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Research Article

Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome

Laurent Chatre, Denis S. F. Biard, Alain Sarasin, and Miria Ricchetti
PNAS first published May 18, 2015; https://doi.org/10.1073/pnas.1422264112
Laurent Chatre
aInstitut Pasteur, Department of Genomes and Genetics, Unité de Génétique Moléculaire des Levures, 75724 Paris, France;
bCNRS UMR 3525, Team Stability of Nuclear and Mitochondrial DNA,
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Denis S. F. Biard
cCommissariat à l'Énergie Atomique et aux Énergies Alternatives, Institute of Emerging Diseases and Innovative Therapies (iMETI), Division of Prions and Related Diseases (SEPIA), Team Cellular Engineering and Human Syndromes, F-92265 Fontenay-aux-Roses, France;
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Alain Sarasin
dUMR 8200 CNRS Laboratory of Genetic Stability and Oncogenesis, Institut de cancérologie Gustave Roussy, and University Paris-Sud, 114 rue Edouard Vaillant, 94805 Villejuif, France; and
eDepartment of Genetics, Institut de Cancérologie Gustave Roussy, 94805 Villejuif, France
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Miria Ricchetti
aInstitut Pasteur, Department of Genomes and Genetics, Unité de Génétique Moléculaire des Levures, 75724 Paris, France;
bCNRS UMR 3525, Team Stability of Nuclear and Mitochondrial DNA,
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  • For correspondence: mricch@pasteur.fr
  1. Edited by Philip C. Hanawalt, Stanford University, Stanford, CA, and approved April 14, 2015 (received for review November 20, 2014)

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Protease burst depletes Polγ in premature aging
Laurent Chatre, Denis S. F. Biard, Alain Sarasin, Miria Ricchetti
Proceedings of the National Academy of Sciences May 2015, 201422264; DOI: 10.1073/pnas.1422264112

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Protease burst depletes Polγ in premature aging
Laurent Chatre, Denis S. F. Biard, Alain Sarasin, Miria Ricchetti
Proceedings of the National Academy of Sciences May 2015, 201422264; DOI: 10.1073/pnas.1422264112
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Proceedings of the National Academy of Sciences: 118 (3)
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