Table 2. The amount of mRNA in the kidney of the four groups of animals
Genotype Bdkrb2+/+Ins2+/+Bdkrb2−/−Ins2+/+Bdkrb2+/+Ins2+/C96YBdkrb2−/−Ins2+/C96Y
B2 receptor 32.8 ± 4.3 (100 ± 13) 0.0 ± 0.0* (0 ± 0) 67.7 ± 12.7* (207 ± 39) 0.0 ± 0.0* , (0 ± 0)
B1 receptor 3.1 ± 0.4 (100 ± 13) 35.2 ± 3.4* (1,132 ± 109) 37.1 ± 2.1* (1,196 ± 67) 78.0 ± 8.0* , (2,511 ± 257)
Megsin 0.257 ± 0.034 (100 ± 13) 0.306 ± 0.040 (119 ± 16) 0.462 ± 0.049* (180 ± 19) 0.831 ± 0.105* , (323 ± 41)
Nephrin 1.44 ± 0.19 (100 ± 13) 1.61 ± 0.16 (112 ± 11) 3.03 ± 0.39* (210 ± 27) 4.47 ± 0.28* , (310 ± 19)
  • Data are given as pg mRNA of genes of interest in μg total RNA (mean ± SEM). Relative expression levels (% wild type) are shown in parentheses.

  • * P < 0.05 vs. wild type.

  • P < 0.05 vs. Bdkrb2 +/+ Ins2 +/C96Y.