Surge of neurophysiological coherence and connectivity in the dying brain

Jimo Borjigin, UnCheol Lee, Tiecheng Liu, Dinesh Pal, Sean Huff, Daniel Klarr, Jennifer Sloboda, Jason Hernandez, Michael M. Wang, and George A. Mashour
PNAS published ahead of print August 12, 2013 https://doi.org/10.1073/pnas.1308285110

  1. Edited by Solomon H. Snyder, The Johns Hopkins University School of Medicine, Baltimore, MD, and approved July 9, 2013 (received for review May 2, 2013)

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Abstract

The brain is assumed to be hypoactive during cardiac arrest. However, the neurophysiological state of the brain immediately following cardiac arrest has not been systematically investigated. In this study, we performed continuous electroencephalography in rats undergoing experimental cardiac arrest and analyzed changes in power density, coherence, directed connectivity, and cross-frequency coupling. We identified a transient surge of synchronous gamma oscillations that occurred within the first 30 s after cardiac arrest and preceded isoelectric electroencephalogram. Gamma oscillations during cardiac arrest were global and highly coherent; moreover, this frequency band exhibited a striking increase in anterior–posterior-directed connectivity and tight phase-coupling to both theta and alpha waves. High-frequency neurophysiological activity in the near-death state exceeded levels found during the conscious waking state. These data demonstrate that the mammalian brain can, albeit paradoxically, generate neural correlates of heightened conscious processing at near-death.

Footnotes

  • ↵1J.B. and U.L. contributed equally to this work.

  • ↵2To whom correspondence should be addressed. E-mail: borjigin{at}umich.edu.

  • Author contributions: J.B. and M.M.W. conceived the idea of the project; J.B. and G.A.M. designed experiments; J.B., U.L., and G.A.M. planned analysis; T.L. and D.P. performed electrode implantation; J.B., T.L., D.P., S.H., and D.K. collected data; U.L. wrote analysis programs; J.B., U.L., J.S., J.H., and G.A.M. analyzed data; and J.B., U.L., M.M.W., and G.A.M. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1308285110/-/DCSupplemental.

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Brain activity surges at near-death
Jimo Borjigin, UnCheol Lee, Tiecheng Liu, Dinesh Pal, Sean Huff, Daniel Klarr, Jennifer Sloboda, Jason Hernandez, Michael M. Wang, George A. Mashour
Proceedings of the National Academy of Sciences Aug 2013, 201308285; DOI: 10.1073/pnas.1308285110
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