High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine

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Contributed by Philippe J. Sansonetti, August 1, 2016 (sent for review February 28, 2016; reviewed by Fredrik Bäckhed, Lora V. Hooper, and Peter Turnbaugh)

201612559

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History:

^aUnité de Pathogénie Microbienne Moléculaire, INSERM Unit U1202, Institut Pasteur, 75724 Paris Cedex 15, France;
^bInstitut National de la Recherche Agronomique, UMR 1319 MICALIS, F-78350 Jouy-en-Josas, France;
^cAgroParisTech, UMR 1319 MICALIS, F-78350 Jouy-en-Josas, France;
^dINSERM UMRS 1149, Centre de Recherche sur l’inflammation, Unité de Formation et de Recherche de Medecine Paris Diderot, F-75018 Paris, France;
^ePlate-forme de Génotypage des Eucaryotes, Biomics Pole, Centre d’Innovation et Recherche Technologique, Institut Pasteur, Paris F-75015, France;
^fLee Kong Chian School of Medicine, Nanyang Technological University, Singapore;
^gInstitut des Maladies Métaboliques et Cardiovasculaires, INSERM U1048 F-31432 Toulouse, France;
^hUniversité Paul Sabatier, F-31432 Toulouse, France;
ⁱCenter for Integrative Genomics, University of Lausanne, 1015 Lausanne, Switzerland;
^jChaire de Microbiologie et Maladies Infectieuses, Collège de France, 75005 Paris, France

Contributed by Philippe J. Sansonetti, August 1, 2016 (sent for review February 28, 2016; reviewed by Fredrik Bäckhed, Lora V. Hooper, and Peter Turnbaugh)

↵¹To whom correspondence should be addressed. Email: philippe.sansonetti{at}pasteur.fr.

Author contributions: J.T., P.J.S., and T.P. designed research; J.T., C.M., J.-B.C., R.D., B.R., C.K.T., K.D., and T.P. performed research; J.T., A.S., J.-B.C., R.D., R.B., W.W., and T.P. analyzed data; and J.T., P.J.S., and T.P. wrote the paper.
Reviewers: F.B., University of Gothenburg; L.V.H., The University of Texas Southwestern; and P.T., University of California, San Francisco.
The authors declare no conflict of interest.
Data deposition: The 16S rRNA gene sequence data have been deposited into the NCBI Sequence Read Archive database, www.ncbi.nlm.nih.gov/sra (BioProject accession nos. PRJNA306818 and PRJNA340242).
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1612559113/-/DCSupplemental.