Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice
Contributed by H. Eugene Stanley, December 31, 2014 (sent for review February 3, 2014; reviewed by Gene D. Block and Thomas Penzel)
Significance
Healthy systems are characterized by scale invariance across multiple timescales. We investigated whether loss of scale invariance that occurs with aging and disease can be counteracted by exercise, in four age groups of mice. Surprisingly, we observed that lack of exercise was detrimental not only in old but also in young mice, raising the possibility of an unforeseen role of behavioral activity for health in aged and young subjects alike. Moreover, we show that scale invariance could be restored by high levels of exercise, even in old animals. The World Health Organization has pinpointed lack of exercise and a sedentary lifestyle as a major risk factor for various diseases. Our measures may guide health programs.
Abstract
In healthy humans and other animals, behavioral activity exhibits scale invariance over multiple timescales from minutes to 24 h, whereas in aging or diseased conditions, scale invariance is usually reduced significantly. Accordingly, scale invariance can be a potential marker for health. Given compelling indications that exercise is beneficial for mental and physical health, we tested to what extent a lack of exercise affects scale invariance in young and aged animals. We studied six or more mice in each of four age groups (0.5, 1, 1.5, and 2 y) and observed an age-related deterioration of scale invariance in activity fluctuations. We found that limiting the amount of exercise, by removing the running wheels, leads to loss of scale-invariant properties in all age groups. Remarkably, in both young and old animals a lack of exercise reduced the scale invariance in activity fluctuations to the same level. We next showed that scale invariance can be restored by returning the running wheels. Exercise during the active period also improved scale invariance during the resting period, suggesting that activity during the active phase may also be beneficial for the resting phase. Finally, our data showed that exercise had a stronger influence on scale invariance than the effect of age. The data suggest that exercise is beneficial as revealed by scale-invariant parameters and that, even in young animals, a lack of exercise leads to strong deterioration in these parameters.
Acknowledgments
We thank H. Post-van Engeldorp Gastelaars for excellent technical support. This research was supported by the European Commission Grant EUCLOCK (018741) (to J.H.M.), by the Netherlands Organization for Scientific Research TOPGO Grant 818.02.016 (to J.H.M.), and by Dutch Diabetes Research Foundation Grant 2013.81.1663 (to C.P.C.). K.H. is supported by NIH Grants R00-HL102241 and P01AG009975. F.A.J.L.S. was supported in part by NIH Grants R01 HL094806 and R01 HL118601. H.E.S. thanks the National Science Foundation Cyber-Enabled Discover and Innovation program for support under Award 1125290, and NIH for support under Award 5R01AG021133.
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Published online: February 9, 2015
Published in issue: February 24, 2015
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Acknowledgments
We thank H. Post-van Engeldorp Gastelaars for excellent technical support. This research was supported by the European Commission Grant EUCLOCK (018741) (to J.H.M.), by the Netherlands Organization for Scientific Research TOPGO Grant 818.02.016 (to J.H.M.), and by Dutch Diabetes Research Foundation Grant 2013.81.1663 (to C.P.C.). K.H. is supported by NIH Grants R00-HL102241 and P01AG009975. F.A.J.L.S. was supported in part by NIH Grants R01 HL094806 and R01 HL118601. H.E.S. thanks the National Science Foundation Cyber-Enabled Discover and Innovation program for support under Award 1125290, and NIH for support under Award 5R01AG021133.
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The authors declare no conflict of interest.
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Lack of exercise leads to significant and reversible loss of scale invariance in both aged and young mice, Proc. Natl. Acad. Sci. U.S.A.
112 (8) 2320-2324,
https://doi.org/10.1073/pnas.1424706112
(2015).
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