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Research Article

Genetic identification of putative remains of the famous astronomer Nicolaus Copernicus

Wiesław Bogdanowicz, Marie Allen, Wojciech Branicki, Maria Lembring, Marta Gajewska, and Tomasz Kupiec
  1. aMuseum and Institute of Zoology, Polish Academy of Sciences, Wilcza 64, 00-679, Warszawa, Poland;
  2. bDepartment of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden; and
  3. cSection of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31-033, Kraków, Poland

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PNAS first published July 7, 2009; https://doi.org/10.1073/pnas.0901848106
Wiesław Bogdanowicz
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  • For correspondence: wieslawb@miiz.waw.pl marie.allen@genpat.uu.se wbranicki@ies.krakow.pl
Marie Allen
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  • For correspondence: wieslawb@miiz.waw.pl marie.allen@genpat.uu.se wbranicki@ies.krakow.pl
Wojciech Branicki
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  • For correspondence: wieslawb@miiz.waw.pl marie.allen@genpat.uu.se wbranicki@ies.krakow.pl
Maria Lembring
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Marta Gajewska
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Tomasz Kupiec
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  1. ↵1W. Bogdanowicz, M.A., and W. Branicki contributed equally to this work.

  2. Edited by Alan Walker, Pennsylvania State University, University Park, PA, and approved June 16, 2009 (received for review February 18, 2009)

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Abstract

We report the results of mitochondrial and nuclear DNA analyses of skeletal remains exhumed in 2005 at Frombork Cathedral in Poland, that are thought to be those of Nicolaus Copernicus (1473–1543). The analyzed bone remains were found close to the altar Nicolaus Copernicus was responsible for during his tenure as priest. The mitochondrial DNA (mtDNA) profiles from 3 upper molars and the femurs were identical, suggesting that the remains originate from the same individual. Identical mtDNA profiles were also determined in 2 hairs discovered in a calendar now exhibited at Museum Gustavianum in Uppsala, Sweden. This calendar was the property of Nicolaus Copernicus for much of his life. These findings, together with anthropological data, support the identification of the human remains found in Frombork Cathedral as those of Nicolaus Copernicus. Up-to-now the particular mtDNA haplotype has been observed only 3 times in Germany and once in Denmark. Moreover, Y-chromosomal and autosomal short tandem repeat markers were analyzed in one of the tooth samples, that was much better preserved than other parts of the skeleton. Molecular sex determination revealed that the skeleton is from a male individual, and this result is consistent with morphological investigations. The minimal Y-chromosomal haplotype determined in the putative remains of Nicolaus Copernicus has been observed previously in many countries, including Austria, Germany, Poland, and the Czech Republic. Finally, an analysis of the SNP located in the HERC2 gene revealed the C/C genotype that is predominant in blue-eyed humans, suggesting that Copernicus may have had a light iris color.

  • eye-color marker
  • hairs
  • human remains
  • identification
  • mitochondrial and nuclear DNA

Footnotes

  • 2To whom correspondence may be addressed. E-mail: wieslawb{at}miiz.waw.pl, marie.allen{at}genpat.uu.se, or wbranicki{at}ies.krakow.pl
  • Author contributions: W. Bogdanowicz, M.A., and W. Branicki designed research; W. Bogdanowicz, M.A., W. Branicki, M.L., M.G., and T.K. performed research; W. Bogdano- wicz, M.A., W. Branicki, M.L., M.G., and T.K. analyzed data; and W. Bogdanowicz, M.A., W. Branicki, and M.G. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

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Genetic identification of putative remains of the famous astronomer Nicolaus Copernicus
Wiesław Bogdanowicz, Marie Allen, Wojciech Branicki, Maria Lembring, Marta Gajewska, Tomasz Kupiec
Proceedings of the National Academy of Sciences Jul 2009, pnas.0901848106; DOI: 10.1073/pnas.0901848106

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Genetic identification of putative remains of the famous astronomer Nicolaus Copernicus
Wiesław Bogdanowicz, Marie Allen, Wojciech Branicki, Maria Lembring, Marta Gajewska, Tomasz Kupiec
Proceedings of the National Academy of Sciences Jul 2009, pnas.0901848106; DOI: 10.1073/pnas.0901848106
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