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Biological Sciences

Genomic and physiological footprint of the Deepwater Horizon oil spill on resident marsh fishes

Andrew Whitehead, Benjamin Dubansky, Charlotte Bodinier, Tzintzuni I. Garcia, Scott Miles, Chet Pilley, Vandana Raghunathan, Jennifer L. Roach, Nan Walker, Ronald B. Walter, Charles D. Rice, and Fernando Galvez
  1. Departments of aBiological Sciences,
  2. cEnvironmental Sciences, and
  3. eOceanography and Coastal Sciences, and
  4. dCoastal Studies Institute, Louisiana State University, Baton Rouge, LA 70803;
  5. bDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666; and
  6. fDepartment of Biological Sciences, Clemson University, Clemson, SC 29634

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PNAS first published September 26, 2011; https://doi.org/10.1073/pnas.1109545108
Andrew Whitehead
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  • For correspondence: andreww@lsu.edu
Benjamin Dubansky
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Charlotte Bodinier
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Tzintzuni I. Garcia
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Scott Miles
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Chet Pilley
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Vandana Raghunathan
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Jennifer L. Roach
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Nan Walker
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Ronald B. Walter
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Charles D. Rice
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Fernando Galvez
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  1. Edited by Paul G. Falkowski, Rutgers, The State University of New Jersey, New Brunswick, NJ, and approved September 1, 2011 (received for review June 13, 2011)

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Abstract

The biological consequences of the Deepwater Horizon oil spill are unknown, especially for resident organisms. Here, we report results from a field study tracking the effects of contaminating oil across space and time in resident killifish during the first 4 mo of the spill event. Remote sensing and analytical chemistry identified exposures, which were linked to effects in fish characterized by genome expression and associated gill immunohistochemistry, despite very low concentrations of hydrocarbons remaining in water and tissues. Divergence in genome expression coincides with contaminating oil and is consistent with genome responses that are predictive of exposure to hydrocarbon-like chemicals and indicative of physiological and reproductive impairment. Oil-contaminated waters are also associated with aberrant protein expression in gill tissues of larval and adult fish. These data suggest that heavily weathered crude oil from the spill imparts significant biological impacts in sensitive Louisiana marshes, some of which remain for over 2 mo following initial exposures.

  • ecological genomics
  • ecotoxicology
  • microarray
  • RNA-seq
  • toxicogenomics

Footnotes

  • ↵1To whom correspondence should be addressed. E-mail: andreww{at}lsu.edu.
  • Author contributions: A.W. and F.G. designed research; A.W., B.D., C.B., T.I.G., S.M., C.P., V.R., J.L.R., N.W., R.B.W. and F.G. performed research; C.D.R. contributed new reagents/analytic tools; A.W., B.D., C.B., T.I.G., S.M., C.P., V.R., N.W., R.B.W. and F.G. analyzed data; and A.W., B.D., C.B., and F.G. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • Data deposition: Microarray data have been deposited to ArrayExpress (accession no. E-MTAB-663).

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1109545108/-/DCSupplemental.

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Genomic and physiological footprint of the Deepwater Horizon oil spill on resident marsh fishes
Andrew Whitehead, Benjamin Dubansky, Charlotte Bodinier, Tzintzuni I. Garcia, Scott Miles, Chet Pilley, Vandana Raghunathan, Jennifer L. Roach, Nan Walker, Ronald B. Walter, Charles D. Rice, Fernando Galvez
Proceedings of the National Academy of Sciences Sep 2011, 201109545; DOI: 10.1073/pnas.1109545108

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Genomic and physiological footprint of the Deepwater Horizon oil spill on resident marsh fishes
Andrew Whitehead, Benjamin Dubansky, Charlotte Bodinier, Tzintzuni I. Garcia, Scott Miles, Chet Pilley, Vandana Raghunathan, Jennifer L. Roach, Nan Walker, Ronald B. Walter, Charles D. Rice, Fernando Galvez
Proceedings of the National Academy of Sciences Sep 2011, 201109545; DOI: 10.1073/pnas.1109545108
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