Fig. 6. TβR-dependent transcriptome changes in “housekeeping” genes, genes of unknown function, or those not discussed in the main text. MHC genes were excluded because of the mixed H-2b/d background of the mice (25% H-2d, 75% H-2b). Notable is the suppression of genes encoding subunits of the proteasome, which indicates inhibition of regulatory proteolytic activity within the cell. Mean expression differences of TβR-modulated genes with reproducibly ³ 2-fold differences in three of four (freshly isolated cells) or four of five (stimulated cells) comparisons are shown.