Table 2. MS analysis
Classifications Proteins
Targeting/adhesion Integrins β1, α3, α7, and αV
MFG-E8, lactadherin
Chaperones
hsc70 and hsp84
Membrane fusion Annexins A1, A2, A3, A4, A5, A6, and A11
Arf3, Arf6, and Arf5
Rab5c, Rab7, and Rab10
RabGDI
Rap1A and Rap2B
Cytoskeleton Actin
Cofillin 1
Moesin
Tubulins α1, α2, β5, β3, and α6
Signal transduction 14-3-3 ξ, γ, ε
Gβ1 and Gi2α
Enzymes Enolase 1
GAPDH
Pyruvate kinase
Histones H2B, H2A, and H4
Others Translation elongation factor 1α
lamp2
C3
  • Proteins found from MS/MS analysis that are common to exosomes from different cell types. Classification was made based on the putative role of proteins according to Thery et al. (18). The other proteins that were sequenced and accession numbers for the National Center for Biotechnology Information nr database are available in Table 3.