kor H. Kalk, and Bauke W. Dijkstra

    PNAS December 24, 2002 99 (26) 16625-16630; https://doi.org/10.1073/pnas.262506299
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    Trbp111 selectively binds a noncovalently assembled tRNA-like structure

    Tetsuo Kushiro and Paul Schimmel

    PNAS December 24, 2002 99 (26) 16631-16635; https://doi.org/10.1073/pnas.262667999
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    Identification and cloning of human polynucleotide phosphorylase, hPNPase^old-35, in the context of terminal differentiation and cellular senescence

    Magdalena Leszczyniecka, Dong-chul Kang, Devanand Sarkar, Zao-zhong Su, Matthew Holmes, Kristoffer Valerie, and Paul B. Fisher

    PNAS December 24, 2002 99 (26) 16636-16641; https://doi.org/10.1073/pnas.252643699
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    The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter

    Elizabeth L. Borths, Kaspar P. Locher, Allen T. Lee, and Douglas C. Rees

    PNAS December 24, 2002 99 (26) 16642-16647; https://doi.org/10.1073/pnas.262659699
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    Dicer is required for chromosome segregation and gene silencing in fission yeast cells

    Patrick Provost, Rebecca A. Silverstein, David Dishart, Julian Walfridsson, Ingela Djupedal, Barbara Kniola, Anthony Wright, Bengt Samuelsson, Olof Rådmark, and Karl Ekwall

    PNAS December 24, 2002 99 (26) 16648-16653; https://doi.org/10.1073/pnas.212633199
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    Excision of misincorporated ribonucleotides in DNA by RNase H (type 2) and FEN-1 in cell-free extracts

    Bjorn Rydberg and John Game

    PNAS December 24, 2002 99 (26) 16654-16659; https://doi.org/10.1073/pnas.262591699
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    Reversal of DNA alkylation damage by two human dioxygenases

    Tod Duncan, Sarah C. Trewick, Pertti Koivisto, Paul A. Bates, Tomas Lindahl, and Barbara Sedgwick

    PNAS December 24, 2002 99 (26) 16660-16665; https://doi.org/10.1073/pnas.262589799
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    Z-DNA-binding proteins can act as potent effectors of gene expression in vivo

    Doo-Byoung Oh, Yang-Gyun Kim, and Alexander Rich

    PNAS December 24, 2002 99 (26) 16666-16671; https://doi.org/10.1073/pnas.262672699
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    Three mutations in sterol-sensing domain of SCAP block interaction with insig and render SREBP cleavage insensitive to sterols

    Daisuke Yabe, Zong-Ping Xia, Christopher M. Adams, and Robert B. Rawson

    PNAS December 24, 2002 99 (26) 16672-16677; https://doi.org/10.1073/pnas.262669399
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    A polyphosphate kinase (PPK2) widely conserved in bacteria

    Haiyu Zhang, Kazuya Ishige, and Arthur Kornberg

    PNAS December 24, 2002 99 (26) 16678-16683; https://doi.org/10.1073/pnas.262655199
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    Polyphosphate kinase (PPK2), a potent, polyphosphate-driven generator of GTP

    Kazuya Ishige, Haiyu Zhang, and Arthur Kornberg

    PNAS December 24, 2002 99 (26) 16684-16688; https://doi.org/10.1073/pnas.262655299
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    Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation

    Joon H. Lee, Tatyana V. Pestova, Byung-Sik Shin, Chune Cao, Sang K. Choi, and Thomas E. Dever

    PNAS December 24, 2002 99 (26) 16689-16694; https://doi.org/10.1073/pnas.262569399
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    Site-directed recombination via bifunctional PNA–DNA conjugates

    Faye A. Rogers, Karen M. Vasquez, Michael Egholm, and Peter M. Glazer

    PNAS December 24, 2002 99 (26) 16695-16700; https://doi.org/10.1073/pnas.262556899
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    Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts

    Inez Rogatsky, Hans F. Luecke, Dale C. Leitman, and Keith R. Yamamoto

    PNAS December 24, 2002 99 (26) 16701-16706; https://doi.org/10.1073/pnas.262671599
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    Orthologs of a novel archaeal and of the bacterial peptidyl–tRNA hydrolase are nonessential in yeast

    Guillermina Rosas-Sandoval, Alexandre Ambrogelly, Jesse Rinehart, David Wei, L. Rogelio Cruz-Vera, David E. Graham, Karl O. Stetter, Gabriel Guarneros, and Dieter Söll

    PNAS December 24, 2002 99 (26) 16707-16712; https://doi.org/10.1073/pnas.222659199
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    Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension

    Joshua P. Fessel, Ned A. Porter, Kevin P. Moore, James R. Sheller, and L. Jackson Roberts II

    PNAS December 24, 2002 99 (26) 16713-16718; https://doi.org/10.1073/pnas.252649099
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    Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method

    Klaus Hartmuth, Henning Urlaub, Hans-Peter Vornlocher, Cindy L. Will, Marc Gentzel, Matthias Wilm, and Reinhard Lührmann

    PNAS December 24, 2002 99 (26) 16719-16724; https://doi.org/10.1073/pnas.262483899
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    Topology of the Ca²⁺ release channel of skeletal muscle sarcoplasmic reticulum (RyR1)

    Guo Guang Du, Bimal Sandhu, Vijay K. Khanna, Xing Hua Guo, and David H. MacLennan

    PNAS December 24, 2002 99 (26) 16725-16730; https://doi.org/10.1073/pnas.012688999
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    Mechanism of regulation of phosphate dissociation from actomyosin-ADP-Pi by thin filament proteins

    David H. Heeley, Betty Belknap, and Howard D. White

    PNAS December 24, 2002 99 (26) 16731-16736; https://doi.org/10.1073/pnas.252236399

• Biophysics

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    Stabilizing the integrin αM inserted domain in alternative conformations with a range of engineered disulfide bonds

    Motomu Shimaoka, Chafen Lu, Azucena Salas, Tsan Xiao, Junichi Takagi, and Timothy A. Springer

    PNAS December 24, 2002 99 (26) 16737-16741; https://doi.org/10.1073/pnas.252633099
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    A structural model for Alzheimer's β-amyloid fibrils based on experimental constraints from solid state NMR

    Aneta T. Petkova, Yoshitaka Ishii, John J. Balbach, Oleg N. Antzutkin, Richard D. Leapman, Frank Delaglio, and Robert Tycko

    PNAS December 24, 2002 99 (26) 16742-16747; https://doi.org/10.1073/pnas.262663499

    See companion article:

    • Unraveling the secrets of Alzheimer's β-amyloid fibrils

      - Jan 13, 2003
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    Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril

    Christopher P. Jaroniec, Cait E. MacPhee, Nathan S. Astrof, Christopher M. Dobson, and Robert G. Griffin

    PNAS December 24, 2002 99 (26) 16748-16753; https://doi.org/10.1073/pnas.252625999
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    Spin-dependent mechanism for diatomic ligand binding to heme

    Stefan Franzen

    PNAS December 24, 2002 99 (26) 16754-16759; https://doi.org/10.1073/pnas.252590999
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    Carotenoid to chlorophyll energy transfer in the peridinin–chlorophyll-a–protein complex involves an intramolecular charge transfer state

    Donatas Zigmantas, Roger G. Hiller, Villy Sundström, and Tomáš Polívka

    PNAS December 24, 2002 99 (26) 16760-16765; https://doi.org/10.1073/pnas.262537599
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    Stomatocyte–discocyte–echinocyte sequence of the human red blood cell: Evidence for the bilayer– couple hypothesis from membrane mechanics

    Gerald Lim H. W., Michael Wortis, and Ranjan Mukhopadhyay

    PNAS December 24, 2002 99 (26) 16766-16769; https://doi.org/10.1073/pnas.202617299

• Cell Biology

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    Stomatocyte–discocyte–echinocyte sequence of the human red blood cell: Evidence for the bilayer– couple hypothesis from membrane mechanics

    Gerald Lim H. W., Michael Wortis, and Ranjan Mukhopadhyay

    PNAS December 24, 2002 99 (26) 16766-16769; https://doi.org/10.1073/pnas.202617299
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    Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFκB, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line

    Emily Ho and Bruce N. Ames

    PNAS December 24, 2002 99 (26) 16770-16775; https://doi.org/10.1073/pnas.222679399
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    Dynamic assembly of MinD into filament bundles modulated by ATP, phospholipids, and MinE

    Kyoko Suefuji, Regina Valluzzi, and Debabrata RayChaudhuri

    PNAS December 24, 2002 99 (26) 16776-16781; https://doi.org/10.1073/pnas.262671699
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    Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts

    Hervé Falet, Karin M. Hoffmeister, Ralph Neujahr, Joseph E. Italiano Jr., Thomas P. Stossel, Frederick S. Southwick, and John H. Hartwig

    PNAS December 24, 2002 99 (26) 16782-16787; https://doi.org/10.1073/pnas.222652499
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    Dynamics of microtubule asters in microfabricated chambers: The role of catastrophes

    Cendrine Faivre-Moskalenko and Marileen Dogterom

    PNAS December 24, 2002 99 (26) 16788-16793; https://doi.org/10.1073/pnas.252407099
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    G₂ arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A

    Brian C. Duckworth, Jennifer S. Weaver, and Joan V. Ruderman

    PNAS December 24, 2002 99 (26) 16794-16799; https://doi.org/10.1073/pnas.222661299
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    cAMP-independent role of PKA in tonicity-induced transactivation of tonicity-responsive enhancer/ osmotic response element-binding protein

    Joan D. Ferraris, Prita Persaud, Chester K. Williams, Ye Chen, and Maurice B. Burg

    PNAS December 24, 2002 99 (26) 16800-16805; https://doi.org/10.1073/pnas.222659799
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    Imaging direct, dynamin-dependent recapture of fusing secretory granules on plasma membrane lawns from PC12 cells

    Phillip Holroyd, Thorsten Lang, Dirk Wenzel, Pietro De Camilli, and Reinhard Jahn

    PNAS December 24, 2002 99 (26) 16806-16811; https://doi.org/10.1073/pnas.222677399

• Ecology

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    Crop pollination from native bees at risk from agricultural intensification

    Claire Kremen, Neal M. Williams, and Robbin W. Thorp

    PNAS December 24, 2002 99 (26) 16812-16816; https://doi.org/10.1073/pnas.262413599
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    Satellite imagery characterizes local animal reservoir populations of Sin Nombre virus in the southwestern United States

    Gregory E. Glass, Terry L. Yates, Joshua B. Fine, Timothy M. Shields, John B. Kendall, Andrew G. Hope, Cheryl A. Parmenter, C. J. Peters, Thomas G. Ksiazek, Chung-Sheng Li, Jonathan A. Patz, and James N. Mills

    PNAS December 24, 2002 99 (26) 16817-16822; https://doi.org/10.1073/pnas.252617999
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    Interaction of pollinators and herbivores on plant fitness suggests a pathway for correlated evolution of mutualism- and antagonism-related traits

    Carlos M. Herrera, Mónica Medrano, Pedro J. Rey, Alfonso M. Sánchez-Lafuente, María B. García, Javier Guitián, and Antonio J. Manzaneda

    PNAS December 24, 2002 99 (26) 16823-16828; https://doi.org/10.1073/pnas.252362799

• Evolution

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    Differential lipid biosynthesis underlies a tradeoff between reproduction and flight capability in a wing-polymorphic cricket

    Zhangwu Zhao and Anthony J. Zera

    PNAS December 24, 2002 99 (26) 16829-16834; https://doi.org/10.1073/pnas.262533999
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    Allopolyploidization and evolution of species with reduced floral structures in Lepidium L. (Brassicaceae)

    Ji-Young Lee, Klaus Mummenhoff, and John L. Bowman

    PNAS December 24, 2002 99 (26) 16835-16840; https://doi.org/10.1073/pnas.242415399
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    Modularity and reshuffling of Snail and Slug expression during vertebrate evolution

    Annamaria Locascio, Miguel Manzanares, María J. Blanco, and M. Angela Nieto

    PNAS December 24, 2002 99 (26) 16841-16846; https://doi.org/10.1073/pnas.262525399

• Genetics

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    Characterization of the intergenic RNA profile at abdominal-A and Abdominal-B in the Drosophila bithorax complex

    Esther Bae, Vincent C. Calhoun, Michael Levine, Edward B. Lewis, and Robert A. Drewell

    PNAS December 24, 2002 99 (26) 16847-16852; https://doi.org/10.1073/pnas.222671299
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    Transcription defines the embryonic domains of cis-regulatory activity at the Drosophila bithorax complex

    Robert A. Drewell, Esther Bae, John Burr, and Edward B. Lewis

    PNAS December 24, 2002 99 (26) 16853-16858; https://doi.org/10.1073/pnas.222671199
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    Genetic variation in the 22q11 locus and susceptibility to schizophrenia

    Hui Liu, Gonçalo R. Abecasis, Simon C. Heath, Alyson Knowles, Sandra Demars, Ying-Jiun Chen, J. Louw Roos, Judith L. Rapoport, Joseph A. Gogos, and Maria Karayiorgou

    PNAS December 24, 2002 99 (26) 16859-16864; https://doi.org/10.1073/pnas.232186099
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    ARF mutation accelerates pituitary tumor development in Rb+/− mice

    Kenneth Y. Tsai, David MacPherson, Douglas A. Rubinson, Alexander Yu. Nikitin, Roderick Bronson, Kim L. Mercer, Denise Crowley, and Tyler Jacks

    PNAS December 24, 2002 99 (26) 16865-16870; https://doi.org/10.1073/pnas.262499599
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    Association testing by DNA pooling: An effective initial screen

    Aruna Bansal, Dirk van den Boom, Stefan Kammerer, Christiane Honisch, Gail Adam, Charles R. Cantor, Patrick Kleyn, and Andi Braun

    PNAS December 24, 2002 99 (26) 16871-16874; https://doi.org/10.1073/pnas.262671399
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    Genome-wide coexpression dynamics: Theory and application

    Ker-Chau Li

    PNAS December 24, 2002 99 (26) 16875-16880; https://doi.org/10.1073/pnas.252466999
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    The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration

    Xinhe Wang, Hiroaki Kiyokawa, Margaret B. Dennewitz, and Robert H. Costa

    PNAS December 24, 2002 99 (26) 16881-16886; https://doi.org/10.1073/pnas.252570299
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    Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication

    Francis Fabre, Allan Chan, Wolf-Dietrich Heyer, and Serge Gangloff

    PNAS December 24, 2002 99 (26) 16887-16892; https://doi.org/10.1073/pnas.252652399
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    A systematic approach to reconstructing transcription networks in Saccharomyces cerevisiae

    Wei Wang, J. Michael Cherry, David Botstein, and Hao Li

    PNAS December 24, 2002 99 (26) 16893-16898; https://doi.org/10.1073/pnas.252638199
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    Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

    Mammalian Gene Collection (MGC) Program Team*

    PNAS December 24, 2002 99 (26) 16899-16903; https://doi.org/10.1073/pnas.242603899
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    An ensemble method for identifying regulatory circuits with special reference to the qa gene cluster of Neurospora crassa

    D. Battogtokh, D. K. Asch, M. E. Case, J. Arnold, and H.-B. Schüttler

    PNAS December 24, 2002 99 (26) 16904-16909; https://doi.org/10.1073/pnas.262658899
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    Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC

    O. M. Sieber, K. Heinimann, P. Gorman, H. Lamlum, M. Crabtree, C. A. Simpson, D. Davies, K. Neale, S. V. Hodgson, R. R. Roylance, R. K. S. Phillips, W. F. Bodmer, and I. P. M. Tomlinson

    PNAS December 24, 2002 99 (26) 16910-16915; https://doi.org/10.1073/pnas.012679099
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    The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a

    Frédéric Chédin, Michael R. Lieber, and Chih-Lin Hsieh

    PNAS December 24, 2002 99 (26) 16916-16921; https://doi.org/10.1073/pnas.262443999
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    Genetic analysis of iron citrate toxicity in yeast: Implications for mammalian iron homeostasis

    Opal S. Chen, Shawn Hemenway, and Jerry Kaplan

    PNAS December 24, 2002 99 (26) 16922-16927; https://doi.org/10.1073/pnas.232392299
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    High-throughput screening for evidence of association by using mass spectrometry genotyping on DNA pools

    Karen L. Mohlke, Michael R. Erdos, Laura J. Scott, Tasha E. Fingerlin, Anne U. Jackson, Kaisa Silander, Pablo Hollstein, Michael Boehnke, and Francis S. Collins

    PNAS December 24, 2002 99 (26) 16928-16933; https://doi.org/10.1073/pnas.262661399
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    A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage

    Michael Chang, Mohammed Bellaoui, Charles Boone, and Grant W. Brown

    PNAS December 24, 2002 99 (26) 16934-16939; https://doi.org/10.1073/pnas.262669299
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    Associations between human disease genes and overlapping gene groups and multiple amino acid runs

    Samuel Karlin, Chingfer Chen, Andrew J. Gentles, and Michael Cleary

    PNAS December 24, 2002 99 (26) 17008-17013; https://doi.org/10.1073/pnas.262658799

• Immunology

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    Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo

    Adrian Erlebacher, Amanda K. Lukens, and Laurie H. Glimcher

    PNAS December 24, 2002 99 (26) 16940-16945; https://doi.org/10.1073/pnas.222652199
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    A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules

    Olaf Rötzschke, Julie M. Lau, Maria Hofstätter, Kirsten Falk, and Jack L. Strominger

    PNAS December 24, 2002 99 (26) 16946-16950; https://doi.org/10.1073/pnas.212643999
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    Disruption of T helper 2-immune responses in Epstein–Barr virus-induced gene 3-deficient mice

    Edward E. S. Nieuwenhuis, Markus F. Neurath, Nadia Corazza, Hideki Iijima, Joanne Trgovcich, Stefan Wirtz, Jonathan Glickman, Dan Bailey, Masaru Yoshida, Peter R. Galle, Mitchell Kronenberg, Mark Birkenbach, and Richard S. Blumberg

    PNAS December 24, 2002 99 (26) 16951-16956; https://doi.org/10.1073/pnas.252648899
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    The promoter of IL-18 binding protein: Activation by an IFN-γ-induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein β

    Vladimir Hurgin, Daniela Novick, and Menachem Rubinstein

    PNAS December 24, 2002 99 (26) 16957-16962; https://doi.org/10.1073/pnas.262663399
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    Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity

    Philippe Le Bouteiller, Aliz Barakonyi, Jérome Giustiniani, Françoise Lenfant, Anne Marie-Cardine, Maryse Aguerre-Girr, Magali Rabot, Ivan Hilgert, Fathia Mami-Chouaib, Julie Tabiasco, Laurence Boumsell, and Armand Bensussan

    PNAS December 24, 2002 99 (26) 16963-16968; https://doi.org/10.1073/pnas.012681099
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    The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice

    Jeremy S. Brown, Tracy Hussell, Sarah M. Gilliland, David W. Holden, James C. Paton, Michael R. Ehrenstein, Mark J. Walport, and Marina Botto

    PNAS December 24, 2002 99 (26) 16969-16974; https://doi.org/10.1073/pnas.012669199

• Medical Sciences

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    POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer

    Tapan K. Bera, Drazen B. Zimonjic, Nicholas C. Popescu, Bangalore K. Sathyanarayana, Vasantha Kumar, Byungkook Lee, and Ira Pastan

    PNAS December 24, 2002 99 (26) 16975-16980; https://doi.org/10.1073/pnas.262655399
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    Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations

    Feng Qian, Alessandra Boletta, Anil K. Bhunia, Hangxue Xu, Lijuan Liu, Ali K. Ahrabi, Terry J. Watnick, Fang Zhou, and Gregory G. Germino

    PNAS December 24, 2002 99 (26) 16981-16986; https://doi.org/10.1073/pnas.252484899
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    More antibody with less antigen: Can immunogenicity of attenuated live virus vaccines be improved?

    Alexander Bukreyev, Mario H. Skiadopoulos, Josephine McAuliffe, Brian R. Murphy, Peter L. Collins, and Alexander C. Schmidt

    PNAS December 24, 2002 99 (26) 16987-16991; https://doi.org/10.1073/pnas.252649299
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    Hyperinsulinism induced by targeted suppression of beta cell K_ATP channels

    J. C. Koster, M. S. Remedi, T. P. Flagg, J. D. Johnson, K. P. Markova, B. A. Marshall, and C. G. Nichols

    PNAS December 24, 2002 99 (26) 16992-16997; https://doi.org/10.1073/pnas.012479199
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    A molecular switch underlies a human telomerase disease

    Luis R. Comolli, Ivan Smirnov, Lifeng Xu, Elizabeth H. Blackburn, and Thomas L. James

    PNAS December 24, 2002 99 (26) 16998-17003; https://doi.org/10.1073/pnas.262663599
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    Properties of linkage disequilibrium (LD) maps

    Weilhua Zhang, Andrew Collins, Nikolas Maniatis, William Tapper, and Newton E. Morton

    PNAS December 24, 2002 99 (26) 17004-17007; https://doi.org/10.1073/pnas.012672899
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    Associations between human disease genes and overlapping gene groups and multiple amino acid runs

    Samuel Karlin, Chingfer Chen, Andrew J. Gentles, and Michael Cleary

    PNAS December 24, 2002 99 (26) 17008-17013; https://doi.org/10.1073/pnas.262658799
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    Mutational analysis of the structural organization of polyglutamine aggregates

    Ashwani K. Thakur and Ronald Wetzel

    PNAS December 24, 2002 99 (26) 17014-17019; https://doi.org/10.1073/pnas.252523899

    See companion article:

    • Polyglutamine fibrillogenesis: The pathway unfolds

      - Dec 30, 2002
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    Functional reorganization and stability of somatosensory-motor cortical topography in a tetraplegic subject with late recovery

    Maurizio Corbetta, Harold Burton, Robert J. Sinclair, Thomas E. Conturo, Erbil Akbudak, and John W. McDonald

    PNAS December 24, 2002 99 (26) 17066-17071; https://doi.org/10.1073/pnas.262669099

• Microbiology

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    Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli

    R. A. Welch, V. Burland, G. Plunkett III, P. Redford, P. Roesch, D. Rasko, E. L. Buckles, S.-R. Liou, A. Boutin, J. Hackett, D. Stroud, G. F. Mayhew, D. J. Rose, S. Zhou, D. C. Schwartz, N. T. Perna, H. L. T. Mobley, M. S. Donnenberg, and F. R. Blattner

    PNAS December 24, 2002 99 (26) 17020-17024; https://doi.org/10.1073/pnas.252529799
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    Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics

    Ee-Been Goh, Grace Yim, Wayne Tsui, JoAnn McClure, Michael G. Surette, and Julian Davies

    PNAS December 24, 2002 99 (26) 17025-17030; https://doi.org/10.1073/pnas.252607699
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    The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene

    Brunella Taddeo, Audrey Esclatine, and Bernard Roizman

    PNAS December 24, 2002 99 (26) 17031-17036; https://doi.org/10.1073/pnas.252588599
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    Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach

    Joseph D. Mougous, Michael D. Leavell, Ryan H. Senaratne, Clifton D. Leigh, Spencer J. Williams, Lee W. Riley, Julie A. Leary, and Carolyn R. Bertozzi

    PNAS December 24, 2002 99 (26) 17037-17042; https://doi.org/10.1073/pnas.252514899
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    Genomic diversity of enterohemorrhagic Escherichia coli O157 revealed by whole genome PCR scanning

    Makoto Ohnishi, Jun Terajima, Ken Kurokawa, Keisuke Nakayama, Takahiro Murata, Kazumichi Tamura, Yoshitoshi Ogura, Haruo Watanabe, and Tetsuya Hayashi

    PNAS December 24, 2002 99 (26) 17043-17048; https://doi.org/10.1073/pnas.262441699
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    Genes for the cytoskeletal protein tubulin in the bacterial genus Prosthecobacter

    Cheryl Jenkins, Ram Samudrala, Iain Anderson, Brian P. Hedlund, Giulio Petroni, Natasha Michailova, Nicolas Pinel, Ross Overbeek, Giovanna Rosati, and James T. Staley

    PNAS December 24, 2002 99 (26) 17049-17054; https://doi.org/10.1073/pnas.012516899

• Neuroscience

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    Sensitization of regulated exocytosis by protein kinase C

    • From the Cover

    Hongliang Zhu, Bertil Hille, and Tao Xu

    PNAS December 24, 2002 99 (26) 17055-17059; https://doi.org/10.1073/pnas.232588899

    See companion article:

    • Specificity emerges in the dissection of diacylglycerol- and protein kinase C-mediated signalling pathways

      - Dec 16, 2002
  • You have access

    A highly Ca²⁺-sensitive pool of vesicles is regulated by protein kinase C in adrenal chromaffin cells

    Yan Yang, Sangeetha Udayasankar, James Dunning, Peng Chen, and Kevin D. Gillis

    PNAS December 24, 2002 99 (26) 17060-17065; https://doi.org/10.1073/pnas.242624699

    See companion article:

    • Specificity emerges in the dissection of diacylglycerol- and protein kinase C-mediated signalling pathways

      - Dec 16, 2002
  • You have access

    Functional reorganization and stability of somatosensory-motor cortical topography in a tetraplegic subject with late recovery

    Maurizio Corbetta, Harold Burton, Robert J. Sinclair, Thomas E. Conturo, Erbil Akbudak, and John W. McDonald

    PNAS December 24, 2002 99 (26) 17066-17071; https://doi.org/10.1073/pnas.262669099
  • You have access

    Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel β2-subunits

    Chunling Chen, Vandana Bharucha, Yuan Chen, Ruth E. Westenbroek, Angus Brown, Jyoti Dhar Malhotra, Dorothy Jones, Christy Avery, Patrick J. Gillespie III, Kristin A. Kazen-Gillespie, Katie Kazarinova-Noyes, Peter Shrager, Thomas L. Saunders, Robert L. Macdonald, Bruce R. Ransom, Todd Scheuer, William A. Catterall, and Lori L. Isom

    PNAS December 24, 2002 99 (26) 17072-17077; https://doi.org/10.1073/pnas.212638099
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    Evidence for vestibular regulation of autonomic functions in a mouse genetic model

    Dean M. Murakami, Linda Erkman, Ola Hermanson, Michael G. Rosenfeld, and Charles A. Fuller

    PNAS December 24, 2002 99 (26) 17078-17082; https://doi.org/10.1073/pnas.252652299
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    The role of feedback in shaping neural representations in cat visual cortex

    Ralf A. W. Galuske, Kerstin E. Schmidt, Rainer Goebel, Stephen G. Lomber, and Bertram R. Payne

    PNAS December 24, 2002 99 (26) 17083-17088; https://doi.org/10.1073/pnas.242399199
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    Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry

    Ulrica Englund, Anders Björklund, Klas Wictorin, Olle Lindvall, and Merab Kokaia

    PNAS December 24, 2002 99 (26) 17089-17094; https://doi.org/10.1073/pnas.252589099
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    An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability

    L. Tremolizzo, G. Carboni, W. B. Ruzicka, C. P. Mitchell, I. Sugaya, P. Tueting, R. Sharma, D. R. Grayson, E. Costa, and A. Guidotti

    PNAS December 24, 2002 99 (26) 17095-17100; https://doi.org/10.1073/pnas.262658999
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    Longitudinal pattern of basilar membrane vibration in the sensitive cochlea

    Tianying Ren

    PNAS December 24, 2002 99 (26) 17101-17106; https://doi.org/10.1073/pnas.262663699
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    Protection against ischemic brain injury by protein therapeutics

    Sadamitsu Asoh, Ikuroh Ohsawa, Takashi Mori, Ken-ichiro Katsura, Tomoharu Hiraide, Yasuo Katayama, Megumi Kimura, Daiya Ozaki, Kumi Yamagata, and Shigeo Ohta

    PNAS December 24, 2002 99 (26) 17107-17112; https://doi.org/10.1073/pnas.262460299
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    A possible substrate for dopamine-related changes in mood and behavior: Prefrontal and limbic effects of a D3-preferring dopamine agonist

    Kevin J. Black, Tamara Hershey, Jonathan M. Koller, Tom O. Videen, Mark A. Mintun, Joseph L. Price, and Joel S. Perlmutter

    PNAS December 24, 2002 99 (26) 17113-17118; https://doi.org/10.1073/pnas.012260599
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    A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling

    Helena Karlström, Paul Beatus, Karin Dannaeus, Gavin Chapman, Urban Lendahl, and Johan Lundkvist

    PNAS December 24, 2002 99 (26) 17119-17124; https://doi.org/10.1073/pnas.252624099
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    Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons

    Alberto Bacci, John R. Huguenard, and David A. Prince

    PNAS December 24, 2002 99 (26) 17125-17130; https://doi.org/10.1073/pnas.012481899
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    Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity

    Peter W. Faber, Cindy Voisine, Daphne C. King, Emily A. Bates, and Anne C. Hart

    PNAS December 24, 2002 99 (26) 17131-17136; https://doi.org/10.1073/pnas.262544899
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    Neural correlates of perceptual learning: A functional MRI study of visual texture discrimination

    Sophie Schwartz, Pierre Maquet, and Chris Frith

    PNAS December 24, 2002 99 (26) 17137-17142; https://doi.org/10.1073/pnas.242414599

    See companion article:

    • Linking brain and behavior in sleep-dependent learning and memory consolidation

      - Dec 16, 2002
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    Delayed reentry of recycling vesicles into the fusion-competent synaptic vesicle pool in synaptojanin 1 knockout mice

    Warren T. Kim, Sunghoe Chang, Laurie Daniell, Ottavio Cremona, Gilbert Di Paolo, and Pietro De Camilli

    PNAS December 24, 2002 99 (26) 17143-17148; https://doi.org/10.1073/pnas.222657399
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    Can the Ca²⁺ hypothesis and the Ca²⁺-voltage hypothesis for neurotransmitter release be reconciled?

    Hanna Parnas, J.-C. Valle-Lisboa, and Lee A. Segel

    PNAS December 24, 2002 99 (26) 17149-17154; https://doi.org/10.1073/pnas.242549999
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    Autoantibodies against α-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients

    Sergueï O. Fetissov, Jarmila Hallman, Lars Oreland, Britt af Klinteberg, Eva Grenbäck, Anna-Lena Hulting, and Tomas Hökfelt

    PNAS December 24, 2002 99 (26) 17155-17160; https://doi.org/10.1073/pnas.222658699

• Pharmacology

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    Distribution of nitric oxide synthase in normal and cirrhotic human liver

    Lance McNaughton, Lakshmi Puttagunta, Maria Angeles Martinez-Cuesta, Norm Kneteman, Irvin Mayers, Redwan Moqbel, Qutayba Hamid, and Marek W. Radomski

    PNAS December 24, 2002 99 (26) 17161-17166; https://doi.org/10.1073/pnas.0134112100
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    NOSTRIN: A protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase

    • From the Cover

    Kirstin Zimmermann, Nils Opitz, Jürgen Dedio, Christoph Renné, Werner Müller-Esterl, and Stefanie Oess

    PNAS December 24, 2002 99 (26) 17167-17172; https://doi.org/10.1073/pnas.252345399

    See companion article:

    • There's NO binding like NOS binding: Protein–protein interactions in NO/cGMP signaling

      - Dec 16, 2002
  • You have access

    Reversible infertility in male mice after oral administration of alkylated imino sugars: A nonhormonal approach to male contraception

    Aarnoud C. van der Spoel, Mylvaganam Jeyakumar, Terry D. Butters, Harry M. Charlton, Harry D. Moore, Raymond A. Dwek, and Frances M. Platt

    PNAS December 24, 2002 99 (26) 17173-17178; https://doi.org/10.1073/pnas.262586099
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    A-317491, a novel potent and selective non-nucleotide antagonist of P2X₃ and P2X_2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat

    Michael F. Jarvis, Edward C. Burgard, Steve McGaraughty, Prisca Honore, Kevin Lynch, Timothy J. Brennan, Alberto Subieta, Tim van Biesen, Jayne Cartmell, Bruce Bianchi, Wende Niforatos, Karen Kage, Haixia Yu, Joe Mikusa, Carol T. Wismer, Chang Z. Zhu, Katharine Chu, Chih-Hung Lee, Andrew O. Stewart, James Polakowski, Bryan F. Cox, Elizabeth Kowaluk, Michael Williams, James Sullivan, and Connie Faltynek

    PNAS December 24, 2002 99 (26) 17179-17184; https://doi.org/10.1073/pnas.252537299

• Physiology

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    Engineered calmodulins reveal the unexpected eminence of Ca²⁺ channel inactivation in controlling heart excitation

    Badr A. Alseikhan, Carla D. DeMaria, Henry M. Colecraft, and David T. Yue

    PNAS December 24, 2002 99 (26) 17185-17190; https://doi.org/10.1073/pnas.262372999
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    Phosphodiesterase expression targeted to gonadotropin-releasing hormone neurons inhibits luteinizing hormone pulses in transgenic rats

    Sreenivasan Paruthiyil, Mohammed El Majdoubi, Marco Conti, and Richard I. Weiner

    PNAS December 24, 2002 99 (26) 17191-17196; https://doi.org/10.1073/pnas.012678999

• Plant Biology

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    Increased level of hemoglobin 1 enhances survival of hypoxic stress and promotes early growth in Arabidopsis thaliana

    P. W. Hunt, E. J. Klok, B. Trevaskis, R. A. Watts, M. H. Ellis, W. J. Peacock, and E. S. Dennis

    PNAS December 24, 2002 99 (26) 17197-17202; https://doi.org/10.1073/pnas.212648799
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    Circadian clock protein KaiC forms ATP-dependent hexameric rings and binds DNA

    Tetsuya Mori, Sergei V. Saveliev, Yao Xu, Walter F. Stafford, Michael M. Cox, Ross B. Inman, and Carl H. Johnson

    PNAS December 24, 2002 99 (26) 17203-17208; https://doi.org/10.1073/pnas.262578499

• Population Biology

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    Dynamics and selection of many-strain pathogens

    Julia R. Gog and Bryan T. Grenfell

    PNAS December 24, 2002 99 (26) 17209-17214; https://doi.org/10.1073/pnas.252512799