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Research Article
Eph-ephrin signaling modulated by polymerization and condensation of receptors
View ORCID ProfileSamuel Ojosnegros, Francesco Cutrale, Daniel Rodríguez, View ORCID ProfileJason J. Otterstrom, Chi Li Chiu, Verónica Hortigüela, Carolina Tarantino, Anna Seriola, Stephen Mieruszynski, Elena Martínez, Melike Lakadamyali, Angel Raya, and Scott E. Fraser
Samuel Ojosnegros
aBiology Division, California Institute of Technology, Pasadena, CA 91125;
bCenter of Regenerative Medicine in Barcelona, Hospital Duran i Reynals, Hospitalet de Llobregat, 08908 Barcelona, Spain;
cTranslational Imaging Center, University of Southern California, Los Angeles, CA 90089;
dDepartment of Biological Sciences, Molecular and Computational Biology Section, University of Southern California, Los Angeles, CA 90089;
Francesco Cutrale
aBiology Division, California Institute of Technology, Pasadena, CA 91125;
cTranslational Imaging Center, University of Southern California, Los Angeles, CA 90089;
dDepartment of Biological Sciences, Molecular and Computational Biology Section, University of Southern California, Los Angeles, CA 90089;
Daniel Rodríguez
aBiology Division, California Institute of Technology, Pasadena, CA 91125;
eLaboratory of Theoretical & Applied Mechanics, Department of Mechanical Engineering, Universidade Federal Fluminense, Niterói, RJ 24210-240, Brazil;
Jason J. Otterstrom
fICFO-The Institute of Photonic Sciences, The Barcelona Institute of Science and Technology, 08860 Castelldefels (Barcelona), Spain;
Chi Li Chiu
gCenter for Applied Molecular Medicine, University of Southern California, Los Angeles, CA 90033;
Verónica Hortigüela
hBiomimetic Systems for Cell Engineering Group, Institute for Bioengineering of Catalonia, 08028 Barcelona, Spain;
iBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain;
Carolina Tarantino
bCenter of Regenerative Medicine in Barcelona, Hospital Duran i Reynals, Hospitalet de Llobregat, 08908 Barcelona, Spain;
Anna Seriola
bCenter of Regenerative Medicine in Barcelona, Hospital Duran i Reynals, Hospitalet de Llobregat, 08908 Barcelona, Spain;
Stephen Mieruszynski
jEuropean Molecular Biology Laboratory Australia, Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia;
Elena Martínez
hBiomimetic Systems for Cell Engineering Group, Institute for Bioengineering of Catalonia, 08028 Barcelona, Spain;
iBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain;
kElectronics Department, University of Barcelona, 08028 Barcelona, Spain;
Melike Lakadamyali
fICFO-The Institute of Photonic Sciences, The Barcelona Institute of Science and Technology, 08860 Castelldefels (Barcelona), Spain;
Angel Raya
bCenter of Regenerative Medicine in Barcelona, Hospital Duran i Reynals, Hospitalet de Llobregat, 08908 Barcelona, Spain;
iBiomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain;
lInstitució Catalana de Recerca i Estudis Avançats, 08010 Barcelona, Spain
Scott E. Fraser
bCenter of Regenerative Medicine in Barcelona, Hospital Duran i Reynals, Hospitalet de Llobregat, 08908 Barcelona, Spain;
Supporting Information
- Download Supporting Information (PDF)
- Download Appendix (PDF)
- Download Movie_S01 (MP4) - Time-lapse movie of the oligomerization map of an HEK293T:EphB2_mRuby cell presented with a poly-l-lysine–coated surface.
- Download Movie_S02 (MP4) - Time-lapse movie of the oligomerization map of an HEK293T:EphB2_mRuby cell presented with 2 μM microprinted ephrinB1 (cell 1).
- Download Movie_S03 (MP4) - Time-lapse movie of the oligomerization map of an HEK293T:EphB2_mRuby cell presented with 2 μM microprinted ephrinB1 (cell 2).
- Download Movie_S04 (MP4) - Time-lapse movie of the oligomerization map of an HEK293T:EphB2_mRuby cell presented with 0.2 μM ephrinB1 in solution.
- Download Movie_S05 (MP4) - A 3D confocal time-lapse movie of the oligomerization of an HEK293T:EphB2_mRuby cell presented with 0.2 μM ephrinB1 in solution. The red circle highlights condensation events.
- Download Movie_S06 (MP4) - A 3D confocal time-lapse movie of the oligomerization of an HEK293T:EphB2_mRuby cell presented with 0.2 μM ephrinB1 in solution. The red circle highlights condensation events.
- Download Movie_S07 (MP4) - A 3D confocal time-lapse movie of the oligomerization of an HEK293T:EphB2_mRuby cell presented with 0.2 μM ephrinB1 in solution. The red circle highlights condensation events.