Table 2. C3b binding activity of MCP derived from lysates of PBMCs
Family Patient ID C3b binding, % WT MCP
1 C Exp. 1: 56/57
Exp. 2: 57/59
2 D 34 ± 4.5
E 40 ± 2.0
3 F 1 ± 0.7
G 1 ± 0.4
  • These data were derived from two experiments for family 1 (each performed in duplicate) and three separate experiments for families 2 and 3 (each performed in triplicate with standard error shown). WT binding (assigned a value of 100%) was derived from a pool of PBMC lysates of normal individuals.