Table 1

Enrichment of identified ORFs within functional categories

Functional categories (unique entries in MIPS)Genome (N = 6,352) Wortmannin list (n = 1,067) Enrichment ratio (YORF)P value
ORFs # (M)(M/N) ×100%ORFs # (m)(m/n) ×100%
Lipid metabolism2533.98605.621.40.0025
DNA replication and repair1913.01605.621.93.28 × 10−7
Protein synthesis3595.6511911.152.04.41 × 10−15
Protein degradation1662.61504.691.81.19 × 10−5
Chromatin and general transcription1882.96595.531.94.28 × 10−7
Metabolism1,06616.78777.220.40.9999
Mitochondrial localization3665.7611010.311.86.47 × 10−11
Unknown or unclassified2,60140.9546343.391.10.041
  • Bioinformatic analyses of the wortmannin-sensitive cellular network. A quantitative representation of wortmannin-responsive genes in S. cerevisiae functional categories is shown.