Table 1

Sequence similarities of regulatory elements encoded on pE88 to the characterized regulatory proteins UviA of C. perfringens, TxeR of C. difficile, and BotR/A of C. botulinum

ORF name and size*AnnotationUviA (185 aa)TxeR (184 aa)BotR/A (178 aa)
CTP5 (172 aa)Frameshift, UviA homolog32% (48%) >185 aa31% (49%) >170 aa26% (43%) >178 aa
CTP10 (179 aa)Putative σ-factor/DNA-binding protein24% (43%) >184 aa28% (47%) >82 aan.s.
CTP11 (184 aa)Putative σ-factor/DNA-binding protein25% (44%) >180 aa24% (44%) >179 aan.s.
TetR (177 aa)Positive regulator of tetX27% (49%) >183 aa26% (47%) >184 aa67% (85%) >177 aa
  • Percentages indicate identical (in parentheses: similar) amino acids. n.s., not significant. 

  • * Not listed here is the two-component system CTP21/CTP22 and CTP4 (71 aa), which shows homology only to UviB (64 aa) of C. perfringens (40% identity over 67 aa).