Table 1. Disruption of the PG pathway in CIA
Impact on disease outcome
Manipulation AUC (disease progression) Clinical score (terminal day)
COX-1-/- (32) Not effective Not effective
COX-2-/- (32) Effective Effective
mPGES1-/- Effective Effective
NSAID Effective Effective
COX-2 inhibitor (31) Effective Effective
  • Area under the curve (AUC) and terminal scores were obtained from the published literature [COX-1-/- and COX-2-/- (32); COX-2 inhibitor (SC-046) (31)] and from experiments with the NSAID piroxicam as described above