Table 3. Tumor suppressor genes
Linear
N Moran, τ = 1 τ0 = 1 τ0 = 10
100 11127 82 1
1000 23539 82 1
10000 180790 82 1
  • Tumor suppressor genes require inactivation of both alleles for the cell to have an increased net growth rate. Here we show the expected number of mutated compartments at t = 70 years of age in an organ that contains 107 compartments. Parameters are u1 = 10-7, u2 = 10-6, and ρ = 1/2. The linear process leads to a much smaller number of mutated compartments, thereby efficiently delaying cancer initiation.