Dynamics of spatial summation in primary visual cortex of alert monkeys

October 12, 1999
96 (21) 12073-12078

Abstract

One of the fundamental tasks of the visual cortex is to integrate input from different parts of the retina, parsing an image into contours and surfaces, and then assembling these features into coherent representations of objects. To examine the role of the primary visual cortex in the integration of visual information, we measured the response properties of neurons under different stimulus conditions. Surprisingly, we found that even the most conventional measures of receptive field (RF) size were not fixed, but could vary depending on stimulus contrast and foreground–background relationships. On average, the length of the excitatory RF was 4-fold greater for a low-contrast stimulus than for a stimulus at high contrast. Embedding a high-contrast stimulus in a textured background tended to suppress neuronal responses and produced an enlargement in RF size similar to that observed by decreasing the contrast of an isolated stimulus. The results show that RF dimensions are regulated in a dynamic manner that depends both on local stimulus characteristics, such as contrast, and on global relationships between a stimulus and its surroundings.

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Acknowledgments

We thank Kaare Christian for software development, Andy Glatz and Joel Lopez for expert technical assistance, and Steven Kane for help with eye coil implantation. Roy Crist, Aniruddha Das, Mariano Sigman, and Torsten Wiesel provided helpful criticisms on earlier versions of the manuscript. The work was supported by National Institutes of Health grants (EY07968 to C.D.G. and MH11394 to M.K.K.).

Supplementary Material

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Information & Authors

Information

Published in

Go to Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Vol. 96 | No. 21
October 12, 1999
PubMed: 10518578

Classifications

Submission history

Received: June 14, 1999
Accepted: August 11, 1999
Published online: October 12, 1999
Published in issue: October 12, 1999

Acknowledgments

We thank Kaare Christian for software development, Andy Glatz and Joel Lopez for expert technical assistance, and Steven Kane for help with eye coil implantation. Roy Crist, Aniruddha Das, Mariano Sigman, and Torsten Wiesel provided helpful criticisms on earlier versions of the manuscript. The work was supported by National Institutes of Health grants (EY07968 to C.D.G. and MH11394 to M.K.K.).

Authors

Affiliations

Mitesh K. Kapadia
The Rockefeller University, New York, NY 10021; and Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
Gerald Westheimer
The Rockefeller University, New York, NY 10021; and Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
Charles D. Gilbert
The Rockefeller University, New York, NY 10021; and Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104

Notes

To whom reprint requests should be addressed at: The Rockefeller University, 1230 York Avenue, New York, NY 10021. E-mail: [email protected].
Communicated by Torsten N. Wiesel, The Rockefeller University, New York, NY

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    Dynamics of spatial summation in primary visual cortex of alert monkeys
    Proceedings of the National Academy of Sciences
    • Vol. 96
    • No. 21
    • pp. 11689-12209

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