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BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer’s disease
Jian Bao, Min Qin, Yacoubou Abdoul Razak Mahaman, Bin Zhang, Fang Huang, Kuan Zeng, Yiyuan Xia, Dan Ke, Qun Wang, Rong Liu, Jian-Zhi Wang, Keqiang Ye, and Xiaochuan Wang
Jian Bao
aDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;
Min Qin
aDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;
Yacoubou Abdoul Razak Mahaman
aDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;
Bin Zhang
bDepartment of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;
Fang Huang
aDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;
Kuan Zeng
aDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;
Yiyuan Xia
aDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;
Dan Ke
aDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;
Qun Wang
aDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;
Rong Liu
aDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;
Jian-Zhi Wang
aDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;cCo-Innovation Center of Neuroregeneration, Nantong University, JS 226001 Nantong, China;
Keqiang Ye
dDepartment of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322
Xiaochuan Wang
aDepartment of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China;cCo-Innovation Center of Neuroregeneration, Nantong University, JS 226001 Nantong, China;