Table 1

Engraftment of human breast cancers into NOD/SCID mice

TumorOriginFormation in micePassage in miceDiagnosis
T1MetastasisYesYesInfiltrating ductal carcinoma
T2Breast primaryYesYesAdenocarcinoma
T3MetastasisYesYesInvasive lobular carcinoma
T4MetastasisYesNoInvasive lobular carcinoma
T5MetastasisYesYesInvasive lobular carcinoma
T6MetastasisYesYesInflammatory breast carcinoma
T7MetastasisYesYesInvasive lobular carcinoma
T8MetastasisYesYesInflammatory breast carcinoma
T9MetastasisYesYesAdenocarcinoma
  • Mice were injected with unsorted T1 and T3 cells and a 2-mm piece of T2. Cells from T4–T9 were isolated by flow cytometry as described in Fig. 1. All nine tumors tested engrafted in our NOD/SCID mouse model. Except for T2, which was a primary breast tumor, all other tumors were metastases. All of the tumors were passaged serially in mice except for T4.