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Research Article

BMP9 and BMP10 are necessary for proper closure of the ductus arteriosus

Sandrine Levet, Marie Ouarné, Delphine Ciais, Charles Coutton, Mariela Subileau, Christine Mallet, Nicolas Ricard, Marie Bidart, Thierry Debillon, Francesca Faravelli, Caroline Rooryck, Jean-Jacques Feige, Emmanuelle Tillet, and Sabine Bailly
  1. aInstitut National de la santé et de la Recherche Médicale (INSERM, U1036), Grenoble, France F-38000;
  2. bCommissariat à l’Énergie Atomique et aux Energies Alternatives, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France F-38000;
  3. cUniversité Grenoble-Alpes, Grenoble, France F-38000;
  4. dLaboratoire de Génétique Chromosomique, Département de Génétique et Procréation, Hôpital Couple Enfant, Centre Hospitalier Universitaire de Grenoble, Grenoble F-38000, France;
  5. eEquipe “Génétique, Infertilité et Thérapeutique,” Laboratoire Andrologie Gérontechnologie Inflammation Modélisation, CNRS FRE3405, Grenoble, France F-38000;
  6. fService de Médecine et Réanimation Néonatale, Centre Hospitalier Universitaire de Grenoble, Grenoble, France F-38000;
  7. gDivision of Medical Genetics, Galliera Hospital, Genoa, Italy;
  8. hService de Génétique Médicale, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France F-33000

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PNAS first published June 8, 2015; https://doi.org/10.1073/pnas.1508386112
Sandrine Levet
aInstitut National de la santé et de la Recherche Médicale (INSERM, U1036), Grenoble, France F-38000;
bCommissariat à l’Énergie Atomique et aux Energies Alternatives, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France F-38000;
cUniversité Grenoble-Alpes, Grenoble, France F-38000;
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Marie Ouarné
aInstitut National de la santé et de la Recherche Médicale (INSERM, U1036), Grenoble, France F-38000;
bCommissariat à l’Énergie Atomique et aux Energies Alternatives, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France F-38000;
cUniversité Grenoble-Alpes, Grenoble, France F-38000;
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Delphine Ciais
aInstitut National de la santé et de la Recherche Médicale (INSERM, U1036), Grenoble, France F-38000;
bCommissariat à l’Énergie Atomique et aux Energies Alternatives, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France F-38000;
cUniversité Grenoble-Alpes, Grenoble, France F-38000;
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Charles Coutton
cUniversité Grenoble-Alpes, Grenoble, France F-38000;
dLaboratoire de Génétique Chromosomique, Département de Génétique et Procréation, Hôpital Couple Enfant, Centre Hospitalier Universitaire de Grenoble, Grenoble F-38000, France;
eEquipe “Génétique, Infertilité et Thérapeutique,” Laboratoire Andrologie Gérontechnologie Inflammation Modélisation, CNRS FRE3405, Grenoble, France F-38000;
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Mariela Subileau
aInstitut National de la santé et de la Recherche Médicale (INSERM, U1036), Grenoble, France F-38000;
bCommissariat à l’Énergie Atomique et aux Energies Alternatives, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France F-38000;
cUniversité Grenoble-Alpes, Grenoble, France F-38000;
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Christine Mallet
aInstitut National de la santé et de la Recherche Médicale (INSERM, U1036), Grenoble, France F-38000;
bCommissariat à l’Énergie Atomique et aux Energies Alternatives, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France F-38000;
cUniversité Grenoble-Alpes, Grenoble, France F-38000;
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Nicolas Ricard
aInstitut National de la santé et de la Recherche Médicale (INSERM, U1036), Grenoble, France F-38000;
bCommissariat à l’Énergie Atomique et aux Energies Alternatives, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France F-38000;
cUniversité Grenoble-Alpes, Grenoble, France F-38000;
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Marie Bidart
aInstitut National de la santé et de la Recherche Médicale (INSERM, U1036), Grenoble, France F-38000;
bCommissariat à l’Énergie Atomique et aux Energies Alternatives, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France F-38000;
cUniversité Grenoble-Alpes, Grenoble, France F-38000;
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Thierry Debillon
fService de Médecine et Réanimation Néonatale, Centre Hospitalier Universitaire de Grenoble, Grenoble, France F-38000;
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Francesca Faravelli
gDivision of Medical Genetics, Galliera Hospital, Genoa, Italy;
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Caroline Rooryck
hService de Génétique Médicale, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France F-33000
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Jean-Jacques Feige
aInstitut National de la santé et de la Recherche Médicale (INSERM, U1036), Grenoble, France F-38000;
bCommissariat à l’Énergie Atomique et aux Energies Alternatives, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France F-38000;
cUniversité Grenoble-Alpes, Grenoble, France F-38000;
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Emmanuelle Tillet
aInstitut National de la santé et de la Recherche Médicale (INSERM, U1036), Grenoble, France F-38000;
bCommissariat à l’Énergie Atomique et aux Energies Alternatives, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France F-38000;
cUniversité Grenoble-Alpes, Grenoble, France F-38000;
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Sabine Bailly
aInstitut National de la santé et de la Recherche Médicale (INSERM, U1036), Grenoble, France F-38000;
bCommissariat à l’Énergie Atomique et aux Energies Alternatives, Institut de Recherches en Technologies et Sciences pour le Vivant, Laboratoire Biologie du Cancer et de l'Infection, Grenoble, France F-38000;
cUniversité Grenoble-Alpes, Grenoble, France F-38000;
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  • For correspondence: sabine.bailly@cea.fr
  1. Edited by Napoleone Ferrara, University of California, San Diego, La Jolla, CA, and approved May 19, 2015 (received for review April 30, 2015)

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BMP9 and BMP10 in ductus arteriosus closure
Sandrine Levet, Marie Ouarné, Delphine Ciais, Charles Coutton, Mariela Subileau, Christine Mallet, Nicolas Ricard, Marie Bidart, Thierry Debillon, Francesca Faravelli, Caroline Rooryck, Jean-Jacques Feige, Emmanuelle Tillet, Sabine Bailly
Proceedings of the National Academy of Sciences Jun 2015, 201508386; DOI: 10.1073/pnas.1508386112

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BMP9 and BMP10 in ductus arteriosus closure
Sandrine Levet, Marie Ouarné, Delphine Ciais, Charles Coutton, Mariela Subileau, Christine Mallet, Nicolas Ricard, Marie Bidart, Thierry Debillon, Francesca Faravelli, Caroline Rooryck, Jean-Jacques Feige, Emmanuelle Tillet, Sabine Bailly
Proceedings of the National Academy of Sciences Jun 2015, 201508386; DOI: 10.1073/pnas.1508386112
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