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Research Article

Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation

Joshua P. Johansen, Lorenzo Diaz-Mataix, Hiroki Hamanaka, Takaaki Ozawa, Edgar Ycu, Jenny Koivumaa, Ashwani Kumar, Mian Hou, Karl Deisseroth, Edward S. Boyden, and Joseph E. LeDoux
PNAS first published December 8, 2014; https://doi.org/10.1073/pnas.1421304111
Joshua P. Johansen
aLaboratory for Neural Circuitry of Memory, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan;
bDepartment of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-0198, Japan;
cCenter for Neural Science, New York University, New York, NY 10003;
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  • For correspondence: ledoux@cns.nyu.edu jjohans@brain.riken.jp
Lorenzo Diaz-Mataix
cCenter for Neural Science, New York University, New York, NY 10003;
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Hiroki Hamanaka
aLaboratory for Neural Circuitry of Memory, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan;
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Takaaki Ozawa
aLaboratory for Neural Circuitry of Memory, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan;
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Edgar Ycu
aLaboratory for Neural Circuitry of Memory, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan;
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Jenny Koivumaa
aLaboratory for Neural Circuitry of Memory, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan;
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Ashwani Kumar
aLaboratory for Neural Circuitry of Memory, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan;
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Mian Hou
cCenter for Neural Science, New York University, New York, NY 10003;
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Karl Deisseroth
dDepartment of Bioengineering, Department of Psychiatry and Behavioral Sciences, and
eHoward Hughes Medical Institute, Stanford University, Stanford, CA 94305;
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Edward S. Boyden
fMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139; and
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Joseph E. LeDoux
cCenter for Neural Science, New York University, New York, NY 10003;
gThe Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962
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  • For correspondence: ledoux@cns.nyu.edu jjohans@brain.riken.jp

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