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Trajectories of the ribosome as a Brownian nanomachine
Ali Dashti, Peter Schwander, Robert Langlois, Russell Fung, Wen Li, Ahmad Hosseinizadeh, Hstau Y. Liao, Jesper Pallesen, Gyanesh Sharma, Vera A. Stupina, Anne E. Simon, Jonathan D. Dinman, Joachim Frank, and Abbas Ourmazd
Ali Dashti
aDepartment of Physics, University of Wisconsin, Milwaukee, WI 53211;
Peter Schwander
aDepartment of Physics, University of Wisconsin, Milwaukee, WI 53211;
Robert Langlois
bDepartment of Biochemistry and Molecular Biophysics, and
Russell Fung
aDepartment of Physics, University of Wisconsin, Milwaukee, WI 53211;
Wen Li
bDepartment of Biochemistry and Molecular Biophysics, and
Ahmad Hosseinizadeh
aDepartment of Physics, University of Wisconsin, Milwaukee, WI 53211;
Hstau Y. Liao
bDepartment of Biochemistry and Molecular Biophysics, and
Jesper Pallesen
cHoward Hughes Medical Institute, Columbia University, New York, NY 10032; and
Gyanesh Sharma
bDepartment of Biochemistry and Molecular Biophysics, and
Vera A. Stupina
dDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742
Anne E. Simon
dDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742
Jonathan D. Dinman
dDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742
Joachim Frank
bDepartment of Biochemistry and Molecular Biophysics, andcHoward Hughes Medical Institute, Columbia University, New York, NY 10032; and
Abbas Ourmazd
aDepartment of Physics, University of Wisconsin, Milwaukee, WI 53211;
Supporting Information
Files in this Data Supplement:
- Download Supporting Information (PDF)
- Download Movie_S01 (AVI) - Movie S1. Changes in reconstructed cryo-EM snapshots from a selected viewing direction, as the path of lowest energy is traversed. The position along the path is indicated by the purple dot in the right panel.
- Download Movie_S02 (AVI) - Movie S2. Variations in the ribosome structure along the path of lowest energy, as indicated by the position of the purple dot in the right panel. The sequence of 3D structures is identical in Movies S2 through S4, but is shown in three different standard viewing directions. Viewing direction here: from the factor-binding side.
- Download Movie_S03 (AVI) - Movie S3. Variations in the ribosome structure along the path of lowest energy, as indicated by the position of the purple dot in the right panel. The sequence of 3D structures is identical in Movies S2 through S4, but is shown in three different standard viewing directions. Viewing direction here: from the solvent side.
- Download Movie_S04 (AVI) - Movie S4. Variations in the ribosome structure along the path of lowest energy, as indicated by the position of the purple dot in the right panel. The sequence of 3D structures is identical in Movies S2 through S4, but is shown in three different standard viewing directions. Viewing direction here: from the top.
- Download Movie_S05 (AVI) - Movie S5. The ribosome structure, in three standard views, as it varies between the seven successive points along the path of lowest energy indicated by the position of the red circle in the right panel.