Edited by Christopher B. Ruff, The Johns Hopkins University School of Medicine, Baltimore, MD, and accepted by the Editorial Board February 21, 2014 (received for review November 22, 2013)
Bones adapt to mechanical forces in youth to increase their size and strength but are more at risk for breaking later in life. Do the skeletal benefits of physical activity in youth persist with aging? Here we show at an upper extremity site that half of the benefit in bone size and one-third of the benefit in bone strength obtained from physical activity during youth are maintained throughout life, even though the bone mass benefits are lost. When physical activity was continued during aging, some mass and more strength benefits were preserved. These data suggest that physical activity during youth should be encouraged for lifelong bone health, with the focus being optimization of bone size rather than increasing mass.
The skeleton shows greatest plasticity to physical activity-related mechanical loads during youth but is more at risk for failure during aging. Do the skeletal benefits of physical activity during youth persist with aging? To address this question, we used a uniquely controlled cross-sectional study design in which we compared the throwing-to-nonthrowing arm differences in humeral diaphysis bone properties in professional baseball players at different stages of their careers (n = 103) with dominant-to-nondominant arm differences in controls (n = 94). Throwing-related physical activity introduced extreme loading to the humeral diaphysis and nearly doubled its strength. Once throwing activities ceased, the cortical bone mass, area, and thickness benefits of physical activity during youth were gradually lost because of greater medullary expansion and cortical trabecularization. However, half of the bone size (total cross-sectional area) and one-third of the bone strength (polar moment of inertia) benefits of throwing-related physical activity during youth were maintained lifelong. In players who continued throwing during aging, some cortical bone mass and more strength benefits of the physical activity during youth were maintained as a result of less medullary expansion and cortical trabecularization. These data indicate that the old adage of “use it or lose it” is not entirely applicable to the skeleton and that physical activity during youth should be encouraged for lifelong bone health, with the focus being optimization of bone size and strength rather than the current paradigm of increasing mass. The data also indicate that physical activity should be encouraged during aging to reduce skeletal structural decay.
Author contributions: S.J.W., M.E.K., M.G.P., and R.K.F. designed research; S.J.W., S.M.M.R., M.E.K., A.L.H., G.S.F., M.G.P., and R.K.F. performed research; S.J.W., S.M.M.R., M.E.K., M.G.P., and R.K.F. analyzed data; and S.J.W., M.E.K., M.G.P., and R.K.F. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission. C.B.R. is a guest editor invited by the Editorial Board.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1321605111/-/DCSupplemental.
