Table 1. Functional categories of selected c-Myc/Max target genes
Functional category c-Myc/Max targets
Signal transduction AKAP10, AKAP9, APPL, ARFRP1, ATF6, ATM, CD164, CD2AP, CD79B, CD97, COPS3, CORO1C, CR2, CREB1, CREBL2, CSF2RB, CUL5, DAP3, DAXX, DDXBP1, DPYSL3, FUS1, FZD5, GDAP1, GNA12, GNL1, GPRK2L, HCR, IFNAR1, IFNGR1, IL17C, ILK, ITGB3BP, LANCL1, LNPEP, LOC51657, MADD, MADH3, MAP2K5, MAP2K7, MAP3K5, MAPK7, MAPRE2, MD-1, MKLN1, MKNK1, MST1R, NFAT5, NFKBIB, NR1D1, NR6A1, P85SPR, PDK1, POR1, PREP, PRKAB1, PRKAB2, PRKCL2, PRKRA, PRKRIR, PTPN1, PTPN6, PTPRF, RAC2, RAGA, RAP2B, RGS16, RHEB2, RIPK2, RLN1, RNF7, RPS6KA2, RPS6KA5, RPS6KB1, RRAS, RXRB, SRD5A1, SRP54, SRP68, SRPR, TLE3, TRIP15, ZNF147, and ZNF259
Cell cycle 101F6, APC10, ATM, CCT7, CDC25B, CDC6, CDK6, CDKN1B, CUL5, DNAJA2, FRAP1, GAK, LATS1, LOC51723, MAPRE1, MCM5, MPHOSPH1, MPHOSPH6, P23, PA2G4, PCNA, PCTK1, PPP2CA, PSMD8, RBBP8, RBL1, SGT1, TOPBP1, TP53, and TSC2
Cell growth/proliferation APPL, BARD1, BLZF1, C8FW, CD164, CDC16, CDC25B, CDC6, CDK6, CDKN1B, CIAO1, CKS2, CUL5, DDX1, DNAJA2, ELL, FUS1, GNA12, HKLP2, ING1, LATS1, MAPRE1, MAPRE2, MD-1, MST1R, MT3, NR6A1, P23, PA2G4, PCNA, PRKRA, PRKRIR, SEI1, SKB1, SYK, TSPY, XIP, and ZNF259
Cell death/apoptosis ABS, APG12L, ASC, CRADD, CUL5, DAP3, DAXX, MAEA, MAP3K5, MD-1, PDCD8, PTPN6, RAGA, RIPK2, RNF7, SMAC, and TP53
Transporter ABCB6, AKR7A2, ATP5B, ATP5C1, ATP5G2, CACNB1, CLCN2, CLCN3, CLCN6, COX15, DEGS, H6PD, IDH3B, KCNH4, NUP153, NUP88, PPIA, PRDX5, SLC12A2, SLC1A4, SLC22A3, SLC22A4, SLC25A11, SLC26A4, SLC2A4, SLC31A1, SLC5A6, SLC7A1, SRD5A1, VDAC2, VDAC3, and XK
Cell adhesion CD164, CD97, CNTN2, CORO1C, DGCR6, FLOT2, ILK, ITGB3BP, MAEA, MKLN1, P84, PTPRF, and SIP2-28
DNA replication CDC6, CHRAC17, MCM3, MCM5, PCNA, POLD4, PPIA, RAD9, TOPBP1, and XIP
DNA repair ABH, ADPRTL2, ADPRTL3, ATM, DDB1, ERCC6, EXO1, FRAP1, G22P1, JTV1, MBD4, MSH2, PCNA, PIR51, PMS1, POLH, PRKDC, RAD50, RAD54L, RAD9, RBBP8, RECQL, RECQL5, SIP2-28, and TP53
Protein biosynthesis MARS, NACA, PET112L, PYCR1, RPL13, RPL15, RPL18, RPL19, RPL27A, RPL31, RPL37, RPL5, RPL8, RPL9, RPLP1, RPS13, RPS17, RPS19, RPS20, RPS21, RPS25, RPS26, RPS29, RPS5, RPS6, and SARS
Metabolism ACAD8, ACOX3, AGPS, AKR7A2, ASAH, BCKDHA, BCKDHB, BTN2A1, CARKL, CEPT1, CH25H, CYBA, DPYSL3, EPM2A, GCLC, GMDS, GNPAT, IDH3B, LOC51172, LOC51601, LTA4H, MAT2A, MGAT2, MOCS2, MT3, MTHFD1, NAGA, NIFS, OAZ1, PDK1, PDK2, PDK3, PLA2G4B, PLA2G6, PMVK, PP, PRPS2, PRPSAP1, PYCR1, SCLY, SLC2A4, SLC7A1, SREBF2, SSB, ST6GALNACIV, TOPBP1, and ZNRD1
Oncogenesis/tumor suppressor ABCB6, AKR7A2, ARMET, BARD1, CUL5, DDX1, DLEU1, DLEU2, HMMR, ING1, LATS1, MADH3, MAPRE1, MEL, MSH2, MYBBP1A, PMS1, POV1, PPP2CA, PPP2R1B, PTP4A1, RPS19, TP53, TSC2, TSPY, and TTC4
Proteasome POH1, POH1, PSMA1, PSMA5, PSMB1, PSMB5, PSMB7, PSMC4, PSMC5, PSMD10, PSMD3, PSMD5, PSMD7, PSMD8, and PSME3
Transcription factor/cofactor ABT1, ATF4, ATF6, CALR, CBF2, CGBP, CIR, CREB1, CREBL2, CRSP6, CSDA, DDXBP1, GABPA, HCF-2, IRF3, LOC51042, LZTR1, MADH3, MAFF, MYCBP, NFAT5, NFKBIB, NR1D1, POU2F1, PSMC5, RBBP1, RBBP2, RFX5, RNF4, RXRB, SAP18, SAP30, SCML2, SP4, SUPT5H, TIF1, TMF1, TP53, TRAP150, TRIP13, YY1, ZNF136, ZNF142, ZNF147, ZNF174, ZNF192, ZNF274, ZNF35, and ZNF85