Table 5. Genes and pathways that potentially relate to the environmental physiology of B. pseudomallei that are variant in B. mallei

B. mallei pathways affected

B. pseudomallei genes (Locus ID)

Glycerol

Glycerate kinase 1 (BPSS0127)

Glycerate

D-3-phosphoglycerate dehydrogenase (BPSL1250)

4 Carbon beta hydroxyacids

Hydroxypyruvate isomerase (BPSL1451)

Alpha-ketoglutaric acid

2-hydroxy-3-oxopropionate reductase (BPSL1450)

Succinate-semialdehyde dehydrogenase [NADP+] (BPSL1654)

Ribose transport and metabolism

Putative ribose transporters (BPSL1832, BPSL1833, BPSL1834, BPSS0256)

Putative ribokinase (BPSS0853, BPSL1830)

Amino acid metabolism

Alanine racemase, catabolic (BPSS0711)

Putative arginosuccinate lyase/synthase (BPSL17220, BPSL1721)

L-asparaginase (BPSS2060)

Putative cysteine synthase (BPSL1716)

Putative glutamine synthetase (BPSS0469)

Putative glutamine amidotransferase (BPSS0470)

Phenylacetic acid degradation protein PaaI (BPSL3044)

Putative serine dehydratase (BPSS1370, BPSS2116)

Putative threonine aldolase (BPSL1714)

Nitrate metabolism

Putative nitrate/nitrite tranporter (BPSS1154)

Putative respiratory nitrate reductase subunit (BPSS1156, BPSS1157, BPSS1158, BPSS1159)

Tagatose metabolism

Putative tagatose 6-phosphate kinase (BPSL0828)

Allantoin metabolism

Putative allantoinase (BPSL1681)

Cellobiose metabolism

Putative b -glucosidase, partial (BPSL1023)

These gene disruption events have most likely happened during the transition from residing in soil, to mammalian host adaption of B. mallei. See also Table 4.