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The primary cilium of cholinergic neurons may be a linchpin in the progression of Parkinson’s Disease

Santiago Uribe-Cano https://orcid.org/0000-0002-3075-6234 and Andreas H. Kottmann https://orcid.org/0000-0002-5435-7502 [email protected]Authors Info & Affiliations
September 17, 2024
121 (39) e2414226121
https://doi.org/10.1073/pnas.2414226121
This article has been updated
Research Article
August 1, 2024
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease
Shahzad S. Khan, Ebsy Jaimon [...] Suzanne R. Pfeffer
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Acknowledgments

S.U. was supported by grant NIH T32GM136499 (PIs Ruth Stark and Mark Steinberg) and A.H.K. was supported by NIH NS095253 and NIH U54MD017979 (PI Maria Lima).

Author contributions

S.U. and A.H.K. wrote the paper.

Competing interests

The authors declare no competing interest.

References

1
A. Barbeau, The pathogenesis of Parkinson’s disease: A new hypothesis. Can. Med. Assoc. J. 87, 802–807 (1962).
PubMed
Google Scholar
2
S. S. Khan et al., Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease. Proc. Natl. Acad. Sci. U.S.A. 121, e2402206121 (2024).
Crossref
PubMed
Google Scholar
3
J. W. McKinley et al., Dopamine deficiency reduces striatal cholinergic interneuron function in models of Parkinson’s Disease. Neuron 103, 1056–1072.e6 (2019).
Crossref
PubMed
Google Scholar
4
N. I. Bohnen, R. L. Albin, The cholinergic system and Parkinson disease. Behav. Brain Res. 221, 564–573 (2011).
Crossref
PubMed
Google Scholar
5
J. M. Taymans et al., Perspective on the current state of the LRRK2 field. NPJ Parkinsons Dis. 9, 104 (2023).
Crossref
PubMed
Google Scholar
6
P. Mill, S. T. Christensen, L. B. Pedersen, Primary cilia as dynamic and diverse signalling hubs in development and disease. Nat. Rev. Genet. 24, 421–441 (2023).
Crossref
PubMed
Google Scholar
7
W. M. Yeshaw et al., Localization of PPM1H phosphatase tunes Parkinson’s disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis. Proc. Natl. Acad. Sci. U.S.A. 120, e2315171120 (2023).
Crossref
PubMed
Google Scholar
8
N. Y. Ahmed, R. Knowles, N. Dehorter, New insights into cholinergic neuron diversity. Front. Mol. Neurosci. 12, 204 (2019).
Crossref
PubMed
Google Scholar
9
S. S. Khan et al., Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain. Elife 10, e67900 (2021).
Crossref
PubMed
Google Scholar
10
Y. Zhang, P. A. Beachy, Cellular and molecular mechanisms of Hedgehog signalling. Nat. Rev. Mol. Cell Biol. 24, 668–687 (2023).
Crossref
PubMed
Google Scholar
11
C. Ortega-de San Luis et al., Substantia nigra dopaminergic neurons and striatal interneurons are engaged in three parallel but interdependent postnatal neurotrophic circuits. Aging Cell 17, e12821 (2018).
Crossref
PubMed
Google Scholar
12
L. Malave et al., Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia. Commun. Biol. 4, 1071 (2021).
Crossref
PubMed
Google Scholar

Information & Authors

Information

Published in

Go to Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Vol. 121 | No. 39
September 24, 2024
PubMed: 39288184

Classifications

  1. Biological Sciences
  2. Medical Sciences

Copyright

Copyright © 2024 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Submission history

Published online: September 17, 2024
Published in issue: September 24, 2024

Change history

September 30, 2024: Fig. 1 and the article text have been updated to address a production error. Previous version (September 17, 2024)

Acknowledgments

S.U. was supported by grant NIH T32GM136499 (PIs Ruth Stark and Mark Steinberg) and A.H.K. was supported by NIH NS095253 and NIH U54MD017979 (PI Maria Lima).
Author Contributions
S.U. and A.H.K. wrote the paper.
Competing Interests
The authors declare no competing interest.

Notes

See companion article, “Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease”, https://doi.org/10.1073/pnas.2402206121.

Authors

Affiliations

Santiago Uribe-Cano https://orcid.org/0000-0002-3075-6234
City University of New York (CUNY) Graduate Center, Neuroscience Collaborative, New York, NY 10016
Department of Molecular, Cellular and Biomedical Sciences, The City University of New York (CUNY) School of Medicine, New York, NY 10031
View all articles by this author
Andreas H. Kottmann1 https://orcid.org/0000-0002-5435-7502 [email protected]
City University of New York (CUNY) Graduate Center, Neuroscience Collaborative, New York, NY 10016
Department of Molecular, Cellular and Biomedical Sciences, The City University of New York (CUNY) School of Medicine, New York, NY 10031
View all articles by this author

Notes

1
To whom correspondence may be addressed. Email: [email protected].

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The primary cilium of cholinergic neurons may be a linchpin in the progression of Parkinson’s Disease
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