Table 2. Expression of the human γ-gene in transgenic mice carrying a μLCRAγ construct with the human -159γ or the galago -157γ promoter
Human γ, % of murine α-mRNA per copy
Embryonic erythropoiesis
Definitive erythropoiesis
Line Copy no. Day 12 blood Day 12 yolk sac Day 12 fetal liver Adult blood
LCR(-157g)Aγ
    F 7 16.0 ± 0.7 27.6 ± 2.5 7.8 ± 1.1 2.3 ± 0.6
    G 15 1.4 ± 0.1
    H 19 11.0 ± 0.6 25.0 ± 5.1 6.6 ± 0.4 1.3 ± 0.3
    I 4 14.2 ± 6.1 19.5 ± 6.3 10.8 ± 4.2 1.6 ± 0.1
    J 14 14.5 ± 2.2 30.8 ± 6.3 9.9 ± 0.5 1.3 ± 0.3
    K 4 14.5 ± 0.2 23.9 ± 1.9 6.3 ± 0.1 0.7 ± 0.1
Mean 14.0 ± 1.8 25.4 ± 4.2 8.3 ± 2.0 1.4 ± 0.5
μLCR(-159h)Aγ
    L 1 14.4 ± 0.7 36.9 ± 2.7 20.5 ± 0.2 13.4 ± 1.0
    M 53 3.7 ± 0.1 16.5 ± 8.4 9.9 ± 1.1 17.7 ± 3.2
    N 61 5.0 ± 0.9 23.1 ± 5.0 10.5 ± 0.9 10.1 ± 0.8
    O 23 13.1 ± 2.2 30.0 ± 8.4 15.2 ± 3.4 16.1 ± 8.7
Mean 9.0 ± 5.5 26.6 ± 8.8 14.0 ± 4.9 14.3 ± 3.3
  • See Table 1 legend and footnote.