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Research Article

Orthogonal acoustic dimensions define auditory field maps in human cortex

Brian Barton, Jonathan H. Venezia, Kourosh Saberi, Gregory Hickok, and Alyssa A. Brewer
  1. aCenter for Cognitive Neuroscience and Department of Cognitive Sciences, and
  2. bCenter for Language Science and Center for Hearing Research, University of California, Irvine, CA 92697

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PNAS first published November 27, 2012; https://doi.org/10.1073/pnas.1213381109
Brian Barton
aCenter for Cognitive Neuroscience and Department of Cognitive Sciences, and
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Jonathan H. Venezia
aCenter for Cognitive Neuroscience and Department of Cognitive Sciences, and
bCenter for Language Science and Center for Hearing Research, University of California, Irvine, CA 92697
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Kourosh Saberi
aCenter for Cognitive Neuroscience and Department of Cognitive Sciences, and
bCenter for Language Science and Center for Hearing Research, University of California, Irvine, CA 92697
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Gregory Hickok
aCenter for Cognitive Neuroscience and Department of Cognitive Sciences, and
bCenter for Language Science and Center for Hearing Research, University of California, Irvine, CA 92697
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Alyssa A. Brewer
aCenter for Cognitive Neuroscience and Department of Cognitive Sciences, and
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  • For correspondence: aabrewer@uci.edu
  1. Edited* by George Sperling, University of California, Irvine, CA, and approved November 1, 2012 (received for review August 16, 2012)

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Abstract

The functional organization of human auditory cortex has not yet been characterized beyond a rudimentary level of detail. Here, we use functional MRI to measure the microstructure of orthogonal tonotopic and periodotopic gradients forming complete auditory field maps (AFMs) in human core and belt auditory cortex. These AFMs show clear homologies to subfields of auditory cortex identified in nonhuman primates and in human cytoarchitectural studies. In addition, we present measurements of the macrostructural organization of these AFMs into “clover leaf” clusters, consistent with the macrostructural organization seen across human visual cortex. As auditory cortex is at the interface between peripheral hearing and central processes, improved understanding of the organization of this system could open the door to a better understanding of the transformation from auditory spectrotemporal signals to higher-order information such as speech categories.

  • tonotopy
  • periodotopy
  • cochleotopy
  • temporal receptive field
  • traveling wave

Footnotes

  • ↵1To whom correspondence should be addressed. E-mail: aabrewer{at}uci.edu.
  • Author contributions: B.B., J.H.V., K.S., G.H., and A.A.B. designed research; B.B. and J.H.V. performed research; B.B. and A.A.B. analyzed data; and B.B. wrote the paper.

  • The authors declare no conflict of interest.

  • ↵*This Direct Submission article had a prearranged editor.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1213381109/-/DCSupplemental.

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Auditory field maps in human cortex
Brian Barton, Jonathan H. Venezia, Kourosh Saberi, Gregory Hickok, Alyssa A. Brewer
Proceedings of the National Academy of Sciences Nov 2012, 201213381; DOI: 10.1073/pnas.1213381109

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Auditory field maps in human cortex
Brian Barton, Jonathan H. Venezia, Kourosh Saberi, Gregory Hickok, Alyssa A. Brewer
Proceedings of the National Academy of Sciences Nov 2012, 201213381; DOI: 10.1073/pnas.1213381109
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