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Research Article

Running enhances spatial pattern separation in mice

David J. Creer, Carola Romberg, Lisa M. Saksida, Henriette van Praag, and Timothy J. Bussey
  1. aLaboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224;
  2. bDepartment of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom; and
  3. cMedical Research Council and Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom

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PNAS first published January 19, 2010; https://doi.org/10.1073/pnas.0911725107
David J. Creer
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Carola Romberg
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Lisa M. Saksida
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Henriette van Praag
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  • For correspondence: vanpraagh@mail.nih.gov
Timothy J. Bussey
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Abstract

Increasing evidence suggests that regular exercise improves brain health and promotes synaptic plasticity and hippocampal neurogenesis. Exercise improves learning, but specific mechanisms of information processing influenced by physical activity are unknown. Here, we report that voluntary running enhanced the ability of adult (3 months old) male C57BL/6 mice to discriminate between the locations of two adjacent identical stimuli. Improved spatial pattern separation in adult runners was tightly correlated with increased neurogenesis. In contrast, very aged (22 months old) mice had impaired spatial discrimination and low basal cell genesis that was refractory to running. These findings suggest that the addition of newly born neurons may bolster dentate gyrus-mediated encoding of fine spatial distinctions.

  • exercise
  • hippocampus
  • learning
  • neurogenesis
  • pattern separation

Footnotes

  • 1To whom correspondence should be addressed at: Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224. E-mail: vanpraagh{at}mail.nih.gov.
  • Edited* by Ivan Izquierdo, Memory Center, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil, and approved December 18, 2009 (received for review October 11, 2009)

  • Author contributions: L.M.S., H.v.P., and T.J.B. designed research; D.J.C., C.R., and H.v.P. performed research; D.J.C., C.R., and H.v.P. analyzed data; and H.v.P. wrote the paper.

  • *This Direct Submission article had a prearranged editor.

  • The authors declare no conflict of interest.

  • This article contains supporting information online at www.pnas.org/cgi/content/full/0911725107/DCSupplemental.

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Running enhances spatial pattern separation in mice
David J. Creer, Carola Romberg, Lisa M. Saksida, Henriette van Praag, Timothy J. Bussey
Proceedings of the National Academy of Sciences Jan 2010, 200911725; DOI: 10.1073/pnas.0911725107

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Running enhances spatial pattern separation in mice
David J. Creer, Carola Romberg, Lisa M. Saksida, Henriette van Praag, Timothy J. Bussey
Proceedings of the National Academy of Sciences Jan 2010, 200911725; DOI: 10.1073/pnas.0911725107
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