Estimation models describe well collective decisions among three options

Cover image: Pictured is a two-photon microscopy image of a multicellular spheroid made from mouse colon carcinoma cells, with fluorescently labeled actin filaments. Kévin Alessandri et al. grew the spheroid inside a permeable hollow sphere and measured the pressure it exerted while expanding. The authors found that confinement affected cellular organization: Peripheral cells became hypermotile and attempted to invade the surrounding matrix, as suggested by the cellular projections seen in the image. The authors suggest that mechanical cues from the surrounding microenvironment could trigger cell invasion from a growing tumor, and the technology could be used to screen anticancer drugs in animal-free assays. See the article by Alessandri et al. on pages 14843–14848. Image courtesy of Vasily Gurchenkov and Kévin Alessandri.