Table 1

Relative rates of proliferation by CD4 T cells in TCR Tg RAG−/− mice at steady state are similar to naive CD4 T cells in normal mice

Mouse strainNo. of naive CD4 T cells × 10−6 ± SEDaily rate of BrdUrd incorporation, % BrdUrd + cells ± SE
C57BL/641.0 ± 13.11.46 ± 0.39
BALB/c46.0 ± 3.80.94 ± 0.11
DO11.10 RAG-2−/−24.7 ± 1.40.72 ± 0.29
HA RAG-2−/−15.1 ± 3.90.78 ± 0.07
OT-II RAG-1−/−8.9 ± 2.81.40 ± 0.58
SM-1 RAG-2−/−22.4 ± 6.50.97 ± 0.30
  • Average numbers (from six to nine mice) of naive T cells within spleens and lymph nodes in different strains are indicated. CD45RB expression was used to define naive T cells in normal mice. Mice were injected daily with BrdUrd for 7–10 days. The fraction of naive T cells that incorporated BrdUrd was measured by flow cytometry. An average daily rate of BrdUrd incorporation from four individual mice in each group is shown.