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Research Article

Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes

Kou-San Ju, Jiangtao Gao, James R. Doroghazi, Kwo-Kwang A. Wang, Christopher J. Thibodeaux, Steven Li, Emily Metzger, John Fudala, Joleen Su, Jun Kai Zhang, Jaeheon Lee, Joel P. Cioni, Bradley S. Evans, Ryuichi Hirota, David P. Labeda, Wilfred A. van der Donk, and William W. Metcalf
PNAS first published August 31, 2015; https://doi.org/10.1073/pnas.1500873112
Kou-San Ju
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
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Jiangtao Gao
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
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James R. Doroghazi
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
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Kwo-Kwang A. Wang
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
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Christopher J. Thibodeaux
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
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Steven Li
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
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Emily Metzger
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
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John Fudala
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
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Joleen Su
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
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Jun Kai Zhang
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
bDepartment of Microbiology, University of Illinois, Urbana, IL 61801;
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Jaeheon Lee
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
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Joel P. Cioni
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
bDepartment of Microbiology, University of Illinois, Urbana, IL 61801;
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Bradley S. Evans
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
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Ryuichi Hirota
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
cDepartment of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8530, Japan;
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David P. Labeda
dBacterial Foodborne Pathogens and Mycology Research, US Department of Agriculture, Agricultural Research Service, National Center for Agricultural Utilization Research, Peoria, IL 61604;
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Wilfred A. van der Donk
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
eDepartment of Chemistry and Howard Hughes Medical Institute, University of Illinois, Urbana, IL 61081
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  • For correspondence: vddonk@illinois.edu metcalf@illinois.edu
William W. Metcalf
aCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL 61801;
bDepartment of Microbiology, University of Illinois, Urbana, IL 61801;
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  • For correspondence: vddonk@illinois.edu metcalf@illinois.edu
  1. Edited by Jerrold Meinwald, Cornell University, Ithaca, NY, and approved July 31, 2015 (received for review January 14, 2015)

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Discovery of phosphonates by genome mining
Kou-San Ju, Jiangtao Gao, James R. Doroghazi, Kwo-Kwang A. Wang, Christopher J. Thibodeaux, Steven Li, Emily Metzger, John Fudala, Joleen Su, Jun Kai Zhang, Jaeheon Lee, Joel P. Cioni, Bradley S. Evans, Ryuichi Hirota, David P. Labeda, Wilfred A. van der Donk, William W. Metcalf
Proceedings of the National Academy of Sciences Aug 2015, 201500873; DOI: 10.1073/pnas.1500873112

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Discovery of phosphonates by genome mining
Kou-San Ju, Jiangtao Gao, James R. Doroghazi, Kwo-Kwang A. Wang, Christopher J. Thibodeaux, Steven Li, Emily Metzger, John Fudala, Joleen Su, Jun Kai Zhang, Jaeheon Lee, Joel P. Cioni, Bradley S. Evans, Ryuichi Hirota, David P. Labeda, Wilfred A. van der Donk, William W. Metcalf
Proceedings of the National Academy of Sciences Aug 2015, 201500873; DOI: 10.1073/pnas.1500873112
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