Table 1. Genes bound by p65 and regulated in response to TNF-α stimulation
Gene symbol Description p65-binding site (relative to ATG)
Up-regulated
    ZBED4* Zinc finger, BED domain 4 +6.4 kb, +28.6 kb, +32.5 kb
    ZNF378 Zinc finger, DHHC domain 1 +3.6 kb
    PIK4CA* Type II phosphatidylinositol 4-kinase -4.5 kb, -325 bp, and 8 internal
    AP000557.3 Similar to human PIK4CA +543 bp, +5.4 kb
    EWSR1* Ewing sarcoma breakpoint region 1 +1740 bp
    SMC1L2 Mitosis-specific chromosome segregation (SMC1)-like 2 -5 kb, +30 kb
    NF2* Neurofibromatosis 2 +61 kb
    ARFGAP3* ADP-ribosylation factor GTPase activating protein 3 -10 kb
    KIAA0542 mRNA for KIAA0542 +25, +32, +41 kb
    AC007050.4* POM121-like 1 +697 bp
    AC005005.6 Homo sapiens cDNA: FLJ23382 +32 kb
Down-regulated
    BSAC/MKL1* Megakaryoblastic leukemia 1 -3 kb, -100 bp, +30 kb MKL1*
    SBF1* SET binding factor 1 +5.5 kb
    dJ756G23.3* Similar to Drosophila Tr:Q24191 transcriptional repressor +10 kb
    RABL2B RAB—RAS family-like 2B +15 kb
    ADTB1 Adaptin beta 1 (beta prime) +4.8 kb
    bA247113.2 Matches EST sequences -18.5 kb, -4 kb
  • * p65 binding confirmed by PCR.

  • First intron of gene.