Free access

Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of major histocompatibility complex class I antigens.

December 1, 1986
83 (24) 9665-9669

Abstract

The immune defense against viral infections involves cytotoxic T lymphocytes that recognize viral products in the context of class I major histocompatibility complex (MHC) antigens. To evade such immune surveillance viruses may have evolved various strategies to manipulate the expression of class I antigens. Adenovirus 2 manufactures an early glycoprotein, E19, that binds to nascent class I antigens in the endoplasmic reticulum and impedes their transport to the cell surface. We now show that adenoviruses typical of all viral subgenera except the highly oncogenic subgenus A dramatically reduce the cell-surface expression of class I antigens. It has been shown that subgenus A viruses abolish class I antigen expression in transformed cells by reducing mRNA levels. Thus, all adenoviruses can modulate the cell-surface expression of class I antigens.

Continue Reading

Information & Authors

Information

Published in

Go to Proceedings of the National Academy of Sciences
Go to Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Vol. 83 | No. 24
December 1986
PubMed: 3467330

Classifications

    Submission history

    Published online: December 1, 1986
    Published in issue: December 1986

    Authors

    Affiliations

    Metrics & Citations

    Metrics

    Note: The article usage is presented with a three- to four-day delay and will update daily once available. Due to ths delay, usage data will not appear immediately following publication. Citation information is sourced from Crossref Cited-by service.


    Citation statements

    Altmetrics

    Citations

    If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download.

    Cited by

      Loading...

      View Options

      View options

      PDF format

      Download this article as a PDF file

      DOWNLOAD PDF

      Get Access

      Login options

      Check if you have access through your login credentials or your institution to get full access on this article.

      Personal login Institutional Login

      Recommend to a librarian

      Recommend PNAS to a Librarian

      Purchase options

      Purchase this article to get full access to it.

      Single Article Purchase

      Adenoviruses of subgenera B, C, D, and E modulate cell-surface expression of major histocompatibility complex class I antigens.
      Proceedings of the National Academy of Sciences
      • Vol. 83
      • No. 24

      Media

      Figures

      Tables

      Other

      Share

      Share

      Share article link

      Share on social media