The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens

^*Fidelity Systems, Gaithersburg, MD 20879: ^§National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894; ^‡M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117871, Russia; and ^¶Department of Microbiology, University of Regensburg, Regensburg, D-93053, Germany

Communicated by Dieter Söll, Yale University, New Haven, CT (received for review December 3, 2001)

Footnotes

↵† To whom reprint requests should be addressed. E-mail: alex{at}fidelitysystems.com.
Data deposition: The sequence reported in this paper has been deposited in the GenBank database (accession no. AE009439).

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	Abstract	Full	Pdf
Mar 2002	0	1	0
Apr 2002	297	372	463
May 2002	38	234	181
Jun 2002	54	327	164
Jul 2002	24	273	141
Aug 2002	27	204	122
Sep 2002	35	212	93
Oct 2002	32	197	162
Nov 2002	30	83	74
Dec 2002	17	62	49
Total 2002	554	1965	1449
Jan 2003	15	78	64
Feb 2003	36	81	67
Mar 2003	20	57	39
Apr 2003	23	83	55
May 2003	7	60	45
Jun 2003	20	71	59
Jul 2003	35	72	59
Aug 2003	23	52	26
Sep 2003	51	66	67
Oct 2003	49	100	83
Nov 2003	39	80	61
Dec 2003	53	131	64
Total 2003	371	931	689
Jan 2004	65	112	63
Feb 2004	78	118	44
Mar 2004	86	144	111
Apr 2004	65	126	75
May 2004	90	101	50
Jun 2004	75	105	45
Jul 2004	63	118	44
Aug 2004	79	127	42
Sep 2004	78	116	40
Oct 2004	64	243	46
Nov 2004	76	121	64
Dec 2004	78	89	44
Total 2004	897	1520	668
Jan 2005	41	62	30
Feb 2005	41	75	58
Mar 2005	55	104	52
Apr 2005	60	72	37
May 2005	48	108	49
Jun 2005	43	72	31
Jul 2005	37	42	31
Aug 2005	48	63	32
Sep 2005	48	89	35
Oct 2005	58	82	54
Nov 2005	77	107	36
Dec 2005	70	120	61
Total 2005	626	996	506
Jan 2006	43	53	34
Feb 2006	69	77	44
Mar 2006	64	74	40
Apr 2006	42	66	51
May 2006	43	60	39
Jun 2006	47	55	51
Jul 2006	34	39	13
Aug 2006	33	37	28
Sep 2006	51	72	39
Oct 2006	82	65	35
Nov 2006	74	74	48
Dec 2006	50	46	26
Total 2006	632	718	448
Jan 2007	38	60	43
Feb 2007	27	35	26
Mar 2007	60	38	39
Apr 2007	40	56	35
May 2007	58	46	38
Jun 2007	35	32	33
Jul 2007	32	11	23
Aug 2007	25	29	30
Sep 2007	45	45	23
Oct 2007	53	46	39
Nov 2007	39	39	36
Dec 2007	34	51	32
Total 2007	486	488	397
Jan 2008	34	33	25
Feb 2008	33	26	24
Mar 2008	24	24	35
Apr 2008	34	30	49
May 2008	30	32	11
Jun 2008	37	39	19
Jul 2008	68	11	17
Aug 2008	45	12	15
Sep 2008	63	38	36
Oct 2008	29	34	25
Nov 2008	37	21	19
Dec 2008	44	22	16
Total 2008	478	322	291
Jan 2009	51	32	18
Feb 2009	57	24	31
Mar 2009	34	36	22
Apr 2009	39	19	41
May 2009	51	32	26
Jun 2009	44	17	21
Jul 2009	34	19	24
Aug 2009	21	20	13
Sep 2009	32	27	19
Oct 2009	52	20	45
Nov 2009	45	26	33
Dec 2009	30	29	26
Total 2009	490	301	319
Jan 2010	40	31	27
Feb 2010	29	20	14
Mar 2010	37	37	27
Apr 2010	41	30	26
May 2010	31	48	32
Jun 2010	35	37	21
Jul 2010	29	32	21
Aug 2010	28	26	20
Sep 2010	31	50	15
Oct 2010	36	73	39
Nov 2010	49	68	55
Dec 2010	20	41	22
Total 2010	406	493	319
Jan 2011	22	46	22
Feb 2011	11	53	16
Mar 2011	34	56	35
Apr 2011	31	36	22
May 2011	26	39	29
Jun 2011	21	18	23
Jul 2011	22	26	18
Aug 2011	29	32	26
Sep 2011	36	51	29
Oct 2011	69	54	45
Nov 2011	43	90	48
Dec 2011	23	24	18
Total 2011	367	525	331
Jan 2012	37	30	18
Feb 2012	29	47	36
Mar 2012	36	34	26
Apr 2012	34	46	31
May 2012	31	37	24
Jun 2012	40	27	19
Jul 2012	23	31	17
Aug 2012	17	21	26
Sep 2012	35	30	25
Oct 2012	26	28	30
Nov 2012	28	30	24
Dec 2012	32	17	27
Total 2012	368	378	303
Jan 2013	32	21	38
Feb 2013	31	25	50
Mar 2013	31	22	27
Apr 2013	55	26	33
May 2013	27	30	25
Jun 2013	18	7	22
Jul 2013	34	13	25
Aug 2013	34	21	40
Sep 2013	24	18	34
Oct 2013	39	32	42
Nov 2013	41	24	41
Dec 2013	34	21	35
Total 2013	400	260	412
Jan 2014	22	12	39
Feb 2014	23	51	29
Mar 2014	46	57	55
Apr 2014	40	70	51
May 2014	31	40	32
Jun 2014	30	20	18
Jul 2014	37	29	15
Aug 2014	44	47	17
Sep 2014	47	88	18
Oct 2014	61	73	16
Nov 2014	32	63	13
Dec 2014	40	30	16
Total 2014	453	580	319
Jan 2015	54	39	20
Feb 2015	28	81	19
Mar 2015	35	38	31
Apr 2015	23	27	23
May 2015	22	33	16
Jun 2015	29	24	19
Jul 2015	17	27	13
Aug 2015	30	21	13
Sep 2015	36	58	20
Oct 2015	28	47	14
Nov 2015	28	44	15
Dec 2015	25	24	22
Total 2015	355	463	225
Jan 2016	49	51	23
Feb 2016	32	58	21
Mar 2016	67	34	16
Apr 2016	27	27	10
May 2016	14	31	13
Jun 2016	85	13	10
Jul 2016	46	27	18
Aug 2016	34	24	9
Sep 2016	32	37	13
Oct 2016	116	65	10
Nov 2016	54	51	12
Dec 2016	112	43	14
Total 2016	668	461	169
Jan 2017	65	98	10
Feb 2017	62	53	18
Mar 2017	45	53	13
Apr 2017	120	77	19
May 2017	31	40	15
Jun 2017	56	19	7
Jul 2017	25	42	6
Aug 2017	23	37	5
Sep 2017	45	59	6
Oct 2017	63	44	8
Nov 2017	70	54	38
Dec 2017	65	72	29
Total 2017	670	648	174
Jan 2018	55	88	23
Feb 2018	38	66	16
Mar 2018	98	101	32
Apr 2018	117	111	25
May 2018	103	104	28
Jun 2018	64	52	24
Jul 2018	84	71	32
Aug 2018	77	66	41
Sep 2018	132	107	48
Oct 2018	47	101	34
Nov 2018	39	129	48
Dec 2018	55	94	50
Total 2018	909	1090	401
Jan 2019	43	99	46
Feb 2019	42	116	43
Mar 2019	39	124	35
Apr 2019	38	147	33
May 2019	37	118	38
Jun 2019	47	95	55
Jul 2019	38	107	37
Aug 2019	38	99	48
Sep 2019	33	84	32
Oct 2019	51	115	43
Nov 2019	23	41	16
Total 2019	429	1145	426
Total	9559	13284	7846