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Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition

Siming Zhao, Stefania Bellone, Salvatore Lopez, Durga Thakral, Carlton Schwab, Diana P. English, Jonathan Black, Emiliano Cocco, Jungmin Choi, Luca Zammataro, Federica Predolini, Elena Bonazzoli, Mark Bi, Natalia Buza, Pei Hui, Serena Wong, Maysa Abu-Khalaf, Antonella Ravaggi, Eliana Bignotti, Elisabetta Bandiera, Chiara Romani, Paola Todeschini, Renata Tassi, Laura Zanotti, Franco Odicino, Sergio Pecorelli, Carla Donzelli, Laura Ardighieri, Fabio Facchetti, Marcella Falchetti, Dan-Arin Silasi, Elena Ratner, Masoud Azodi, Peter E. Schwartz, Shrikant Mane, Roberto Angioli, Corrado Terranova, Charles Matthew Quick, Babak Edraki, Kaya Bilgüvar, Moses Lee, Murim Choi, Amy L. Stiegler, Titus J. Boggon, Joseph Schlessinger, Richard P. Lifton, and Alessandro D. Santin
PNAS published ahead of print October 10, 2016 https://doi.org/10.1073/pnas.1614120113
Siming Zhao
aDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510;bHoward Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510;
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Stefania Bellone
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Salvatore Lopez
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Durga Thakral
aDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510;bHoward Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510;
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Carlton Schwab
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Diana P. English
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Jonathan Black
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Emiliano Cocco
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Jungmin Choi
aDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510;bHoward Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510;
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Luca Zammataro
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Federica Predolini
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Elena Bonazzoli
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Mark Bi
aDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510;bHoward Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510;
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Natalia Buza
dDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510;
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Pei Hui
dDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510;
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Serena Wong
dDepartment of Pathology, Yale University School of Medicine, New Haven, CT 06510;
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Maysa Abu-Khalaf
eInternal Medicine & Oncology, Yale University School of Medicine, New Haven, CT 06510;
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Antonella Ravaggi
f“Angelo Nocivelli” Institute of Molecular Medicine, Department of Obstetrics & Gynecology, University of Brescia, 25100 Brescia, Italy;
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Eliana Bignotti
f“Angelo Nocivelli” Institute of Molecular Medicine, Department of Obstetrics & Gynecology, University of Brescia, 25100 Brescia, Italy;
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Elisabetta Bandiera
f“Angelo Nocivelli” Institute of Molecular Medicine, Department of Obstetrics & Gynecology, University of Brescia, 25100 Brescia, Italy;
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Chiara Romani
f“Angelo Nocivelli” Institute of Molecular Medicine, Department of Obstetrics & Gynecology, University of Brescia, 25100 Brescia, Italy;
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Paola Todeschini
f“Angelo Nocivelli” Institute of Molecular Medicine, Department of Obstetrics & Gynecology, University of Brescia, 25100 Brescia, Italy;
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Renata Tassi
f“Angelo Nocivelli” Institute of Molecular Medicine, Department of Obstetrics & Gynecology, University of Brescia, 25100 Brescia, Italy;
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Laura Zanotti
f“Angelo Nocivelli” Institute of Molecular Medicine, Department of Obstetrics & Gynecology, University of Brescia, 25100 Brescia, Italy;
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Franco Odicino
f“Angelo Nocivelli” Institute of Molecular Medicine, Department of Obstetrics & Gynecology, University of Brescia, 25100 Brescia, Italy;
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Sergio Pecorelli
f“Angelo Nocivelli” Institute of Molecular Medicine, Department of Obstetrics & Gynecology, University of Brescia, 25100 Brescia, Italy;
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Carla Donzelli
gDepartment of Pathology, University of Brescia, 25100 Brescia, Italy;
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Laura Ardighieri
gDepartment of Pathology, University of Brescia, 25100 Brescia, Italy;
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Fabio Facchetti
gDepartment of Pathology, University of Brescia, 25100 Brescia, Italy;
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Marcella Falchetti
gDepartment of Pathology, University of Brescia, 25100 Brescia, Italy;
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Dan-Arin Silasi
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Elena Ratner
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Masoud Azodi
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Peter E. Schwartz
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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Shrikant Mane
aDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510;bHoward Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510;
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Roberto Angioli
hDivision of Gynecologic Oncology, Universita’ Campus Bio-Medico di Roma, 00128 Rome, Italy,
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Corrado Terranova
hDivision of Gynecologic Oncology, Universita’ Campus Bio-Medico di Roma, 00128 Rome, Italy,
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Charles Matthew Quick
iDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205;
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Babak Edraki
jDivision of Gynecologic Oncology, John Muir Health Clinical Research Center, Concord, CA 94598;
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Kaya Bilgüvar
aDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510;bHoward Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510;
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Moses Lee
kDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea;
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Murim Choi
kDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea;
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Amy L. Stiegler
lDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06510;
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Titus J. Boggon
lDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06510;
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Joseph Schlessinger
lDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06510;
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Richard P. Lifton
aDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06510;bHoward Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510;mLaboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY 10065
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  • For correspondence: richard.lifton@yale.edu
Alessandro D. Santin
cDepartment of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510;
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