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Research Article

Prevolutionary dynamics and the origin of evolution

Martin A. Nowak and Hisashi Ohtsuki
  1. Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Department of Mathematics, Harvard University, Cambridge, MA 02138

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PNAS first published September 12, 2008; https://doi.org/10.1073/pnas.0806714105
Martin A. Nowak
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  • For correspondence: martin_nowak@harvard.edu
Hisashi Ohtsuki
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  1. Communicated by Clifford H. Taubes, Harvard University, Cambridge, MA, July 14, 2008 (received for review May 31, 2008)

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Abstract

Life is that which replicates and evolves. The origin of life is also the origin of evolution. A fundamental question is when do chemical kinetics become evolutionary dynamics? Here, we formulate a general mathematical theory for the origin of evolution. All known life on earth is based on biological polymers, which act as information carriers and catalysts. Therefore, any theory for the origin of life must address the emergence of such a system. We describe prelife as an alphabet of active monomers that form random polymers. Prelife is a generative system that can produce information. Prevolutionary dynamics have selection and mutation, but no replication. Life marches in with the ability of replication: Polymers act as templates for their own reproduction. Prelife is a scaffold that builds life. Yet, there is competition between life and prelife. There is a phase transition: If the effective replication rate exceeds a critical value, then life outcompetes prelife. Replication is not a prerequisite for selection, but instead, there can be selection for replication. Mutation leads to an error threshold between life and prelife.

  • prelife
  • replication
  • selection
  • mutation
  • mathematical biology

Footnotes

  • †To whom correspondence should be addressed. E-mail: martin_nowak{at}harvard.edu
  • Author contributions: M.A.N. and H.O. wrote the paper.

  • The authors declare no conflict of interest.

  • © 2008 by The National Academy of Sciences of the USA
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Prevolutionary dynamics and the origin of evolution
Martin A. Nowak, Hisashi Ohtsuki
Proceedings of the National Academy of Sciences Sep 2008, DOI: 10.1073/pnas.0806714105

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Prevolutionary dynamics and the origin of evolution
Martin A. Nowak, Hisashi Ohtsuki
Proceedings of the National Academy of Sciences Sep 2008, DOI: 10.1073/pnas.0806714105
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