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Research Article
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
Onur Basak, Teresa G. Krieger, Mauro J. Muraro, Kay Wiebrands, Daniel E. Stange, Javier Frias-Aldeguer, Nicolas C. Rivron, Marc van de Wetering, Johan H. van Es, Alexander van Oudenaarden, Benjamin D. Simons, and Hans Clevers
Onur Basak
aHubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands;bCancer Genomics Netherlands, University Medical Center Utrecht, 3584 GC, Utrecht, The Netherlands;
Teresa G. Krieger
cThe Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom;
Mauro J. Muraro
aHubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands;bCancer Genomics Netherlands, University Medical Center Utrecht, 3584 GC, Utrecht, The Netherlands;
Kay Wiebrands
aHubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands;bCancer Genomics Netherlands, University Medical Center Utrecht, 3584 GC, Utrecht, The Netherlands;
Daniel E. Stange
aHubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands;bCancer Genomics Netherlands, University Medical Center Utrecht, 3584 GC, Utrecht, The Netherlands;
Javier Frias-Aldeguer
aHubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands;dMERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229ER, Maastricht, The Netherlands;
Nicolas C. Rivron
aHubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands;dMERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6229ER, Maastricht, The Netherlands;
Marc van de Wetering
aHubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands;bCancer Genomics Netherlands, University Medical Center Utrecht, 3584 GC, Utrecht, The Netherlands;ePrincess Máxima Centre, 3584 CT, Utrecht, The Netherlands;
Johan H. van Es
aHubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands;bCancer Genomics Netherlands, University Medical Center Utrecht, 3584 GC, Utrecht, The Netherlands;
Alexander van Oudenaarden
aHubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands;bCancer Genomics Netherlands, University Medical Center Utrecht, 3584 GC, Utrecht, The Netherlands;
Benjamin D. Simons
cThe Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom;fCavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, United Kingdom;gWellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1TN, United Kingdom
Hans Clevers
aHubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands;bCancer Genomics Netherlands, University Medical Center Utrecht, 3584 GC, Utrecht, The Netherlands;ePrincess Máxima Centre, 3584 CT, Utrecht, The Netherlands;