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Research Article
Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling
Riccardo Filadi, Elisa Greotti, Gabriele Turacchio, Alberto Luini, Tullio Pozzan, and Paola Pizzo
Riccardo Filadi
aDepartment of Biomedical Sciences, University of Padua, Padua, 35121, Italy;
Elisa Greotti
aDepartment of Biomedical Sciences, University of Padua, Padua, 35121, Italy;bDepartment of Biomedical Sciences, Institute of Neuroscience (Padua Section), Italian National Research Council, Padua, 35121, Italy;
Gabriele Turacchio
cDepartment of Biomedical Sciences, Institute of Protein Biochemistry, Italian National Research Council, Naples, 80131, Italy; and
Alberto Luini
cDepartment of Biomedical Sciences, Institute of Protein Biochemistry, Italian National Research Council, Naples, 80131, Italy; and
Tullio Pozzan
aDepartment of Biomedical Sciences, University of Padua, Padua, 35121, Italy;bDepartment of Biomedical Sciences, Institute of Neuroscience (Padua Section), Italian National Research Council, Padua, 35121, Italy;dVenetian Institute of Molecular Medicine, Padua, 35121, Italy
Paola Pizzo
aDepartment of Biomedical Sciences, University of Padua, Padua, 35121, Italy;
Supporting Information
Files in this Data Supplement:
- Download Supporting Information (PDF)
- Download Movie_S01 (AVI) - Coupled ER–mitochondria dynamics in Mfn2−/− MEFs. Mfn2−/− MEF cells were transfected with mit-RFP and ER-GFP and imaged by time-lapse confocal microscopy for 5 min. Frames were taken every 30 s. The movie is shown at one frame/s. White arrows indicate regions of stable colocalization (white pixels) between ER and mitochondria during organelle’s rearrangements. (Scale bar, 10 µm.)