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Research Article

A peptide extension dictates IgM assembly

Dzana Pasalic, Benedikt Weber, Chiara Giannone, Tiziana Anelli, Roger Müller, Claudio Fagioli, Manuel Felkl, Christine John, Maria Francesca Mossuto, View ORCID ProfileChristian F. W. Becker, Roberto Sitia, and Johannes Buchner
PNAS first published September 27, 2017; https://doi.org/10.1073/pnas.1701797114
Dzana Pasalic
aCenter for Integrated Protein Science Munich at the Department Chemie, Technische Universität München, 85748 Garching, Germany;
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Benedikt Weber
aCenter for Integrated Protein Science Munich at the Department Chemie, Technische Universität München, 85748 Garching, Germany;
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Chiara Giannone
bDivision of Genetics and Cell Biology, Università Vita-Salute IRCCS Ospedale San Raffaele, 20132 Milano, Italy;
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Tiziana Anelli
bDivision of Genetics and Cell Biology, Università Vita-Salute IRCCS Ospedale San Raffaele, 20132 Milano, Italy;
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Roger Müller
aCenter for Integrated Protein Science Munich at the Department Chemie, Technische Universität München, 85748 Garching, Germany;
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Claudio Fagioli
bDivision of Genetics and Cell Biology, Università Vita-Salute IRCCS Ospedale San Raffaele, 20132 Milano, Italy;
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Manuel Felkl
cFakultät Chemie, Institut für Biologische Chemie, Universität Wien, 1090 Wien, Austria
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Christine John
aCenter for Integrated Protein Science Munich at the Department Chemie, Technische Universität München, 85748 Garching, Germany;
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Maria Francesca Mossuto
bDivision of Genetics and Cell Biology, Università Vita-Salute IRCCS Ospedale San Raffaele, 20132 Milano, Italy;
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Christian F. W. Becker
cFakultät Chemie, Institut für Biologische Chemie, Universität Wien, 1090 Wien, Austria
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  • ORCID record for Christian F. W. Becker
Roberto Sitia
bDivision of Genetics and Cell Biology, Università Vita-Salute IRCCS Ospedale San Raffaele, 20132 Milano, Italy;
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  • For correspondence: sitia.roberto@hsr.it johannes.buchner@tum.de
Johannes Buchner
aCenter for Integrated Protein Science Munich at the Department Chemie, Technische Universität München, 85748 Garching, Germany;
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  • For correspondence: sitia.roberto@hsr.it johannes.buchner@tum.de
  1. Edited by Linda L. Randall, University of Missouri-Columbia, Columbia, MO, and approved September 1, 2017 (received for review February 1, 2017)

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Article Information

201701797
DOI: 
https://doi.org/10.1073/pnas.1701797114
PubMed: 
28973899

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published September 27, 2017.

Copyright & Usage: 

Author Information

  1. Dzana Pasalica,
  2. Benedikt Webera,
  3. Chiara Giannoneb,
  4. Tiziana Anellib,
  5. Roger Müllera,1,
  6. Claudio Fagiolib,
  7. Manuel Felklc,
  8. Christine Johna,
  9. Maria Francesca Mossutob,
  10. Christian F. W. Beckerc,
  11. Roberto Sitiab,2, and
  12. Johannes Buchnera,2
  1. aCenter for Integrated Protein Science Munich at the Department Chemie, Technische Universität München, 85748 Garching, Germany;
  2. bDivision of Genetics and Cell Biology, Università Vita-Salute IRCCS Ospedale San Raffaele, 20132 Milano, Italy;
  3. cFakultät Chemie, Institut für Biologische Chemie, Universität Wien, 1090 Wien, Austria
  1. Edited by Linda L. Randall, University of Missouri-Columbia, Columbia, MO, and approved September 1, 2017 (received for review February 1, 2017)

Footnotes

  • ↵1Present address: Interaction Analytics, Protein Sciences & CMC Department, Morphosys AG, 82152 Planegg, Germany.

  • ↵2To whom correspondence may be addressed. Email: sitia.roberto{at}hsr.it or johannes.buchner{at}tum.de.
  • Author contributions: D.P., R.M., C.F.W.B., R.S., and J.B. designed research; D.P., B.W., C.G., T.A., R.M., C.F., M.F., C.J., and M.F.M. performed research; D.P., B.W., and C.G. analyzed data; and D.P., B.W., T.A., R.S., and J.B. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1701797114/-/DCSupplemental.

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Article usage

Article usage: September 2017 to February 2021

AbstractFullPdf
Sep 201716483275
Oct 20175795124240
Nov 201710913335
Dec 20176662422
Total 20179200213372
Jan 20184751615
Feb 2018424149
Mar 2018982917
Apr 2018834626
May 2018514620
Jun 2018494921
Jul 2018563113
Aug 2018615213
Sep 201842398
Oct 201866010
Nov 20181508
Dec 201875015
Total 20181353482175
Jan 201934815
Feb 201944514
Mar 201946621
Apr 201926511
May 201955116
Jun 201924718
Jul 201935427
Aug 201937325
Sep 201934418
Oct 201947720
Nov 201935216
Dec 201933914
Total 201939661215
Jan 20203508
Feb 202094822
Mar 202027342
Apr 202025022
May 202055025
Jun 20202436
Jul 202053111
Aug 202022310
Sep 202066112
Oct 2020117631
Nov 2020124111
Dec 2020114513
Total 202070591213
Jan 202125112
Feb 202182921
Total 2021108033
Total1067220271008
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Peptide extension dictates IgM assembly
Dzana Pasalic, Benedikt Weber, Chiara Giannone, Tiziana Anelli, Roger Müller, Claudio Fagioli, Manuel Felkl, Christine John, Maria Francesca Mossuto, Christian F. W. Becker, Roberto Sitia, Johannes Buchner
Proceedings of the National Academy of Sciences Sep 2017, 201701797; DOI: 10.1073/pnas.1701797114

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Peptide extension dictates IgM assembly
Dzana Pasalic, Benedikt Weber, Chiara Giannone, Tiziana Anelli, Roger Müller, Claudio Fagioli, Manuel Felkl, Christine John, Maria Francesca Mossuto, Christian F. W. Becker, Roberto Sitia, Johannes Buchner
Proceedings of the National Academy of Sciences Sep 2017, 201701797; DOI: 10.1073/pnas.1701797114
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