Table 1. Lineage-specific kinases in mouse and human
Gene Found only in Introns Rat ortholog Other orthologs Closest paralog (%) Notes
Retrotransposed copies
CK1α2 Human No No Chimp CK1α (91) Ka/Ks = 0.0463/0.2656 = 0.0463
TAF1L Human No No Primate TAF1 (92) Ka/Ks = 0.0217/0.0814 = 0.2666
PKACγ Human No No Primate PKACα (83) Ka/Ks = 0.0829/0.4658 = 0.1880
CK2α1-rs Mouse No No No CK2α1 (99) Ka/Ks = 0.0011/0.0037 = 0.2972
A6-rs Mouse No No No A6 (96) Ka/Ks = 0.0150/0.0689 = 0.217
NDR2-rs Mouse No No No NDR2 (97) Ka/Ks = 0.0111/0.0233 = 0.4764
Gene loss
PSKH2 Human Yes No Chimp PSKH1 (≈70)
DRAK1 Human Yes No Dog, rabbit DRAK2 (54)
GPRK7 Human Yes No Squirrel, pig, cow, fishes GPRK4 (47)
CDK3 Human Yes Pseudogene Chimp CDK2 (76) Pseudogene in mouse, rat
KSGC Mouse Yes Yes No ANPa (35) Pseudogene in human
PLK5 Mouse Yes Yes No PLK2 (37) Pseudogene in human
CYGX Mouse Yes Yes No CYGF (51) Pseudogene in human
TSSK5 Mouse Yes Yes No TSSK2 (36) Pseudogene in human
Other
PRKY Human Yes No No PRKX (92) Mouse Chr Y not yet sequenced
MARKs Mouse Some Some No Varied Twenty-five genes; fast evolving