Table 1. EAE induction by immunization with MOG33–55 peptide in 129Sv PD-L1-deficient mice
Clinical EAE*
Histological EAE
Mice Incidence Mortality Day of onset Mean maximal score Meningeal foci Parenchymal foci Total foci
WT 10/13 (77%) 1/14 (7%) 12 ± 0.6 1.6 ± 0.39 49.8 ± 13.5 29.8 ± 9.0 79.6 ± 21.0
PD-L1-/- 13/14 (92.8%) 7/14 (50%) 10.5 ± 0.4 3.7 ± 0.52 75.8 ± 15.0 65.7 ± 15.0 141.6 ± 26.2
P < 0.001§ P = 0.02§ P = 0.02§
  • * Mice were immunized with MOG33-55 peptide and scored daily for 25 days.

  • Mice were immunized with MOG33-55 peptide and killed at day 11 for histology.

  • Data represent mean ± SE.

  • § P values are compared with wild type (Student's t test).